The role of Wilms' tumor genes.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Medical Investigation

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10687307
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells.

  1998cited by this paper
• Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program

  1998cited by this paper
• Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.

  1998cited by this paper
• Wilms' tumour-suppressor protein isoforms have opposite effects on Igf2 expression in primary embryonic cells, independently of p53 genotype.

  1998cited by this paper
• p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines.

  1998cited by this paper
• Expression of the Wilms' tumor suppressor gene, WT1, is upregulated by leukemia inhibitory factor and induces monocytic differentiation in M1 leukemic cells.

  1998cited by this paper
• Activation of the wt1 Wilms' tumor suppressor gene by NF-κB

  1998cited by this paper
• Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP.

  1997cited by this paper
• Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain

  1997cited by this paper
• p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents.

  1997cited by this paper
• Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor.

  1997cited by this paper
• Wilms tumor gene (wt1) mRNA is equally expressed in blast cells from acute myeloid leukemia and normal CD34+ progenitors.

  1997cited by this paper
• Sp1 Is a Critical Regulator of the Wilms' tumor-1 Gene*

  1997cited by this paper
• A clinical overview of WT1 gene mutations

  1997influential reference
• Induction of p21 by the Wilms' tumor suppressor gene WT1.

  1997cited by this paper
• Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer.

  1997cited by this paper
• Establishment and characterization of two cultured cell lines derived from malignant rhabdoid tumors of the kidney

  1996cited by this paper
• PAX8‐mediated activation of the wt1 tumor suppressor gene.

  1996cited by this paper
• MDR1 and multidrug resistance-associated protein (MRP) gene expression in epithelial ovarian tumors.

  1996cited by this paper
• Expression pattern of WT1 and GATA-1 in AML with chromosome 16q22 abnormalities.

  1996cited by this paper
• Biology of the multidrug resistance-associated protein, MRP.

  1996cited by this paper
• Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter.

  1995cited by this paper
• WT1 induces expression of insulin-like growth factor 2 in Wilms' tumor cells.

  1995cited by this paper
• Expression of mdr-1 in refractory lymphoma: quantitation by polymerase chain reaction and validation of the assay.

  1995cited by this paper
• The drug resistance-related protein LRP is the human major vault protein

  1995cited by this paper
• High rate of MDR‐1 and heterogeneous pattern of MRP expression without gene amplification in endometrial cancer

  1995cited by this paper
• Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

  1995cited by this paper
• WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.

  1995cited by this paper
• G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes.

  1995cited by this paper
• Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, wt1, have altered DNA binding specificity and regulate transcription in different ways.

  1995cited by this paper
• Repression of Pax-2 by WT1 during normal kidney development.

  1995cited by this paper
• Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wt1.

  1995cited by this paper
• GATA-1 Transactivates the WT1 Hematopoietic Specific Enhancer (*)

  1995cited by this paper
• Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.

  1994cited by this paper
• WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia.

  1994cited by this paper
• Downregulation of Wilms' tumor gene (wt1) during myelomonocytic differentiation in HL60 cells.

  1994cited by this paper
• The Wilms' tumor suppressor gene WT1 is negatively autoregulated.

  1994cited by this paper
• Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter.

  1994cited by this paper
• Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product.

  1994cited by this paper
• Wilms' tumor gene, WT1, mRNA is down-regulated during induction of erythroid and megakaryocytic differentiation of K562 cells.

  1994cited by this paper
• Genetics of Wilms' tumor: a blend of aberrant development and genomic imprinting.

  1994cited by this paper
• Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

  1993cited by this paper
• Characterization of the transcriptional regulatory region of the human WT1 gene.

  1993cited by this paper
• WT-1 is required for early kidney development.

  1993cited by this paper
• Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus.

  1993cited by this paper
• WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

  1993cited by this paper
• The Wilms tumour gene WT1 is expressed in murine mesoderm–derived tissues and mutated in a human mesothelioma

  1993cited by this paper
• Expression of multidrug resistance gene (MDR-1) in human normal leukocytes.

  1993cited by this paper
• A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1.

  1993cited by this paper
• Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.

  1992cited by this paper
• Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

  1992cited by this paper
• A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.

  1992cited by this paper
• Expression of the Wilms' tumor gene (WT1) in human leukemias.

  1992cited by this paper
• Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.

  1992influential reference
• Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development

  1991cited by this paper
• Alternative splicing and genomic structure of the Wilms tumor gene WT1.

  1991cited by this paper
• Wilms' tumor: status report, 1990. By the National Wilms' Tumor Study Committee.

  1991cited by this paper
• Transcriptional repression mediated by the WT1 Wilms tumor gene product.

  1991cited by this paper
• Expression of the Wilms' tumor gene WT1 in the murine urogenital system.

  1991cited by this paper
• An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.

  1990cited by this paper
• Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.

  1990cited by this paper
• The candidate Wilms' tumour gene is involved in genitourinary development

  1990cited by this paper
• Secondary leukemia following successful treatment of Wilms' tumor.

  1989cited by this paper
• Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.

  1989influential reference
• Rhabdoid Tumor of Kidney: A Report of 111 Cases from the National Wilms' Tumor Study Pathology Center

  1989cited by this paper
• Genetic linkage of Beckwith-Wiedemann syndrome to 11p15.

