Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Epilepsia

• Publication date

  2014-12-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1111/epi.12840PMID 25377760
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic Drift

  2019cited by this paper
• Synchrotron X-ray interlaced microbeams suppress paroxysmal oscillations in neuronal networks initiating generalized epilepsy.

  2013cited by this paper
• T-type calcium channels in burst-firing, network synchrony, and epilepsy.

  2013cited by this paper
• Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

  2013cited by this paper
• Rhythmic neuronal activity in S2 somatosensory and insular cortices contribute to the initiation of absence‐related spike‐and‐wave discharges

  2012cited by this paper
• Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model

  2012cited by this paper
• Early Life Stress Enhancement of Limbic Epileptogenesis in Adult Rats: Mechanistic Insights

  2011cited by this paper
• Genetic drift.

  2011cited by this paper
• Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

  2010cited by this paper
• Anxiolytic effects of rapid amygdala kindling, and the influence of early life experience in rats.

  2009cited by this paper
• Inactivation of the somatosensory cortex prevents paroxysmal oscillations in cortical and related thalamic neurons in a genetic model of absence epilepsy.

  2009cited by this paper
• Morphometric abnormalities and hyperanxiety in genetically epileptic rats: A model of psychiatric comorbidity?

  2009cited by this paper
• A Cav3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy

  2009cited by this paper
• The relationship between age-related development of spike-and-wave discharges and the resistance to amygdaloid kindling in rats with genetic absence epilepsy.

  2008cited by this paper
• Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation.

  2008cited by this paper
• Identifying Neural Drivers with Functional MRI: An Electrophysiological Validation

  2008cited by this paper
• Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants

  2007cited by this paper
• Deep Layer Somatosensory Cortical Neurons Initiate Spike-and-Wave Discharges in a Genetic Model of Absence Seizures

  2007cited by this paper
• Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life

  2006cited by this paper
• New variants in the CACNA1H gene identified in childhood absence epilepsy.

  2006cited by this paper
• Effect of neonatal isolation on outcome following neonatal seizures in rats--the role of corticosterone.

  2006cited by this paper
• Morphometric Golgi study of cortical locations in WAG/Rij rats: the cortical focus theory.

  2005cited by this paper
• Polygenic Control of Idiopathic Generalized Epilepsy Phenotypes in the Genetic Absence Rats from Strasbourg (GAERS)

  2004cited by this paper
• Association between genetic variation of CACNA1H and childhood absence epilepsy

  2003cited by this paper
• Low-Threshold Calcium Currents in Central Nervous System Neurons

  2003cited by this paper
• Suppression of absence seizures by electrical and pharmacological activation of the caudal superior colliculus in a genetic model of absence epilepsy in the rat.

  2002cited by this paper
• Behavioural analysis of four mouse strains in an anxiety test battery.

  2000cited by this paper
• Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP.

  2000cited by this paper
• Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP

  2000cited by this paper
• Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

  1999cited by this paper
• Genetics of mouse behavior: interactions with laboratory environment.

  1999cited by this paper
• Pathophysiological mechanisms of genetic absence epilepsy in the rat.

  1998cited by this paper
• Spurious Associations in Unreplicated Selected Lines

  1997cited by this paper
• Low-threshold calcium currents in central nervous system neurons.

  1996cited by this paper
• Genetic Absence Epilepsy in Rats from Strasbourg (GAERS)

  1995cited by this paper
• Genetic absence epilepsy in rats from Strasbourg--a review.

  1992cited by this paper
• Are rats with genetic absence epilepsy behaviorally impaired?

  1991cited by this paper
• Ontogeny of spontaneous petit mal-like seizures in Wistar rats.

  1986cited by this paper
• Ontogeny of spontaneous petit mal-like seizures in Wistar rats

  1986cited by this paper
• Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy.

  1982cited by this paper

• Rodent models of genetic epilepsy and its association with neurocognitive impairment- a systematic review

  2026cites this paper
• Classifying seizure generation mechanisms: A critical transitions framework

  2025cites this paper
• Impairment of Spatial Working Memory but Preservation of Recognition Memory in Female Rats with Spontaneous Absence Seizures

  2025cites this paper
• Effects of valproate on the entry of inert hydrophilic markers and expression of tight junction associated genes in the neonatal brain and choroid plexus of a rat model of epilepsy (GAERS)

  2025cites this paper
• Evaluation of isolated and combined effects of riluzole and sodium valproate in genetic absence epilepsy rats

  2025cites this paper
• The Influence of Climatic Factors on the Provocation of Epileptic Seizures

  2024influential citation
• Spectral and coupling characteristics of somatosensory cortex and centromedian thalamus differentiate between pre- and interictal 5-9 Hz oscillations in a genetic rat model of absence epilepsy.

  2024cites this paper
• MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy

  2023cites this paper
• A quantitative and T‐pattern analysis of anxiety‐like behavior in male GAERS, NEC, and Wistar rats bred under the same conditions, against a commercially available Wistar control group in the hole board and elevated plus maze tests

  2023cites this paper
• Cognitive comorbidities of experimental absence seizures are independent of anxiety.

  2023cites this paper
• Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models.

  2023cites this paper
• Metyrapone abolishes spike–wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones

  2023cites this paper
• Inherited pain hypersensitivity and increased anxiety-like behaviors are associated with genetic epilepsy in Wistar Audiogenic Rats: Short- and long-term effects of acute and chronic seizures on nociception and anxiety.

