Molecular targets and pathways for the treatment of visceral leishmaniasis.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Drug Discovery Today

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.drudis.2017.09.006PMID 28919438
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Leishmania donovani

  2020cited by this paper
• Safety and efficacy of short course combination regimens with AmBisome, miltefosine and paromomycin for the treatment of visceral leishmaniasis (VL) in Bangladesh

  2017cited by this paper
• The expression of NTPDase1 and -2 of Leishmania infantum chagasi in bacterial and mammalian cells: Comparative expression, refolding and nucleotidase characterization.

  2017influential reference
• Structure-based virtual screening, molecular docking, ADMET and molecular simulations to develop benzoxaborole analogs as potential inhibitor against Leishmania donovani trypanothione reductase

  2017cited by this paper
• Novel &bgr;‐carboline‐quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity

  2017cited by this paper
• Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice

  2017cited by this paper
• Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches

  2017cited by this paper
• Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation

  2017cited by this paper
• Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.

  2017cited by this paper
• Between-Country Inequalities in the Neglected Tropical Disease Burden in 1990 and 2010, with Projections for 2020

  2016cited by this paper
• Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

  2016influential reference
• Differential protein abundance in promastigotes of nitric oxide‐sensitive and resistant Leishmania chagasi strains

  2016cited by this paper
• Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes

  2016cited by this paper
• A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani

  2016cited by this paper
• Biomedical Applications of Carbon Nanotubes: A Critical Review.

  2016cited by this paper
• Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts

  2016cited by this paper
• A GCN2-Like eIF2α Kinase (LdeK1) of Leishmania donovani and Its Possible Role in Stress Response

  2016cited by this paper
• Plumbagin, a plant-derived naphthoquinone metabolite induces mitochondria mediated apoptosis-like cell death in Leishmania donovani: an ultrastructural and physiological study

  2016cited by this paper
• Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

  2016cited by this paper
• Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

  2016influential reference
• Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway

  2016cited by this paper
• Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase.

  2016cited by this paper
• Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

  2016cited by this paper
• Molecular Modeling and Virtual Screening Approach to Discover Potential Antileishmanial Inhibitors Against Ornithine Decarboxylase.

  2016influential reference
• Molecular Dynamics Simulation and Docking Studies of Selenocyanate Derivatives as Anti-Leishmanial Agents.

  2016cited by this paper
• Current Therapeutics, Their Problems and Thiol Metabolism as Potential Drug Targets in Leishmaniasis.

  2016cited by this paper
• Short-Course Treatment Regimen of Indian Visceral Leishmaniasis with an Indian Liposomal Amphotericin B Preparation (Fungisome™).

  2016cited by this paper
• Phosphorylation of Translation Initiation Factor 2-Alpha in Leishmania donovani under Stress Is Necessary for Parasite Survival

  2016cited by this paper
• A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani

  2016influential reference
• Protective inflammatory response against visceral leishmaniasis with potato tuber extract: A new approach of successful therapy.

  2016cited by this paper
• randomized trial to evaluate the efficacy of the eish-Tec ® vaccine against canine visceral leishmaniasis in an ndemic area of Brazil

  2016cited by this paper
• One-Pot Synthesis and Evaluation of Antileishmanial Activities of Functionalized S-Alkyl/Aryl Benzothiazole-2-carbothioate Scaffold.

  2016cited by this paper
• Novel Inhibitors of Ornithine Decarboxylase of Leishmania Parasite (LdODC): The Parasite Resists LdODC Inhibition by Overexpression of Spermidine Synthase

  2016cited by this paper
• Thiol redox biology of trypanosomatids and potential targets for chemotherapy.

  2016cited by this paper
• Leishmania donovani Aurora kinase: A promising therapeutic target against visceral leishmaniasis.

  2016cited by this paper
• GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites.

  2016cited by this paper
• Cross-resistance of Leishmania infantum isolates to nitric oxide from patients refractory to antimony treatment, and greater tolerance to antileishmanial responses by macrophages

  2016cited by this paper
• MAPK1 of Leishmania donovani Modulates Antimony Susceptibility by Downregulating P-Glycoprotein Efflux Pumps

  2015cited by this paper
• Leishmania donovani: impairment of the cellular immune response against recombinant ornithine decarboxylase protein as a possible evasion strategy of Leishmania in visceral leishmaniasis.

