Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Pharmacological Sciences

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1254/JPHS.94.240PMID 15037808
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine

  2005cited by this paper
• Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.

  2002cited by this paper
• L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective mu opioid agonist, but not to selective delta and kappa agonist at the level of the spinal cord in mice.

  2001cited by this paper
• Screening of Multidrug-Resistance Sensitive Drugs by In Situ Brain Perfusion in P-Glycoprotein-Deficient Mice

  2001cited by this paper
• L‐type and T‐type calcium channel blockade potentiate the analgesic effects of morphine and selective &mgr; opioid agonist, but not to selective &dgr; and &kgr; agonist at the level of the spinal cord in mice

  2001cited by this paper
• Morphine Antinociception Is Enhanced in mdr1a Gene-Deficient Mice

  2000cited by this paper
• Enzyme kinetics and inhibition of nimodipine metabolism in human liver microsomes.

  2000cited by this paper
• Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

  1999cited by this paper
• In vitro and in vivo drug interactions involving human CYP3A.

  1998cited by this paper
• Lack of tolerance in peripheral opioid analgesia in mice.

  1998cited by this paper
• Opioid receptors on peripheral sensory axons.

  1997cited by this paper
• Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels.

  1996cited by this paper
• Enhanced inhibition of microsomal cytochrome P450 3A2 in rat liver during diltiazem biotransformation.

  1996cited by this paper
• Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance.

  1996cited by this paper
• Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity.

  1996cited by this paper
• Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.

  1995cited by this paper
• Evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in rats with peripheral mononeuropathy.

  1995cited by this paper
• The control of pain in peripheral tissue by opioids.

  1995cited by this paper
• In situ hybridization study of μ- and κ-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia

  1994cited by this paper
• In situ hybridization study of mu- and kappa-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia.

  1994cited by this paper
• Reversal effects of several Ca(2+)-entry blockers, neuroleptics and local anaesthetics on P-glycoprotein-mediated vincristine resistance of L1210/VCR mouse leukaemic cell line.

  1994cited by this paper
• Different biotransformation of morphine in isolated liver cells from guinea pig and rat.

  1993cited by this paper
• Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells.

  1993cited by this paper
• Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue.

  1993cited by this paper
• Potentiation of Antinociceptive Effects of Morphine by Calcium‐channel Blockers at the Level of the Spinal Cord

  1993cited by this paper
• Role of opioids in peripheral analgesia.

  1992cited by this paper
• Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation

  1992cited by this paper
• Species difference of site-selective glucuronidation of morphine.

  1991cited by this paper
• Analgesic effects of diltiazem and verapamil after central and peripheral administration in the hot-plate test.

  1990cited by this paper
• Effect of nimodipine on cerebral blood flow and metabolism in rats during hyperventilation.

  1989cited by this paper
• Time Course of Verapamil Interaction with Morphine Effects on Physiological Parameters in Rats

  1989cited by this paper
• Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

  1989cited by this paper
• Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance.

  1988cited by this paper
• Opioid Analgesia at Peripheral Sites: A Target for Opioids Released during Stress and Inflammation?

  1987cited by this paper
• Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists.

  1984cited by this paper
• Effects of diltiazem on renovascular-hypertensive and on normotensive rats.

  1982cited by this paper
• A modification of Haffner's method for testing analgesics.

  1966cited by this paper

• Biased Opioid Receptor Agonists: Balancing Analgesic Efficacy and Side-Effect Profiles

  2025cites this paper
• Evaluating the efficacy and safety of calcium channel blockers as adjunctive analgesics to opioid therapy: a literature review

  2022cites this paper
• Essential role of P-glycoprotein in the mechanism of action of oliceridine

  2022cites this paper
• L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence

  2021cites this paper
• Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision

  2019cites this paper
• Opioid analgesia: modulation by drug interactions and glial activation

  2017cites this paper
• Voltage-Gated Calcium Channel Antagonists: Potential Analgesics for Jejunal Pains

  2017cites this paper
• Verapamil - L type voltage gated calcium channel inhibitor diminishes aggressive behavior in male Siamese fighting fish.

  2015cites this paper
• Withania somnifera root extract prolongs analgesia and suppresses hyperalgesia in mice treated with morphine.

  2014cites this paper
• Role of opioid system in verapamil-induced antinociception in a rat model of orofacial pain

  2014cites this paper
• Anticonvulsant effects of bis-1,4-dihydropyridines and the probable role of L-type calcium channels suggested by docking simulations

  2014influential citation
• In vivo study of ethanol-activated brain protein kinase A: manipulations of Ca2+ distribution and flux.

  2014cites this paper
• ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice

  2014cites this paper
• Blockades of ATP-sensitive potassium channels and L-type calcium channels improve analgesic effect of morphine in alloxan-induced diabetic mice.

  2012cites this paper
• Etoposide modulates the effects of oral morphine analgesia by targeting the intestinal P‐glycoprotein

  2012cites this paper
• Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model.

  2011cites this paper
• Influence of centrally administered diltiazem on behavioural responses, clinical symptoms, reticulo-ruminal contractions and plasma catecholamine level after experimentally induced duodenal distension in sheep.

  2011cites this paper
• Dose-dependent opposite effects of gabapentin on the depressive action of morphine on a C-fibre reflex in the rat.

  2011cites this paper
• Participation of L-type calcium channels in ethanol-induced behavioral stimulation and motor incoordination: effects of diltiazem and verapamil.

  2010cites this paper
• The inhibition of experimentally induced visceral hyperalgesia by nifedipine - a voltage-gated Ca(2+) channels blocker (VGCCs) in sheep.

  2009cites this paper
• Centrally administered verapamil prevents the autonomic reaction to visceral pain in sheep.

  2009cites this paper
• Nimodipine is more effective than nifedipine in attenuating morphine tolerance on chronic co-administration in the rat tail-flick test.

  2008cites this paper
• Involvement of hypothalamic pituitary adrenal axis on the analgesic cross-tolerance between morphine and nifedipine.

  2007cites this paper
• Nifedipine suppresses morphine-induced thermal hyperalgesia: evidence for the role of corticosterone.

  2007cites this paper
• Intrathecal co-administration of morphine and nimodipine produces higher antinociceptive effect by synergistic interaction as evident by injecting different doses of each drug in rats.

  2007cites this paper
• Influence of nifedypine on the hyperalgesic action of duodenal distention in sheep.

  2007cites this paper
• P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice.

  2006cites this paper
• Widespread Neonatal Brain Damage following Calcium Channel Blockade

  2006cites this paper
• UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS BIOLÓGICAS CURSO DE PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS EFEITO ANTINOCICEPTIVO DA DOTARIZINA E FLUNARIZINA EM CAMUNDONGOS

  2005cites this paper
• Nifedipine potentiates antinociceptive effects of morphine in rats by decreasing hypothalamic pituitary adrenal axis activity.

  2005cites this paper
• Enhanced analgesic effect of morphine-nimodipine combination after intraspinal administration as compared to systemic administration in mice

  2005cites this paper
• Endogenous opiates and behavior: 2004.

  2005cites this paper
• Involvement of peripheral mechanism in the verapamil-induced potentiation of morphine analgesia in mice.

  2004cites this paper