Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Virology

• Publication date

  1999-01-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/VIRO.1998.9500PMID 9918874
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
• HTLV‐1 Tax protein interacts with cyclin‐dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

  1996cited by this paper
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  1996cited by this paper
• Repression of the NF1 gene by Tax may expain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice

  1996cited by this paper
• Molecular analysis of lacI mutations in Rat2 cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation.

  1996cited by this paper
• Spontaneous and ethylnitrosourea-induced mutation fixation and molecular spectra at the lacI transgene in the Big Blue rat-2 embryo cell line.

  1996cited by this paper
• Development of a rat cell line containing stably integrated copies of a lambda/lacI shuttle vector.

  1995cited by this paper
• Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU‐treated big blue™ B6C3F1 mice

  1995cited by this paper
• Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions.

  1995cited by this paper
• A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

  1993cited by this paper
• Induction of micronuclei by HTLV-I Tax: a cellular assay for function.

  1993cited by this paper
• HTLV-1 Tax: regulation of gene expression and disease.

  1993cited by this paper
• HTLV-1 Tax induces expression of various immediate early serum responsive genes.

  1991cited by this paper
• The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells

  1990cited by this paper
• HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene.

  1990cited by this paper
• Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

  1990cited by this paper
• Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

  1989cited by this paper
• Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

  1989cited by this paper
• A unique enhancer element for the trans activator (p40tax) of human T-cell leukemia virus type I that is distinct from cyclic AMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements

  1989cited by this paper
• c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

  1988cited by this paper
• Recent advances in the molecular biology of HTLV-1: trans-activation of viral and cellular genes.

  1987cited by this paper
• The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice.

  1987cited by this paper
• A transgenic mouse model for human neurofibromatosis.

  1987cited by this paper
• Induction of interleukin 2 receptor gene expression by p40x encoded by human T‐cell leukemia virus type 1.

  1986cited by this paper
• Increased mutation frequency after herpes simplex virus type 2 infection in non-permissive XC cells.

  1985cited by this paper
• Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor.

  1985cited by this paper
• The x gene is essential for HTLV replication.

  1985cited by this paper
• The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.

  1985cited by this paper
• Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.

  1984cited by this paper
• Identification of a protein (p40x) encoded by a unique sequence pX of human T-cell leukemia virus type I.

  1984cited by this paper
• Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells

  1984cited by this paper
• Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

  1984cited by this paper
• Cellular oncogenes and multistep carcinogenesis.

  1983cited by this paper
• Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

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  1982cited by this paper
• Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies

  1981cited by this paper
• Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

  1981cited by this paper
• Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies.

  1981cited by this paper
• Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

  1980cited by this paper
• Quantitative studies of radiation transformation with the A31-11 mouse BALB/3T3 cell line.

  1979cited by this paper
• Adult T-cell leukemia: clinical and hematologic features of 16 cases.

  1977cited by this paper
• Microbiologic assays of cancer chemotherapeutic agents.

  1977cited by this paper

• Transcriptional Activation Mechanisms and Target Genes of the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1

  2025cites this paper
• HTLV-1 persistence and the oncogenesis of adult T-cell leukemia/lymphoma

  2023cites this paper
• Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation

  2021cites this paper
• Synthetic antibody discovery against native antigens by CRISPR/Cas9-library generation and endoplasmic reticulum screening

  2020cites this paper
• Mechanisms of Oncogenesis by HTLV-1 Tax

  2020cites this paper
• Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid

  2015influential citation
• HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model".

  2015cites this paper
• Modulation of DNA Damage and Repair Pathways by Human Tumour Viruses

  2015cites this paper
• Rôle des protéines AID et Bfl-1 dans les processus d'instabilité génomique et de survie cellulaire induits par l'oncoprotéine Tax au cours de la lymphomagénèse associée à l'infection par HTLV-1

  2014cites this paper
• Pleiotropic Functions of HTLV-1 Tax Contribute to Cellular Transformation

  2013cites this paper
• Activation of WIP1 Phosphatase by HTLV-1 Tax Mitigates the Cellular Response to DNA Damage

  2013cites this paper
• HTLV-1 Infection and Its Associated Diseases

  2012cites this paper
• Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 Perspective

  2012cites this paper
• Co-infections HTLV-1-Strongyloides stercoralis

  2011cites this paper
• The HTLV-1 Tax oncoprotein represses Ku80 gene expression.

  2011cites this paper
• Anti-Apoptotic Effect of Tax: An NF-κB Path or a CREB Way?

  2011cites this paper
• Molecular analysis of HTLV-2 APH-2 in viral transformation, persistence and host immune response

  2011cites this paper
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  2010cites this paper
• The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

  2010cites this paper
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  2010cites this paper
• HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death.

  2010cites this paper
• overexpression of the chemokine I-309 Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by

  2010cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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• Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells.

  2002influential citation
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  2002cites this paper
• Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.

  2001cites this paper
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  2001cites this paper
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• Analysis of p 53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model

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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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• Suppression of DNA Repair by HTLV Type 1 Tax Correlates with Tax trans-Activation of Proliferating Cell Nuclear Antigen Gene Expression

  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000influential citation
• Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks*

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• HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity.

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• Suppression of DNA Repair by Human T Cell Leukemia Virus Type 1 Tax Is Rescued by a Functional p53 Signaling Pathway*

  2000cites this paper
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  2000cites this paper
• Taxing the cellular capacity for repair: human T-cell leukemia virus type 1, DNA damage, and adult T-cell leukemia.

  1999cites this paper
• Virus-associated lymphomas.

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