Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles. Evidences for a compensatory mechanism triggered by receptor loss.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Clinical Investigation

• Publication date

  1998-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI1248PMID 9649579PMCID PMC509087
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2008cited by this paper
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  1994cited by this paper
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  1994influential reference
• Myasthenia gravis.

  1994cited by this paper
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  1994cited by this paper
• High-resolution epitope mapping and fine antigenic characterization of the main immunogenic region of the acetylcholine receptor. Improving the binding activity of synthetic analogues of the region.

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  1993influential reference
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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• Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.

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  1989cited by this paper
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• The nicotinic cholinergic receptor: correlation of molecular structure with functional properties.

  1982cited by this paper
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