  1989cited by this paper
• MECHANISMS OF MULTIDRUG RESISTANCE AND IMPLICATIONS FOR THERAPY

  1988cited by this paper
• Multiple-drug resistance in human cancer.

  1987cited by this paper
• Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children.

  1981cited by this paper
• Histopathology and prognosis of Wilms tumor Results from the first national wilms' tumor study

  1978cited by this paper
• Undifferentiated sarcoma of the kidney. A tumor of childhood with histopathologic and clinical characteristics distinct from Wilms' tumor

  1978cited by this paper
• Chromosomal imbalance in the Aniridia-Wilms' tumor association: 11p interstitial deletion.

  1978cited by this paper
• A general theory of carcinogenesis.

  1973cited by this paper
• Mutation and cancer: a model for Wilms' tumor of the kidney.

  1972cited by this paper
• Mutation and cancer: statistical study of retinoblastoma.

  1971cited by this paper
• ASSOCIATION OF WILMS'S TUMOR WITH ANIRIDIA, HEMIHYPERTROPHY AND OTHER CONGENITAL MALFORMATIONS.

  1964cited by this paper

• Study of Wilms tumor 1 gene expression in patients with acute leukemia

  2018cites this paper
• Quantitative assessment of Wilms tumor 1 expression by real-time quantitative polymerase chain reaction in patients with acute myeloblastic leukemia

  2017cites this paper
• Differential expression of immunohistochemical markers in primary lung and breast cancers enriched for triple‐negative tumours

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• Ambiguous Genitalia in the Newborn

  2015cites this paper
• WT1 GENE EXPRESSION IN THE PERIPHERAL BLOOD OF PATIENTS SUFFERING FROM HEMATOLOGICAL MALIGNANCIES

  2014cites this paper
• Ambiguous Genitalia in Newborns

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• Is PAX2 a Reliable Marker in Differentiating Diffuse Malignant Mesotheliomas of Peritoneum From Serous Carcinomas of Müllerian Origin?

  2012cites this paper
• Wilms’ tumor protein and FLT3‐internal tandem duplication expression in patients with de novo acute myeloid leukemia

  2011cites this paper
• Dual use of a single Wilms' tumor 1 immunohistochemistry in evaluation of ovarian tumors: a preliminary study of 20 cases

  2010cites this paper
• Primary pleural epithelioid angiosarcoma. A case report and review of the literature.

  2010cites this paper
• Preoperative diagnosis of congenital segmental giant megaureter presenting as a fetal abdominal mass.

  2010cites this paper
• Dual usages of single Wilms' tumor 1 immunohistochemistry in evaluation of breast tumors: A preliminary study of 30 cases

  2009cites this paper
• Integrative genomic analyses on interferon-λs and their roles in cancer prediction

  2009cites this paper
• Aberrant p63 and WT-1 expression in myoepithelial cells of pregnancy-associated breast cancer: implications for tumor aggressiveness and invasiveness

  2009cites this paper
• A WT1 expressing metastatic human kaposi sarcoma xenograft model

  2008cites this paper
• Examination of expression of WT1 gene product and CD44 adhesive molecule in nephroblastoma histologic types.

  2008cites this paper
• The molecular basis of childhood nephrotic syndrome.

  2007cites this paper
• Down-regulation of WT1/+17AA gene expression using RNAi and modulating leukemia cell chemotherapy resistance

  2007cites this paper
• Defining MHC class II T helper epitopes for WT1 tumor antigen

  2006cites this paper
• Ovarian clear cell adenocarcinoma: a continuing enigma

  2006cites this paper
• FGFR1 and WT1 are markers of human prostate cancer progression

  2006cites this paper
• FGFR 1 and WT 1 are markers of human prostate cancer progression

  2006cites this paper
• Gene regulation in spermatogenesis.

  2005cites this paper
• The Spectrum of Pediatric Tumors in Infancy, Childhood, and Adolescence: A Comprehensive Review with Emphasis on Special Techniques in Diagnosis

  2005cites this paper
• WT1 expression in angiogenic tumours of the skin

  2005cites this paper
• Overexpression of ZNRD1 Promotes Multidrug-Resistant Phenotype of Gastric Cancer Cells Through Upregulation of P-Glycoprotein

  2004cites this paper
• Prognostic implications of Wilms' tumor gene (WT1) expression in patients with de novo acute myeloid leukemia.

  2004cites this paper
• Three Subfamilies of KRAB Zinc Finger Proteins : A Structural, Functional and Evolutionary Analysis

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• A novel Krüppel-associated box identified in a panel of mammalian zinc finger proteins

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• Epidemiology of hereditary ocular disorders.

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• Follow-Up of Minimal Residual Disease in Acute Childhood Lymphoblastic Leukemia by WT1 Gene Expression in the Peripheral Blood: The Hungarian Experience

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• cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis.

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• Three Subfamilies of KRAB Zinc Finger Proteins

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• Development of the Ureteric Bud

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  2002influential citation
• The coexpression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia

  2002cites this paper
• Analytical validation of a real-time reverse transcription-polymerase chain reaction quantitation of different transcripts of the Wilms' tumor suppressor gene (WT1).

  2002cites this paper
• Multiple complementary transcripts of pCMa1, a novel gene located at chromosome 11p15.1–2, and melanocytic cell transformation

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