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Mucuna pruriens seed protects the hippocampal neurons and abrogates seizure indices in chemically-convulsed mice: evidence of the Nrf2 expression defense pathway.

O. Osuntokun,G. Olayiwola,Ayomide Karimat Oriare,Samuel Oyeyemi Oyedokun,T. Abayomi,O. S. Tokunbo,A. Ayoka

Published 2022 in Journal of Chemical Neuroanatomy

ABSTRACT

The anticonvulsant mechanisms and neuroprotective effects of Mucuna pruriens (MP) seed in male BALB/c mice were evaluated. Ninety mice were kindled with picrotoxin, strychnine, or pilocarpine hydrochloride at the 30th minute of intraperitoneal injection (i.p) of normal saline (0.2ml), MP (200, 100, 50mg/kg), diazepam (7.5mg/kg), or haloperidol (5mg/kg). The onset of convulsion and percentage mortality was recorded. The histoarchitectural and immunohistochemical profiles of the brains were determined. Data were expressed as mean ± SEM with a one-way analysis of variance (ANOVA), while p < 0.05 was considered significant. There was a significant prolongation of the latency to first seizure across the treatment groups following picrotoxin, and pilocarpine-induced convulsion; a decrease in percentage mortality in the MP (50mg/kg) treatment group, and an increase in the hippocampal nuclear factor erythroid 2-related factor 2 count, and Neu-N expression in the MP (200mg/kg, and 100mg/kg) treated mice. Treatment with MP seed may abolish seizure occurrence and consequential mortality; mechanisms traceable to its GABAergic expression and hippocampal NRF 2 and Neu N expression.

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