Chemically Precise Glycoengineering Improves Human Insulin.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  ACS Chemical Biology

• Publication date

  2017-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acschembio.7b00794PMID 29090903PMCID PMC6287623
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural Insight into the Stabilizing Effect of O-Glycosylation.

  2017cited by this paper
• Chemical synthesis of peptides within the insulin superfamily

  2016cited by this paper
• Exome sequencing a review of new strategies for rare genomic disease research.

  2016cited by this paper
• Pursuit of a perfect insulin

  2016cited by this paper
• Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis.

  2016cited by this paper
• Chemical synthesis of erythropoietin glycoforms for insights into the relationship between glycosylation pattern and bioactivity

  2016cited by this paper
• The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.

  2016cited by this paper
• Total synthesis of glycosylated proteins.

  2015cited by this paper
• Molecular-scale features that govern the effects of O-glycosylation on a carbohydrate-binding module† †This manuscript is dedicated to Professor Samuel J. Danishefsky. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02636a Click here for additional data file.

  2015cited by this paper
• Probing insulin bioactivity in oral nanoparticles produced by ultrasonication-assisted emulsification/internal gelation

  2015cited by this paper
• Use of insulin in type 2 diabetes: what we learned from recent clinical trials on the benefits of early insulin initiation.

  2014cited by this paper
• Recent strategies targeting HIV glycans in vaccine design.

  2014cited by this paper
• Enhancing the Oral Bioavailability of Peptide Drugs by using ChemicalModification and Other Approaches

  2014cited by this paper
• Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein.

  2014cited by this paper
• Emerging Trends in Noninvasive Insulin Delivery

  2014cited by this paper
• A Brief History of the Development of Diabetes Medications

  2014cited by this paper
• Cell factories for insulin production

  2014cited by this paper
• A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

  2014cited by this paper
• Synthesis of and specific antibody generation for glycopeptides with arginine N-GlcNAcylation.

  2014cited by this paper
• Strategic Approaches to Optimizing Peptide ADME Properties

  2014cited by this paper
• Specificity of O-glycosylation in enhancing the stability and cellulose binding affinity of Family 1 carbohydrate-binding modules

  2014cited by this paper
• Oral Insulin Delivery: How Far are We?

  2013cited by this paper
• Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.

  2013cited by this paper
• Adherence to Therapies in Patients with Type 2 Diabetes

  2013cited by this paper
• Fully convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography.

  2013cited by this paper
• Concise synthetic routes to human insulin.

  2013cited by this paper
• Erythropoietin Derived by Chemical Synthesis

  2013cited by this paper
• Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present.

  2012cited by this paper
• N‐glycosylation of enhanced aromatic sequons to increase glycoprotein stability

  2012cited by this paper
• Evolution of Insulin Development: Focus on Key Parameters

  2012cited by this paper
• Design of Non-Standard Insulin Analogs for the Treatment of Diabetes Mellitus

  2012cited by this paper
• Chemical biology of glycosylphosphatidylinositol anchors.

  2012cited by this paper
• Oral Delivery of Insulin: Novel Approaches

  2012cited by this paper
• The Chemical Synthesis of Insulin: From the Past to the Present

  2011cited by this paper
• Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery.

  2011cited by this paper
• Faculty Opinions recommendation of Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin.

  2010cited by this paper
• Oral Insulin

  2010cited by this paper
• Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.

  2010cited by this paper
• Insights into the finer issues of native chemical ligation: an approach to cascade ligations.

  2010cited by this paper
• Oral insulin – a review of current status

  2010cited by this paper
• Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation

  2010cited by this paper
• Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin.

  2010cited by this paper
• Essentials of glycobiology

  2009cited by this paper
• Glycoengineering of Erythropoietin

  2009cited by this paper
• Oral Insulin: The Rationale for This Approach and Current Developments

  2009cited by this paper
• Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain.

  2009cited by this paper
• Glycoprotein synthesis: an update.

  2009cited by this paper
• The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability

  2009cited by this paper
• How insulin regulates glucose transport in adipocytes.

  2009cited by this paper
• Effects of glycosylation on the stability of protein pharmaceuticals.

  2009cited by this paper
• Insulin Releases Glut4 from Static Storage Compartments into Cycling Endosomes and Increases the Rate Constant for Glut4 Exocytosis*

  2008cited by this paper
• Analytical ultracentrifugation: sedimentation velocity and sedimentation equilibrium.

  2008cited by this paper
• Effect of glycosylation on protein folding: A close look at thermodynamic stabilization

  2008cited by this paper
• Quantitative matrix-assisted laser desorption/ionization mass spectrometry.

  2008cited by this paper
• Role of analytical ultracentrifugation in assessing the aggregation of protein biopharmaceuticals

  2006cited by this paper
• Glycopeptides as versatile tools for glycobiology.

  2006cited by this paper
• Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins.

