Tumor suppressive effect of Artemisia annua extract in 7, 12-dimethylbenz[a]anthracene-induced breast cancer in Wistar rats

recently suggested to be used in combination with anticancer therapy. Therefore, this study was planned and designed to chemically simulate a model of breast cancer using 7, 12-dimethylbenz[a]anthracene (DMBA) and monitor the genetic and immunohistochemical effects of A. annua extract on this model. Nkap is a 47 kD, nuclear protein involved in NF ABSTRACT Objective: This study aimed to detect the genetic and immunohistochemical effects of the extract of Artemisia annua , a popular medicinal herb in a chemical model of breast cancer. Materials and Methods: Breast cancer was induced in female rats by 7, 12-dimethylbenz[a] anthracene (DMBA). The rats were then treated with 100 and 200 mg/kg A. annua extract after 4 months of DMBA administration, and the genetic and immunohistochemical effects of A. annua extract were examined on DMBA-induced breast cancer. Results: We observed the upregulation of Nkap , proliferating cell nuclear antigen , and phosphoinositide-dependent protein kinase 1 genes in DMBA administered rats, which were significantly normalized in the treated groups, particularly with 100 and 200 mg/kg of A. annua extract. A significant decrease in p53 expression was detected in DMBA administered rats, which was normalized in the treated groups ( P < 0.05). Further, the expression of calponin-h2 was enhanced, and that of p63 was declined in the breast tissue of DMBA administered rats, and both levels were normalized in the treated groups. Conclusion: We recommend the use of A. annua extract as a promising complementary drug in breast cancer treatment.

• Publication year

  2020

• Venue

  The Thai Journal of Pharmaceutical Sciences

• Publication date

  2020-01-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.56808/3027-7922.2458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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