SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Naunyn-Schmiedeberg's Archives of Pharmacology

• Publication date

  1992-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF00176615PMID 1620241
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

  1997cited by this paper
• SDZ 205-557, a selective antagonist at 5-HT4 receptors in the isolated guinea pig ileum.

  1991cited by this paper
• Piglet sinoatrial 5-HT receptors resemble human atrial 5-HT4-like receptors

  1990cited by this paper
• The differential activities of R ( )- and S(-)-zacopride as 5-HT3 receptor antagonists.

  1990cited by this paper
• Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor.

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• 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum

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• β-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test

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• A 5‐hydroxytryptamine receptor in human atrium

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• Cardiovascular Pharmacology of 5-Hydroxytryptamine

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• Agonists and antagonists of 5-HT3 receptors

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• The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons

  1989cited by this paper
• 5-Hydroxytryptamine antagonist ICS 205-930 blocks cardiac potassium, sodium and calcium currents.

  1988cited by this paper
• A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system.

  1988cited by this paper
• Molecular pharmacology of 5-HT1D recognition sites: Radioligand binding studies in human, pig and calf brain membranes

  1988cited by this paper
• Benzamides and cholinesterases.

  1987cited by this paper
• Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine.

  1986cited by this paper
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  1985cited by this paper
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  1985cited by this paper
• Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach

  1985cited by this paper
• Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum

  1985cited by this paper
• Two types of receptors for 5‐hydroxytryptamine on the cholinergic nerves of the guinea‐pig myenteric plexus

  1985cited by this paper
• How should values of pA2 and affinity constants for pharmacological competitive antagonists be estimated?

  1978cited by this paper
• General Theory of Drug-Receptor Interactions

  1977cited by this paper

• Melatonin in plant morphogenesis

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• A Brief Summary for 5-HT Receptors

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• GASTROINTESTINAL MOTILITY, PROKINETIC BENZAMIDES AND SEROTONIN

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• HETEROGENOUS PHASE AS A MEAN IN COMBINATORIAL CHEMISTRY

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• Effect of tegaserod on esophageal pain threshold, regurgitation, and symptom relief in patients with functional heartburn and mechanical sensitivity.

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• New Oxadiazole Derivatives Showing partly Antiplatelet, Antithrombotic and Serotonin Antagonistic Properties

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  2004cites this paper
• 5-HT4 receptor ligands: applications and new prospects.

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• 5‐HT4 Receptor Ligands: Applications and New Prospects

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• 5‐HT4 receptors exert a frequency‐related facilitatory control on dorsal raphé nucleus 5‐HT neuronal activity

  2002influential citation
• 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist.

  2002cites this paper
• 5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions.

  2002cites this paper
• The pharmacokinetics of the novel promotile drug, tegaserod, are similar in healthy subjects—male and female, elderly and young

  2001cites this paper
• Roles of 5-HT receptors in the release and action of secretin on pancreatic secretion in rats.

  2001cites this paper
• Chronotropic action of 5-hydroxytryptamine (5-HT) on colonic migrating motor complexes (CMMCs) in the isolated mouse colon.

  2000cites this paper
• Synthesis and preliminary pharmacological results on new naphthalene derivatives as 5-HT(4) receptor ligands.

  2000cites this paper
• Facilitation of acetylcholine release by SK-951, a benzofuran derivative, via the 5-hydroxytryptamine4 receptor in guinea pig stomach.

  2000cites this paper
• Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors.

  1999cites this paper
• Benzimidazole derivatives. Part 1: Synthesis and structure-activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists.

  1999cites this paper
• Effect of TKS159, a novel 5‐hydroxytryptamine4 agonist, on gastric contractile activity in conscious dogs

  1998cites this paper
• 5‐Hydroxytryptamine‐induced Secretion by Rat Jejunum In‐vitro Involves Several 5‐Hydroxytryptamine Receptor Subtypes

  1998cites this paper
• Medicinal Chemistry of 5-HT4 Receptor Ligands

  1998cites this paper
• fnvolves Several 5-HydroxytryptarnincRecept6r Subtypes

  1998cites this paper
• Effects of ondansetron on electrically evoked contraction in rat stomach fundus: possible involvement of 5-HT2B receptors.

  1997cites this paper
• Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro.

  1997cites this paper
• Arylcarbamate derivatives of 1-piperidineethanol as potent ligands for 5-HT4 receptors.

  1997cites this paper
• New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.

  1997cites this paper
• Serotonin 5‐HT3 and 5‐HT4 receptor antagonists

  1997cites this paper
• Several Receptor Subtypes Contribute to 5‐Hydroxytryptamine‐induced Secretion by Rat Ileum In‐vitro

  1997cites this paper
• Investigation into the contractile response of melatonin in the guinea‐pig isolated proximal colon: the role of 5‐HT4 and melatonin receptors

  1997cites this paper
• Pharmacological characterization of the 5‐hydroxytryptamine receptor mediating relaxation in the rat isolated ileum

  1996cites this paper
• Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.

  1996cites this paper
• Ability of 5‐HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo

  1996cites this paper
• Identification of putative 5-hydroxytryptamine(4) (5-HT4) receptors in guinea pig stomach: The effect of TKS159, a novel agonist, on gastric motility and acetylcholine release.

  1996cites this paper
• A comparative study of functional 5‐HT4 receptors in human colon, rat oesophagus and rat ileum

  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
• Central 5-HT4 receptors.

  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
• Drugs affecting serotonin receptors.

  1994cites this paper
• Mediation by 5‐HT1D receptors of 5‐hydroxytryptamine‐induced contractions of rabbit middle and posterior cerebral arteries

  1994cites this paper
• GR113808: a novel, selective antagonist with high affinity at the 5‐HT4 receptor

  1994cites this paper
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  1994cites this paper
• Quantitative autoradiography of 5-HT4 receptors in brains of three species using two structurally distinct radioligands, [3H]GR113808 and [3H]BIMU-1.

  1994cites this paper
• 5-HT4 receptors in rat but not guinea pig, rabbit or dog esophageal smooth muscle.

  1994cites this paper
• Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro.

  1994cites this paper
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  1994cites this paper
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  1993cites this paper
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  1993cites this paper
• SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.

  1993cites this paper
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  1993cites this paper
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  1993cites this paper
• (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.

  1993cites this paper
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  1993cites this paper
• [3H]-GR113808 labels 5-HT4 receptors in the human and guinea-pig brain.

  1993cites this paper
• Poster communications.

  1993cites this paper
• The action of SDZ 205,557 at 5‐hydroxytryptamine (5‐HT3 and 5‐HT4) receptors

  1993cites this paper
• Development of a radioligand binding assay for 5‐HT4 receptors in guinea‐pig and rat brain

  1993cites this paper
• Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist.

  1993cites this paper
• Characterization of the 5‐HT4 receptor mediating tachycardia in piglet isolated right atrium

  1993cites this paper
• 5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle.

  1992cites this paper
• Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285

  1992cites this paper
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  1992cites this paper