Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?

We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-α can be administered to inhibit malaria infection. We have also found that if the cytokine F ∗ and a generic drug of efficacy ε are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

• Publication year

  2013

• Venue

  Mathematical biosciences and engineering : MBE

• Publication date

  2013-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3934/mbe.2013.10.609PMID 23906139
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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