Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II

A few neurotransmitter systems have fascinated the research community, as muchas the opioid system (i.e., opioid ligands and their receptors) [...].

• Publication year

  2022

• Venue

  Molecules

• Publication date

  2022-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3390/molecules27103140PMID 35630616PMCID 9143373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain

  2022cited by this paper
• Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation

  2022cited by this paper
• Correction: Tanguturi et al. Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists. Molecules 2021, 26, 6693

  2022cited by this paper
• Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors

  2022cited by this paper
• An updated assessment of the translational promise of G-protein-biased kappa opioid receptor agonists to treat pain and other indications without debilitating adverse effects.

  2022cited by this paper
• Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists.

  2021cited by this paper
• Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain

  2021cited by this paper
• Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity

  2021cited by this paper
• Profiling the Effects of Repetitive Morphine Administration on Motor Behavior in Rats

  2021cited by this paper
• SR-17018 Stimulates Atypical µ-Opioid Receptor Phosphorylation and Dephosphorylation

  2021cited by this paper
• Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development.

  2021cited by this paper
• Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic

  2021cited by this paper
• In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

  2021cited by this paper
• Difelikefalin: First Approval

  2021cited by this paper
• Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain

  2021cited by this paper
• Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists

  2021cited by this paper
• Characterization of the Synergistic Effect between Ligands of Opioid and Free Fatty Acid Receptors in the Mouse Model of Colitis

  2021cited by this paper
• Identification of a Novel Delta Opioid Receptor Agonist Chemotype with Potential Negative Allosteric Modulator Capabilities

  2021cited by this paper
• Synthesis, Pharmacological Evaluation, and Computational Studies of Cyclic Opioid Peptidomimetics Containing β3-Lysine

  2021cited by this paper
• Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

  2020cited by this paper
• Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

  2020cited by this paper
• The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics

  2020cited by this paper
• Molecular Genetics of Kappa Opioids in Pain and Itch Sensations.

  2020cited by this paper
• Effect of captopril, an angiotensin-converting enzyme inhibitor, on morphine analgesia and tolerance in rats, and elucidating the inflammation and endoplasmic reticulum stress pathway in this effect.

  2020cited by this paper
• Development of Novel δ Opioid Receptor Inverse Agonists without a Basic Nitrogen Atom and Their Antitussive Effects in Mice.

  2019cited by this paper
• Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides.

  2019cited by this paper
• Novel drugs for the treatment of chronic pruritus

  2018cited by this paper
• Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives

  2018cited by this paper
• Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.

  2017cited by this paper
• Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

  2016cited by this paper
• Nalfurafine hydrochloride to treat pruritus: a review

  2015cited by this paper
• Novel Screening Assay for the Selective Detection of G-Protein-Coupled Receptor Heteromer Signaling

  2013cited by this paper
• Synthesis and biological evaluation of cyclic endomorphin-2 analogs

  2010cited by this paper
• Angiotensin AT(2) receptor agonists act as anti-opioids via EP(3) receptor in mice.

  2009cited by this paper

• No citing papers are available for this paper.