Old yellow enzyme of a novel fungi‐specific class

Old yellow enzymes (OYEs) are flavoproteins that catalyze stereoselective reduction of a wide variety of small molecules including xenobiotic toxins, and are considered as synthetic tools in industrial and pharmaceutical applications. Despite their broad specificity, differences in the enzyme structures influence the yield and stereochemistry of the products. Singh et al. present the three‐dimensional structure and biochemical properties of an OYE of a necrotrophic fungus, Ascochyta rabiei, which belongs to a recently identified fungi‐specific class. Observations of distinct structural features and arrangements of the catalytic‐site residues should contribute to understanding the catalytic mechanism of OYEs of this class.

• Publication year

  2022

• Venue

  The FEBS Journal

• Publication date

  2022-05-19

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/febs.16526PMID 35587530
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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