  2015cited by this paper
• Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G0/G1 Arrest followed by Necrotic Cell Death in Leishmania donovani

  2015cited by this paper
• Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase.

  2015cited by this paper
• Pharmaceutical and biomedical applications of quantum dots

  2015cited by this paper
• Surface-Engineered Dendrimeric Nanoconjugates for Macrophage-Targeted Delivery of Amphotericin B: Formulation Development and In Vitro and In Vivo Evaluation

  2015cited by this paper
• Cytotoxic Screening and In Vitro Evaluation of Pentadecane Against Leishmania infantum Promastigotes and Amastigotes

  2015cited by this paper
• Developing imidazole analogues as potential inhibitor for Leishmania donovani trypanothione reductase: virtual screening, molecular docking, dynamics and ADMET approach

  2015cited by this paper
• Vaccines for visceral leishmaniasis: A review.

  2015cited by this paper
• The Leishmania donovani peroxin 14 binding domain accommodates a high degeneracy in the pentapeptide motifs present on peroxin 5.

  2015cited by this paper
• Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis

  2015cited by this paper
• New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

  2015cited by this paper
• HAT3-mediated acetylation of PCNA precedes PCNA monoubiquitination following exposure to UV radiation in Leishmania donovani

  2015cited by this paper
• Metabolic reconfiguration of the central glucose metabolism: a crucial strategy of Leishmania donovani for its survival during oxidative stress

  2015cited by this paper
• Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers.

  2015cited by this paper
• An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

  2014cited by this paper
• Chitosan-Assisted Immunotherapy for Intervention of Experimental Leishmaniasis via Amphotericin B-Loaded Solid Lipid Nanoparticles

  2014cited by this paper
• Deletion of Vitamin C biosynthesis enzyme, Arabino‐1, 4‐lactone oxidase in Leishmania donovani results in increased pro‐inflammatory responses from host immune cells

  2014cited by this paper
• Drug resistance analysis by next generation sequencing in Leishmania

  2014cited by this paper
• Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

  2014cited by this paper
• Leishmanicidal activity of Cecropia pachystachya flavonoids: arginase inhibition and altered mitochondrial DNA arrangement.

  2013cited by this paper
• Novel therapeutic strategies for treatment of visceral leishmaniasis.

  2013cited by this paper
• A leishmaniasis study: structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase.

  2012cited by this paper
• The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

  2012cited by this paper
• The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase.

  2012cited by this paper
• Low-Molecular-Mass Antioxidants in Parasites

  2012cited by this paper
• IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice.

  2011cited by this paper
• Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice.

  2011cited by this paper

• A comprehensive review of targeting sterol 14α-demethylase and sterol C-24 methyl transferase, two pivotal proteins in Leishmania, as compelling therapeutic targets.

  2025cites this paper
• Desenvolvimento de um agente anti-infeccioso com lausona para o tratamento da Tuberculose e Leishmaniose

  2025cites this paper
• Design, Hemisynthesis, Characterization, Molecular Docking, and Dynamics Evaluation of Novel Totarol‐1,2,3‐Triazole Derivatives as Leishmaniasis and Toxoplasmosis Agents

  2025cites this paper
• In vitro evaluation against Leishmania amazonensis and Leishmania chagasi of medicinal plant species of interest to the Unified Health System.