  2023cites this paper
• Increased TRPV1 Channels and FosB Protein Expression Are Associated with Chronic Epileptic Seizures and Anxiogenic-like Behaviors in a Preclinical Model of Temporal Lobe Epilepsy

  2022cites this paper
• The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities

  2022cites this paper
• Genetic models to investigate chronic epileptogenic events: An open window of possibilities and perspectives.

  2022cites this paper
• An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy

  2022cites this paper
• Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in Genetic Absence Epilepsy Rats From Strasbourg and Non-epileptic Control Rats

  2022cites this paper
• Neuroplastic alterations in cannabinoid receptors type 1 (CB1) in animal models of epileptic seizures.

  2022cites this paper
• Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in GAERS and NEC rats

  2022cites this paper
• The Effects of Optogenetic Activation of Astrocytes on Spike-and-Wave Discharges in Genetic Absence Epileptic Rats

  2022cites this paper
• The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

  2022cites this paper
• Disease Modification in Epilepsy: Behavioural Accompaniments.

  2021cites this paper
• Seizure Prediction in Genetic Rat Models of Absence Epilepsy: Improved Performance through Multiple-Site Cortico-Thalamic Recordings Combined with Machine Learning

  2021cites this paper
• Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions

  2021cites this paper
• Absence epilepsy in male and female WAG/Rij rats: A longitudinal EEG analysis of seizure expression.

  2021cites this paper
• Retrosplenial Cortex Contributes to Network Changes during Seizures in the GAERS Absence Epilepsy Rat Model

  2021cites this paper
• Climate change and epilepsy: Insights from clinical and basic science studies

  2021cites this paper
• Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

  2020cites this paper
• Cognitive impairments in touchscreen-based visual discrimination and reversal learning in Genetic Absence Epilepsy Rats from Strasbourg.

  2020cites this paper
• Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

  2020cites this paper
• A rat model of valproate teratogenicity from chronic oral treatment during pregnancy

  2020cites this paper
• Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

  2020cites this paper
• СУЧАСНІ ПРИНЦИПИ ТА ТЕХНІЧНЕ ЗАБЕЗПЕЧЕННЯ ДОСЛІДЖЕНЬ НА МОДЕЛІ ГЕНЕТИЧНОЇ ФОРМИ АБСАНСНОЇ ЕПІЛЕПСІЇ

  2020cites this paper
• Glutamate transmission rather than cellular pacemaking propels excitatory-inhibitory resonance for ictogenesis in amygdala.

  2020cites this paper
• Dual role of T-type calcium channels in anxiety-related behavior

  2019cites this paper
• Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis

  2019cites this paper
• Cortical activation in generalized seizures

  2019cites this paper
• The T‐type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg

  2019cites this paper
• Imaging Neural Excitability and Networks in Genetic Absence Epilepsy Models

  2019influential citation
• The T‐type calcium channel blocker Z944 reduces conditioned fear in Genetic Absence Epilepsy Rats from Strasbourg and the non‐epileptic control strain

  2019cites this paper
• Opening of T-type Ca2+ channels and activation of HCN channels contribute in stress adaptation in cold water immersion stress-subjected mice.

  2019cites this paper
• Cav3.2 T‐type calcium channel mutation influences kindling‐induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

  2019cites this paper
• Neonatal whisker trimming in WAG/Rij rat pups causes developmental delay, encourages maternal care and affects exploratory activity in adulthood.

  2018cites this paper
• Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model

  2018influential citation
• Genetically Epilepsy-Prone Rats Display Anxiety-Like Behaviors and Neuropsychiatric Comorbidities of Epilepsy

  2018cites this paper
• Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes

  2018cites this paper
• Exploiting Novelty and Oddity Exploratory Preferences in Rodents to Study Multisensory Object Memory and Perception

  2018cites this paper
• A review on the animal models of seizure: review article

  2018cites this paper
• Disease-Modifying Effects of Neural Regeneration Peptide 2945 in the GAERS Model of Absence Epilepsy

  2017cites this paper
• Sociability impairments in Genetic Absence Epilepsy Rats from Strasbourg: Reversal by the T‐type calcium channel antagonist Z944

  2017influential citation
• Evaluating whole genome sequence data from the Genetic Absence Epilepsy Rat from Strasbourg and its related non-epileptic strain

  2017cites this paper
• Genetic Models of Absence Epilepsy in Rats and Mice

  2017cites this paper
• Pathophysiology of absence epilepsy: Insights from genetic models.

  2017cites this paper
• Sleep spindles in rats with absence epilepsy

  2017cites this paper
• The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: History and perspectives.

  2017cites this paper
• Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels

  2017cites this paper
• The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.

  2016cites this paper
• The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg.

  2016cites this paper
• Neurobehavioral Comorbidities of Epilepsy: Lessons from Animal Models

  2016cites this paper
• Contrôle des activités synchrones oscillatoires pathologiques par le récepteur dopaminergique D3 et le transporteur de la dopamine.

  2016cites this paper
• The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies.

  2016cites this paper
• Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines

  2016cites this paper
• 2014 Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment across the Lifespan

  2016cites this paper
• The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans

  2016influential citation
• Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety.

  2016cites this paper
• Assessing Susceptibility to Epilepsy in Three Rat Strains Using Brain Metabolic Profiling Based on HRMAS NMR Spectroscopy and Chemometrics.

  2015cites this paper
• Inadequate experimental methods and erroneous epilepsy diagnostic criteria result in confounding acquired focal epilepsy with genetic absence epilepsy

  2015cites this paper
• Olfactory Bulbectomy Leads to the Development of Epilepsy in Mice

  2015cites this paper
• Progress in research on animal models of epilepsy-associated depression

  year unknowncites this paper