Comparative Quantification of Diffusion Tensor Tractography Using Automated Whole Brain MRI Tractography for Intracranial Tumor Surgery: Technical Note

With the improvement of diffusion tensor imaging (DTI) and algorithms, diffusion tensor tractography (DTT) may provide quantitative information on white matter tracts (WMT) that may help quantitatively assess WMT integrity and distortion, which may help with correlations of neurologic function or prognosis. This manuscript is the first to describe a technical method for quantitative analysis of clinically relevant white matter tracts during intracranial tumor surgery. The authors quantitatively analyzed relevant proximal WMT, pre and postoperatively, in a patient undergoing cranial surgery using DTT software to evaluate fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), geodesic anisotropy (GA), tract count, and tract volume. A method was then established to formulate quantitative comparisons between pre and postoperative WMT. Quantitative assessment of the corticospinal and optic radiation tracts revealed significant increases in the FA, GA, and tract count in the corticospinal and optic radiations postoperatively (p<.0001). MD, RD, and AD were found to be significantly diminished postoperatively (p<.0001). The postoperative optic radiations showed diminished volume as a result of damage to the tract pathway. To conclude, the utilization of white matter tractography provides a technical advancement that allows for quantitative comparative assessments of white matter tracts, which could assess the degree of brain changes following tumor surgery.

• Publication year

  2022

• Venue

  Cureus

• Publication date

  2022-05-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.7759/cureus.25546PMID 35800828PMCID 9246502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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