Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Virchows Archiv

• Publication date

  2015-03-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00428-015-1745-4PMID 25742908
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver cirrhosis.

  2014cited by this paper
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  2014cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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  1954cited by this paper
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