  2005cited by this paper
• Akt activation is required at a late stage of insulin-induced GLUT4 translocation to the plasma membrane.

  2005cited by this paper
• Development and in vivo evaluation of an oral insulin-PEG delivery system.

  2004cited by this paper
• The reality of glycaemic control in insulin treated diabetes: defining the clinical challenges

  2004cited by this paper
• Large-scale manufacture of peptide therapeutics by chemical synthesis

  2003cited by this paper
• Effects of PEG conjugation on insulin properties.

  2002cited by this paper
• GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps.

  2002cited by this paper
• Chemical Glycobiology

  2001cited by this paper
• Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry.

  2000cited by this paper
• Site-specific insulin conjugates with enhanced stability and extended action profile.

  1999cited by this paper
• Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin.

  1995cited by this paper
• Induction of anti-recombinant human granulocyte-macrophage colony-stimulating factor (Escherichia coli-derived) antibodies and clinical effects in nonimmunocompromised patients.

  1994cited by this paper
• Insulin assembly: its modification by protein engineering and ligand binding

  1993cited by this paper
• Recombinant Human Insulin

  1992cited by this paper
• Insulin Aggregation in Aqueous Media and Its Effect on Alpha-Chymotrypsin-Mediated Proteolytic Degradation

  1991cited by this paper
• Degradation of Insulin by Trypsin and Alpha-Chymotrypsin

  1991cited by this paper
• Development of antibodies to unprotected glycosylation sites on recombinant human GM-CSF.

  1990cited by this paper
• Promoting effect of the new chymotrypsin inhibitor FK‐448 on the intestinal absorption of insulin in rats and dogs

  1985cited by this paper

• Molecular engineering of designer diabetes therapeutics.

  2026cites this paper
• Re-engineering insulin for oral delivery: structural modifications, advanced formulation strategies, and future directions

  2026cites this paper
• Deciphering the significant impact of natural glycosylation on human insulin

  2025cites this paper
• Rapid synthesis of glycosylated insulins by flow-based peptide synthesis

  2025cites this paper
• Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering.

  2024cites this paper
• Enhancing Protein Solubility via Glycosylation: From Chemical Synthesis to Machine Learning Predictions.

  2024cites this paper
• Insulin Stabilization Designs for Enhanced Therapeutic Efficacy and Accessibility.

  2024cites this paper
• Engineered therapeutic proteins for sustained-release drug delivery systems.

  2023cites this paper
• Enhancing activity of food protein-derived peptides: An overview of pretreatment, preparation, and modification methods.

  2023cites this paper
• Comparative kinetic characterization of the activity of glycosylated and non-glycosylated trypsin-like serine protease isolated from adults of Rhyzopertha dominica (Coleoptera: Bostrichidae) reared on the grain of three different cultivars of wheat

  2023cites this paper
• Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies.

  2023cites this paper
• Current advances and future prospects in production of recombinant insulin and other proteins to treat diabetes mellitus

  2022cites this paper
• A versatile design platform for glycoengineering therapeutic antibodies

  2022cites this paper
• Strategies for Glycoengineering Therapeutic Proteins

  2022influential citation
• Structural models of viral insulin‐like peptides and their analogs

  2022cites this paper
• Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation

  2021influential citation
• Exploring a combined Escherichia coli-based glycosylation and in vitro transglycosylation approach for expression of glycosylated interferon alpha.

  2021cites this paper
• Chemical (neo)glycosylation of biological drugs.

  2021cites this paper
• Chemical Glycosylation and Its Application to Glucose Homeostasis-Regulating Peptides

  2021cites this paper
• Research fronts of Chemical Biology

  2021cites this paper
• Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2017-2018.

  2021cites this paper
• Omniligase-1-mediated ligation for insulin analog synthesis in solu-tion and on phage surface

  2021cites this paper
• Facile synthesis of insulin fusion derivatives through sortase A ligation

  2020cites this paper
• Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering

  2020cites this paper
• Protein Glycoengineering: An Approach for Improving Protein Properties

  2020cites this paper
• Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence.

  2020cites this paper
• Chemical biology of glycoproteins: From chemical synthesis to biological impact.

  2019cites this paper
• Total Chemical Synthesis of a Non-Fibrillating Human Glycoinsulin.

  2019cites this paper
• Just a spoonful of sugar: Short glycans affect protein properties and functions

  2019cites this paper
• Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analog with Enhanced Stability.

  2019cites this paper
• Chemical synthesis of N‐glycosylated insulin‐like androgenic gland factor from the freshwater prawn Macrobrachium rosenbergii

  2019cites this paper
• Using Chemical Synthesis To Study and Apply Protein Glycosylation.

  2018cites this paper
• Methods for engineering therapeutic peptides

  2018cites this paper
• O-GalNAcylation of RANTES Improves Its Properties as a Human Immunodeficiency Virus Type 1 Entry Inhibitor.

  2018cites this paper