The histopathological changes induced by intra peritoneal administration of cerium oxide on mice brain tissue

The use of nanoparticles (NPs) and nanoparticle- based materials raises many concerns about their impact on health related to its many applications in diverse fields, including petroleum refining, polishing agents, and coatings, as well as the toxicity of these NPs in biological/ physiological environment is a major concern. The study conducted at college of nursing – university of Basrah –Iraq,and it aimed to investigated the effect of cerium oxide nanoparticles on mice brain tissues after 30 days of intra-peritoneal I/P injection of cerium oxide nanoparticles . White laboratory mice of Mus musculus L. strain BALB/C that were supplied from (Drug Control Center - College of Science, Thi -Qar University). The mice were placed under controlled conditions of 20-25 degrees and a 12-hour light cycle. And 12 hours of darkness in plastic cages of standard sizes (30×12×11) cm, the first group injected laboratory mice with 1 ml of normal saline physiological solution as a control group. The second treatment group. Laboratory mice were injected with 1 ml of cerium dioxide at a concentration of 3.75 µl of the raw material to 996.25 µl of physiological solution. By one injection between one day and another for a period of 30 days to investigate the effects of I/P administration of cerium oxide Nano- particles on mice brain tissue after 30 day. Mice were killed and brain isolated to prepare for the histological examination which showed that cerium oxide injected for 30 day induce pathological alteration in brain tissue especially on white matter , neurofibers and glial cells. Brain of mice show degeneration of white matter, ,necrosis of glial cell aggregation of glial cell , The histopathological examination investigate that intra-peritoneal injection in mice for thirty day induce histopathological adverse changes in mice brain tissue.

• Publication year

  2022

• Venue

  World Journal of Advanced Research and Reviews

• Publication date

  2022-05-30

• Fields of study

  Not labeled

• Identifiers
  DOI 10.30574/wjarr.2022.14.2.0418
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Assessment of teachers' knowledge about first aid.

  2020cited by this paper
• Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety.

  2017cited by this paper
• Rare Earth Elements in Human and Environmental Health: At the Crossroads Between Toxicity and Safety

  2016cited by this paper
• Recent advances of cerium oxide nanoparticles in synthesis, luminescence and biomedical studies: a review

  2015cited by this paper
• Cerium Oxide Nanoparticles Induced Toxicity in Human Lung Cells: Role of ROS Mediated DNA Damage and Apoptosis

  2014cited by this paper
• The role of ceria-based nanostructured materials in energy applications

  2014cited by this paper
• Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats.

  2011cited by this paper
• Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles.

  2010cited by this paper
• Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice.

  2008cited by this paper
• Radical nanomedicine.

  2006cited by this paper
• Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm.

  2006cited by this paper
• Cerium Mischmetal, Cerium Alloys, and Cerium Compounds

  2000cited by this paper

• No citing papers are available for this paper.