Overexpression of aldehyde reductase protects PC12 cells from the cytotoxicity of methylglyoxal or 3-deoxyglucosone.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Biochemistry (Tokyo)

• Publication date

  1998-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/OXFORDJOURNALS.JBCHEM.A021944PMID 9538214
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997influential reference
• Induction of apoptotic cell death by methylglyoxal and 3-deoxyglucosone in macrophage-derived cell lines.

  1996influential reference
• In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites.

  1995cited by this paper
• Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction.

  1994cited by this paper
• Suppression of antioxidative enzyme expression by transforming growth factor-beta 1 in rat hepatocytes.

  1994cited by this paper
• Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.

  1994cited by this paper
• The glyoxalase system in health and disease.

  1993cited by this paper
• Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard reaction, in diabetic serum.

  1993cited by this paper
• The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.

  1993cited by this paper
• Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression.

  1993cited by this paper
• Induction and release of manganese superoxide dismutase from mitochondria of human umbilical vein endothelial cells by tumor necrosis factor-alpha and interleukin-1 alpha.

  1993cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• The metabolism of aminoacetone to methylglyoxal by semicarbazide-sensitive amine oxidase in human umbilical artery.

  1992cited by this paper
• Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.

  1991cited by this paper
• Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase.

  1990cited by this paper
• The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.

  1989cited by this paper
• Acetone Metabolism in Humans During Diabetic Ketoacidosis

  1986cited by this paper
• Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes.

  1985cited by this paper

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