Diagnostic and prognostic implications of mast cell microenvironment in smooth muscle tumors of the uterine corpus

Mast cells can be found almost everywhere throughout the human body, even in some benign soft tissue tumors (e.g. neurofibroma) and their presence within gynecological tumors has been well known for several decades. However, the prognostic role of their presence in various tumors is not yet understood as several scientific studies reveal contradictory information with both positive and negative correlation between the number of mast cells and tumor aggressiveness. In recent years, some authors reported that increased numbers of mast cell in the background of cervical and endometrial carcinomas are usually correlated with a worse prognosis when compared to similar histopathologic lesions with no mast cell microenvironment. On the other hand, similar studies regarding ovarian and breast carcinoma demonstrated strong positive correlation between increased mast cell numbers and favorable outcome. Therefore, we now have increasing evidence showing that mast cells tend to gather within and around neoplastic proliferations and could either promote or inhibit tumoral growth, based on regional stromal environment. In this article we aim to evaluate the mast cell microenvironment in smooth muscle tumors of the uterine corpus and attempt to establish their diagnostic implications and prognostic value.

• Publication year

  2021

• Venue

  Romanian Medical Journal

• Publication date

  2021-12-30

• Fields of study

  Not labeled

• Identifiers
  DOI 10.37897/rmj.2021.s6.11
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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