Intestinal permeability study of minoxidil: assessment of minoxidil as a high permeability reference drug for biopharmaceutics classification.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecular Pharmaceutics

• Publication date

  2015-01-05

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/mp500553bPMID 25423288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification.

  2013cited by this paper
• Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine

  2013cited by this paper
• The fraction dose absorbed, in humans, and high jejunal human permeability relationship.

  2012cited by this paper
• Single-pass intestinal perfusion to establish the intestinal permeability of model drugs in mouse.

  2012cited by this paper
• Suitability of isolated rat jejunum model for demonstration of complete absorption in humans for BCS-based biowaiver request.

  2012cited by this paper
• Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice

  2012cited by this paper
• Role of the equilibrative and concentrative nucleoside transporters in the intestinal absorption of the nucleoside drug, ribavirin, in wild-type and Ent1(-/-) mice.

  2012cited by this paper
• Pharmacotherapy review of chronic pediatric hypertension.

  2011cited by this paper
• Drug-permeability and transporter assays in Caco-2 and MDCK cell lines.

  2011cited by this paper
• High-permeability criterion for BCS classification: segmental/pH dependent permeability considerations.

  2010cited by this paper
• In Situ Intestinal Perfusion in Knockout Mice Demonstrates Inhibition of Intestinal P-Glycoprotein by Ritonavir Causing Increased Darunavir Absorption

  2010cited by this paper
• Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat.

  2009cited by this paper
• Fast log P determination by ultra-high-pressure liquid chromatography coupled with UV and mass spectrometry detections

  2009cited by this paper
• Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs.

  2009cited by this paper
• Measurement of dissociation constants (pKa values) of organic compounds by multiplexed capillary electrophoresis using aqueous and cosolvent buffers.

  2008cited by this paper
• Use of the Biopharmaceutical Classification System in Early Drug Development

  2008cited by this paper
• Application of the Biopharmaceutical Classification System in Clinical Drug Development—An Industrial View

  2008cited by this paper
• Classification of Drug Permeability with a Caco-2 Cell Monolayer Assay

  2007cited by this paper
• Biopharmaceutics classification of selected beta-blockers: solubility and permeability class membership.

  2007cited by this paper
• Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model

  2006cited by this paper
• The suitability of an in situ perfusion model for permeability determinations: utility for BCS class I biowaiver requests.

  2006cited by this paper
• The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

  2005cited by this paper
• Correlation Between Oral Drug Absorption in Humans, and Apparent Drug Permeability in TC-7 Cells, A Human Epithelial Intestinal Cell Line: Comparison with the Parental Caco-2 Cell Line

  1998cited by this paper
• A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

  1995cited by this paper
• Pharmacology, pharmacodynamics and pharmacokinetics of sotalol.

  1990cited by this paper
• The Pharmacokinetics of 2.5‐ to 10‐mg Oral Doses of Minoxidil in Healthy Volunteers

  1989cited by this paper
• Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum.

  1985cited by this paper
• Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

  1985cited by this paper
• Pharmacology and Pharmacokinetics of Minoxidil

  1980cited by this paper
• Metabolism of minoxidil, a new hypotensive agent II: biotransformation following oral administration to rats, dogs, and monkeys.

  1975cited by this paper
• Metabolism of minoxidil, a new hypotensive agent I: absorption, distribution, and excretion following administration to rats, dogs, and monkeys.

  1975cited by this paper
• Pharmacokinetic studies on the selectiveβ1-receptor antagonist metoprolol in man

  1974cited by this paper
• Pharmacokinetic studies of minoxidil

  1972cited by this paper

• Exploring Experimental and Statistical Approaches to Control Oversensitivity of In Vitro Permeability to Excipient Effects

  2025cites this paper
• An In Vitro Gut–Liver–Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic–Polycosanol Combination

  2025cites this paper
• Minoxidil/salicylic acid hydrogel formulated for alopecia treatment: Supramolecular interactions modulate physicochemical properties and biological activities revealed by experimental and theoretical studies

  2024cites this paper
• Effects of Compound Probiotics on Pharmacokinetics of Cytochrome 450 Probe Drugs in Rats

  2024cites this paper
• Cellulose nanocrystal-stabilized Pickering emulsion gels as vehicles for follicular delivery of minoxidil.

  2024cites this paper
• Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth

  2024cites this paper
• A Unique In Vitro Assay to Investigate ABCB4 Transport Function

  2023cites this paper
• Caco-2 Cell Line Standardization with Pharmaceutical Requirements and In Vitro Model Suitability for Permeability Assays

  2023influential citation
• Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review

  2023cites this paper
• The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

  2022cites this paper
• Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation

  2021cites this paper
• PHARMACEUTICAL WORLD OF PERMEATION ENHANCERS

  2021cites this paper
• In Silico Prediction of Intestinal Permeability by Hierarchical Support Vector Regression

  2020cites this paper
• Segmental-Dependent Solubility and Permeability as Key Factors Guiding Controlled Release Drug Product Development

  2020cites this paper
• Biopharmaceutics classification evaluation for paris saponin VII.

  2020cites this paper
• Segmental-Dependent Intestinal Drug Permeability: Development and Model Validation of In Silico Predictions Guided by In Vivo Permeability Values.

  2019cites this paper
• Experimental and computational approaches for measuring minoxidil solubility in propylene glycol + water mixtures at different temperatures

  2019cites this paper
• Development and validation of an in vitro human model of drug-induced vascular injury

  2019cites this paper
• Rat intestinal drug permeability: a status report and summary of repeated determinations.

  2019cites this paper
• Solubility of minoxidil in binary mixture of ethanol + water at various temperatures

  2018cites this paper
• Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy.

  2018cites this paper
• Absorption sites of orally administered drugs in the small intestine

  2017cites this paper
• Validación de un modelo in situ de predicción de absorción en colon. Aplicación al desarrollo de formas de liberación controlada.

  2017cites this paper
• Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion.

  2016cites this paper