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WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme

Hyuntae Kim,Paolo Panza,Khrievono Kikhi,Yuko Nakamichi,A. Atzberger,S. Guenther,C. Ruppert,A. Guenther,D. Stainier

Published 2022 in Proceedings of the National Academy of Sciences of the United States of America

ABSTRACT

Significance WNT/β-catenin signaling is critical for lung development, and homeostasis and it has also been implicated in inflammatory lung diseases. However, the underlying molecular mechanisms, especially those at play during inflammatory conditions, are unclear. Here, we show that loss of the WNT coreceptor Related to receptor tyrosine kinase (RYK) specifically in mesenchymal cells results in lung inflammation. Our data indicate that RYK signaling through β-catenin and Nuclear Factor kappa B (NF-κB) is part of a safeguard mechanism against mesenchymal cell death, excessive inflammatory cytokine production, and inflammatory cell recruitment and accumulation.

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