Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  American Journal of Respiratory and Critical Care Medicine

• Publication date

  2001-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1164/AJRCCM.164.5.2010104PMID 11549542
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Superoxide Dismutase and Catalase Do Not Affect the Pulmonary Hypertensive Response to Group B Streptococcus in the Lamb

  2001cited by this paper
• Pulmonary hypertension alters soluble guanylate cyclase activity and expression in pulmonary arteries isolated from fetal lambs

  2001cited by this paper
• Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group.

  2000cited by this paper
• Clinical approach to inhaled nitric oxide therapy in the newborn with hypoxemia.

  2000cited by this paper
• Relaxant Effects of Carbon Monoxide Compared with Nitric Oxide in Pulmonary and Systemic Vessels of Newborn Piglets

  2000cited by this paper
• Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia.

  1999cited by this paper
• The cGMP-specific phosphodiesterase inhibitor E4021 dilates the pulmonary circulation.

  1999cited by this paper
• Improved pulmonary distribution of recombinant human Cu/Zn superoxide dismutase, using a modified ultrasonic nebulizer

  1999cited by this paper
• Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: a role for superoxide.

  1998cited by this paper
• Stimulation of soluble guanylate cyclase by superoxide dismutase is mediated by NO.

  1998cited by this paper
• Pulmonary and Systemic Effects of the Phosphodiesterase Inhibitor Dipyridamole in Newborn Lambs with Persistent Pulmonary Hypertension

  1998cited by this paper
• A New Pathway of Nitric Oxide/Cyclic GMP Signaling InvolvingS-Nitrosoglutathione*

  1998cited by this paper
• Superoxide released to high intra-arteriolar pressure reduces nitric oxide-mediated shear stress- and agonist-induced dilations.

  1998cited by this paper
• Cyclic-GMP-Binding, Cyclic-GMP-Specific Phosphodiesterase (PDE5) Gene Expression Is Regulated during Rat Pulmonary Development

  1998cited by this paper
• Recombinant human superoxide dismutase reduces lung injury caused by inhaled nitric oxide and hyperoxia.

  1997cited by this paper
• Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group.

  1997cited by this paper
• Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn

  1997cited by this paper
• Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome.

  1997cited by this paper
• Pulmonary soluble guanylate cyclase, a nitric oxide receptor, is increased during the perinatal period.

  1997cited by this paper
• Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension.

  1997cited by this paper
• Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure.

  1997cited by this paper
• Safety and pharmacokinetics of recombinant human superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome.

  1996cited by this paper
• The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide.

  1995cited by this paper
• Combined effects of nitric oxide and hyperoxia on surfactant function and pulmonary inflammation.

  1995cited by this paper
• Disruption of cGMP production in pulmonary arteries isolated from fetal lambs with pulmonary hypertension.

  1995cited by this paper
• Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.

  1994cited by this paper
• Treatment of persistent pulmonary hypertension in the newborn lamb by inhaled nitric oxide.

  1993cited by this paper
• Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn.

  1993cited by this paper
• Effect of nitric oxide on the survival rate and incidence of lung injury in newborn lambs with persistent pulmonary hypertension.

  1993cited by this paper
• Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide.

  1993cited by this paper
• The Effect of Hyperoxic Exposure on Antioxidant Enzyme Activities of Alveolar Type II Cells in Neonatal and Adult Rats

  1992cited by this paper
• Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth.

  1990cited by this paper
• Ligating the Ductus Arteriosus before Birth Causes Persistent Pulmonary Hypertension in the Newborn Lamb

  1989cited by this paper
• Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs.

  1989cited by this paper
• Ligating the Ductus Arteriosus before birth Remodels the Pulmonary Vasculature of the Lamb

  1989cited by this paper
• Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation.

  1987cited by this paper
• The structural basis of persistent pulmonary hypertension of the newborn infant.

  1981cited by this paper

• Oxidative stress in pediatric diseases associated with the origin of life and growth and development

  2025cites this paper
• Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle—Implications for hypoxic pulmonary hypertension

  2023cites this paper
• New Therapeutic Targets in Neonatal Pulmonary Hypertension

  2022cites this paper
• NO-dependent vasodilation and deep tumor penetration for cascade-amplified antitumor performance.

  2022cites this paper
• Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.

  2021cites this paper
• World Trade Center-Cardiorespiratory and Vascular Dysfunction: Assessing the Phenotype and Metabolome of a Murine Particulate Matter Exposure Model

  2020cites this paper
• Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches

  2020cites this paper
• The role of gasotransmitters in neonatal physiology.