  2024cites this paper
• Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products: potential pH-dependent inhibition explored through computer-aided drug design

  2024cites this paper
• Antileishmanial activity of essential oil from a high-altitude herb, Heracleum pinnatum: an in vitro and in silico analysis

  2024cites this paper
• Conjugates of amphotericin B to resolve challenges associated with its delivery

  2024cites this paper
• Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products: pH-dependent inhibition explored through computer-aided drug design

  2024cites this paper
• Averrhoa carambola Leaf Extract Induces Apoptosis-Like Death with Increased ROS Generation in Leishmania donovani

  2024cites this paper
• Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

  2024cites this paper
• Leishmanicidal Activity of Guanidine Derivatives against Leishmania infantum

  2023cites this paper
• One Platform Comparison of Polymeric and Lipidic Nanoparticles for the Delivery of Amphotericin B

  2023cites this paper
• Synergistic combination of Cinnamomum verum and Syzygium aromaticum treatment for cutaneous leishmaniasis and investigation of their molecular mechanism of action

  2023cites this paper
• Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery

  2023cites this paper
• Biological activity and structure–activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis

  2023cites this paper
• Roles of ADP-Ribosylation during Infection Establishment by Trypanosomatidae Parasites

  2023cites this paper
• Emerging strategies and challenges of molecular therapeutics in antileishmanial drug development.

  2023cites this paper
• Leishmania spp. in indigenous populations: A mini-review

  2022cites this paper
• Receptor-Targeted Surface-Engineered Nanomaterials for Breast Cancer Imaging and Theranostic Applications.

  2022cites this paper
• Emerging trends and promises of nanoemulsions in therapeutics of infectious diseases.

  2022cites this paper
• Major Molecular Factors Related to Leishmania Pathogenicity

  2022cites this paper
• Emerging concerns of infectious diseases and drug delivery challenges

  2022cites this paper
• Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response

  2022cites this paper
• Chemical Composition and In Vitro and In Silico Antileishmanial Evaluation of the Essential Oil from Croton linearis Jacq. Stems

  2022cites this paper
• Leishmanicidal and cytotoxic activity of essential oil from the fruit peel of Myrciaria floribunda (H. West ex Willd.) O. Berg: Molecular docking and molecular dynamics simulations of its major constituent onto Leishmania enzyme targets

  2021cites this paper
• Antileishmanial Drug Discovery and Development: Time to Reset the Model?

  2021cites this paper
• Classical and Modern Drug Treatments for Leishmaniasis

  2021cites this paper
• Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

  2021cites this paper
• Decreased glutamate transport in acivicin resistant Leishmania tarentolae

  2021cites this paper
• An overview of the fatty acid biosynthesis in the protozoan parasite Leishmania and its relevance as a drug target against leishmaniasis.

  2021cites this paper
• New diarylsulfonamide inhibitors of Leishmania infantum amastigotes

  2021cites this paper
• Efficient Dimerization Disruption of Leishmania infantum Trypanothione Reductase by Triazole-phenyl-thiazoles

  2021cites this paper
• Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis

  2021cites this paper
• Antileishmanial and cytotoxic activity of secondary metabolites from Taberneamontana ventricosa and two aloe species

  2021cites this paper
• Outwitting an old neglected nemesis: A review on leveraging integrated data-driven approaches to aid in unraveling of leishmanicides of therapeutic potential.

  2020cites this paper
• Antileishmanial activity of amphiphilic chlorin derivatives mediated by photodynamic therapy.

  2020cites this paper
• Targeting the Trypanothione Reductase of Tissue-Residing Leishmania in Hosts' Reticuloendothelial System: A Flexible Water-Soluble Ferrocenylquinoline-Based Preclinical Drug Candidate.

  2020cites this paper
• In vitro and in silico analysis of L. donovani enoyl acyl carrier protein reductase - A possible drug target

  2020cites this paper
• Molecular modeling and simulation study of homoserine kinase as an effective leishmanial drug target

  2020cites this paper
• Exploring Endoperoxides as Leishmanicidal Compounds

  2019cites this paper
• Envisioning the innovations in nanomedicine to combat visceral leishmaniasis: for future theranostic application.

  2019cites this paper
• GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis

  2019cites this paper
• Design and synthesis of imidazolidinone derivatives as potent anti‐leishmanial agents by bioisosterism

  2019cites this paper
• Validation of NAD synthase inhibitors for inhibiting the cell viability of Leishmania donovani: In silico and in vitro approach

  2019cites this paper
• Efectividad in vivo de una nanoemulsión de paramomicina y ftalocianina de aluminio clorada para el tratamiento de leishmaniasis cutánea

  2019cites this paper
• Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

  2019cites this paper