Synthesis of Novel Bis(Sulfanediyl)Bis(Tetrahydropyrimido[4,5-b]Quinoline-4,6-Diones) Linked to Butenyl and Butynyl Spacers via Thioether Linkages

Abstract A synthesis of novel bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) connected to butenyl and butynyl spacers via thioether linkages is reported. Two equivalents of the appropriate aldehyde and dimedone were used in a multicomponent reaction with the corresponding bis(6-aminopyrimidin-4(3H)-ones) to produce the target products. Bis(alkylation) of the appropriate 2-thioxohexahydropyrimido[4,5-b]quinoline-4,6-dione in ethanolic potassium hydroxide with 1,4-dichlorobut-2-ene or 1,4-dibromobut-2-yne also produced the target compounds. Furthermore, bis(tetrahydropyrimido[4,5-b]quinolinetriones) linked to olefinic or acetylenic spacers via ether linkage were synthesized in high yields by a three-component reaction of the appropriate bis(aldehydes) with two equivalents of both 6-aminothiouracil and dimedone.

• Publication year

  2022

• Venue

  Polycyclic aromatic compounds (Print)

• Publication date

  2022-05-31

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1080/10406638.2022.2083192
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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