  2019cites this paper
• Redox Regulation of Ion Channels and Receptors in Pulmonary Hypertension

  2019cites this paper
• Therapies that enhance pulmonary vascular NO-signaling in the neonate.

  2019cites this paper
• Oxygen radical disease in the newborn, revisited: Oxidative stress and disease in the newborn period.

  2019cites this paper
• Recombinant Human Superoxide Dismutase and N-Acetylcysteine Addition to Exogenous Surfactant in the Treatment of Meconium Aspiration Syndrome

  2019cites this paper
• Cytoskeletal remodeling and regulation of cell fate in the hypertensive neonatal pulmonary artery in response to stress

  2018cites this paper
• Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn

  2018cites this paper
• Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency.

  2017cites this paper
• Contribution of reactive oxygen species to the pathogenesis of pulmonary arterial hypertension

  2017cites this paper
• Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.

  2016cites this paper
• Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates

  2016cites this paper
• Intratracheal instillation of ethyl pyruvate nanoparticles prevents the development of shunt-flow-induced pulmonary arterial hypertension in a rat model

  2016cites this paper
• adult rat smooth muscle contraction in the newborn but not exposure enhances vascular and airway

  2015cites this paper
• Hyperoxia Inhibits Nitric Oxide Treatment Effects in Alveolar Epithelial Cells via Effects on L-Type Amino Acid Transporter-1

  2014cites this paper
• Rescue Treatment with L-Citrulline Inhibits Hypoxia-Induced Pulmonary Hypertension in Newborn Pigs.

  2014cites this paper
• The Role of Genetic Polymorphisms in Antioxidant Enzymes and Potential Antioxidant Therapies in Neonatal Lung Disease

  2014cites this paper
• Altered Pulmonary Artery Endothelial - Smooth Muscle Cell Interactions in Experimental Congenital Diaphragmatic Hernia

  2014cites this paper
• Update on PPHN: mechanisms and treatment.

  2014cites this paper
• Persistent Pulmonary Hypertension of the Newborn

  2014cites this paper
• Studies on Respiratory Disorders

  2014cites this paper
• Pulmonary Arterial Hypertension and Oxidative Stress

  2014cites this paper
• Yet to Come Reactive Oxygen Species in Pulmonary Vascular Remodeling Comprehensive Physiology Inflammation Shear stress Hypoxia Contractile phenotypic markers Proliferative phenotypic markers Altered Ca 2 + homeostasis Vascular SMC SMC contraction and proliferation Growth factors Pulmonary vascular

  2013influential citation
• Antenatal betamethasone improves postnatal transition in late preterm lambs with persistent pulmonary hypertension of the newborn

  2013cites this paper
• Nitric oxide deficiency in pulmonary hypertension: Pathobiology and implications for therapy

  2013cites this paper
• Reactive oxygen species in pulmonary vascular remodeling.

  2013cites this paper
• Diagnosis and treatment of pulmonary hypertension in infancy.

  2013cites this paper
• Reactive Oxygen Species-Reducing Strategies Improve Pulmonary Arterial Responses to Nitric Oxide in Piglets with Chronic Hypoxia-Induced Pulmonary Hypertension

  2013cites this paper
• Physiology of transition from intrauterine to extrauterine life.

  2012cites this paper
• Hypoxia and Hyperoxia

  2012cites this paper
• The pulmonary circulation in neonatal respiratory failure.

  2012cites this paper
• Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn.

  2012cites this paper
• Physiology of Nitric Oxide in the Developing Lung

  2011cites this paper
• Advances in the Management of Pediatric Pulmonary Hypertension

  2011cites this paper
• Epigenetic regulation of pulmonary arterial hypertension

  2011cites this paper
• Chapter 48 – Diseases of Pulmonary Circulation

  2011cites this paper
• Pediatric pulmonary arterial hypertension: current and emerging therapeutic options

  2011influential citation
• Therapeutic approaches using nitric oxide in infants and children.

  2011cites this paper
• Sustained Lung Activity of a Novel Chimeric Protein, SOD2/3, Following Intratracheal Administration

  2011cites this paper
• The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress

  2011cites this paper
• Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension: A Basis for Excessive Cell Proliferation and a New Therapeutic Target

  2010cites this paper
• Neonatal pulmonary hypertension

  2010cites this paper
• Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration.

  2010cites this paper
• Nitric Oxide and Inhaled Pulmonary Vasodilators

  2010cites this paper
• Oxygen Concentration and Pulmonary Hemodynamics in Newborn Lambs With Pulmonary Hypertension

  2009cites this paper
• Impaired Voltage Gated Potassium Channel Responses in a Fetal Lamb Model of Persistent Pulmonary Hypertension of the Newborn

  2009cites this paper
• Pulmonary Endothelial Control of the Pulmonary Microcirculation

  2009cites this paper
• Bringing down the ROS: a new therapeutic approach for PPHN.

  2008cites this paper
• Nitric oxide and beyond: new insights and therapies for pulmonary hypertension

  2008cites this paper
• Pharmacotherapy for meconium aspiration

  2008cites this paper
• Perfluorochemical augmented rhSOD delivery attenuates inflammation in the immature lung

  2008cites this paper
• Chapter 12 – New Developments in the Pathogenesis and Management of Neonatal Pulmonary Hypertension

  2008cites this paper
• Betamethasone Attenuates Oxidant Stress in Endothelial Cells from Fetal Lambs with Persistent Pulmonary Hypertension

  2008cites this paper
• Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension.

  2007influential citation
• Current drug targets and future therapy of pulmonary arterial hypertension.

  2007cites this paper
• The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow.

  2007cites this paper
• Pulmonary Hypertension in the Neonate

  2007cites this paper
• Recent Advances in the Pathogenesis and Treatment of Persistent Pulmonary Hypertension of the Newborn

  2007cites this paper
• Pediatric Pulmonary Hypertension : Diagnosis And Management In The Acute Care Setting

  2007cites this paper
• Inhaled NO as a therapeutic agent.

  2007cites this paper
• Antioxidant Strategies in Respiratory Medicine

  2006cites this paper
• Interaction of KATP Channels and Endothelin-1 in Lambs With Persistent Pulmonary Hypertension of the Newborn

  2006cites this paper
• Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension.

  2006cites this paper
• Pulmonary hypertension in children: the twenty-first century.

  2006cites this paper
• Persistent Pulmonary Hypertension of the Newborn: Pathophysiology and Treatment

  2006cites this paper
• Superoxide auto-augments superoxide formation and upregulates gp91(phox) expression in porcine pulmonary artery endothelial cells: inhibition by iloprost.

  2006cites this paper
• Effects of Prostacyclin and Milrinone on Pulmonary Hemodynamics in Newborn Lambs With Persistent Pulmonary Hypertension Induced by Ductal Ligation

  2006cites this paper
• Acute hypoxia simultaneously induces the expression of gp91phox and endothelial nitric oxide synthase in the porcine pulmonary artery

  2005cites this paper
• Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs.

  2005cites this paper
• Antioxidant treatment for lung diseases

  2005cites this paper
• Efecto de los isoprostanos en la reactividad vascular pulmonar y sistémica durante el período neonatal.

  2005cites this paper
• Pre- and postnatal factors in chronic lung disease: implications for management.

  2004cites this paper
• Chapter 65 – Developmental Biology of the Pulmonary Vasculature

  2004cites this paper
• New approaches for persistent pulmonary hypertension of newborn.

  2004cites this paper
• Endothelial dysfunction and reactive oxygen species production in ischemia/reperfusion and nitrate tolerance.

  2004cites this paper
• Oxidative stress in severe pulmonary hypertension.

  2004cites this paper
• Molecular mechanisms of nitric oxide-induced growth arrest and apoptosis in fetal pulmonary arterial smooth muscle cells.

  2003cites this paper
• Role of Superoxide Anion on Basal and Stimulated Nitric Oxide Activity in Neonatal Piglet Pulmonary Vessels

  2003cites this paper
• Chronic O2 exposure enhances vascular and airway smooth muscle contraction in the newborn but not adult rat.

  2003cites this paper
• Nitric oxide for preemies--not so fast.

  2003cites this paper
• Role of Reactive Oxygen Species in Vascular Remodeling Associated with Pulmonary Hypertension

  2003influential citation
• Role of oxidant injury in the pathogenesis of neonatal lung disease

  2002influential citation
• Altered guanylyl-cyclase activity in vitro of pulmonary arteries from fetal lambs with congenital diaphragmatic hernia.

  2002cites this paper
• The role of endogenous and exogenous nitric oxide on airway function.

  2002cites this paper
• Chronic obstructive pulmonary disease, pollution, pulmonary vascular disease, transplantation, pleural disease, and lung cancer in AJRCCM 2001.

  2002cites this paper
• Chronic obstructive pulmonary disease, pollution, pulmonary vascular disease, transplantation, pleural disease, and lung cancer in AJRCCM 2000.

  2001cites this paper