Current Approach to Cancer Stem Cells

Kanser Kök Hücreleri (KaKH), normal kök hücreler gibi kendi kendini yenileme ve farklılaşma yeteneğine sahip hücreler olup meme, beyin, akciğer, prostat, testis, over, yemek borusu, kolon, karaciğer gibi birçok dokuda bulunur. Kökenleri henüz keşfedilmemiştir, ancak bu konuda bir dizi hipotez öne sürülmüştür. KaKH tümörün başlangıcından sorumlu ve tümör dokusundaki çok sayıda farklılaşmış hücre topluluğunu oluşturan hücrelerdir. Her bir kanserin kök hücresini tanımlayan biyobelirteçler vardır. KaKH’lerin ve normal kök hücrelerin kendi kendini yenileme ve farklılaşmasında aynı özgü sinyal iletim sistemleri rol oynamaktadır. Fakat KaKH’lerde bu sinyal iletim sistemlerinin düzenlenmesi değişmektedir. KaKH'leri sadece kanserin yaratılmasında değil, evriminde, metastazında ve geç dönemde yeniden ortaya çıkmasında da rol oynamaktadır. MikroRNA'lar, Wnt/β-catenin, Notch ve Hedgehog gibi sinyal yolaklarından oluşan bir düzenleme ağı KaKH özelliklerini kontrol eder. KaKH'leri kanser tedavisinde, konvansiyonel kemoterapi ve radyasyon tedavisine karşı dirençte rol oynarak, kanser metastazının kökeni olarak değerlendirilebilir. KaKH'leri yeni kanser önleyici ilaç keşfi için tedavi protokollerinde hedef haline gelmiştir. Gelecekteki çalışmalar kanserin tedavisi için KaKH’leri hedef alan tedavilerin geliştirilmesine öncülük edecektir.

• Publication year

  2022

• Venue

  Arsiv Kaynak Tarama Dergisi

• Publication date

  2022-06-30

• Fields of study

  Not labeled

• Identifiers
  DOI 10.17827/aktd.1088310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

  2021cited by this paper
• Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

  2021cited by this paper
• Eugenol potentiates cisplatin anti‐cancer activity through inhibition of ALDH‐positive breast cancer stem cells and the NF‐κB signaling pathway

  2018cited by this paper
• Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

  2016cited by this paper
• Identification of CD90 as Putative Cancer Stem Cell Marker and Therapeutic Target in Insulinomas

  2016cited by this paper
• Role of microRNAs in maintaining cancer stem cells.

  2015cited by this paper
• Breast Cancer Stem Cells & Therapy Resistance

  2015cited by this paper
• A Review on the Biology of Cancer Stem Cells

  2014cited by this paper
• Cancer stem cells.

  2012cited by this paper
• Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.

  2012cited by this paper
• Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer‐initiating cells

  2012cited by this paper
• Difluorinated-Curcumin (CDF): A Novel Curcumin Analog is a Potent Inhibitor of Colon Cancer Stem-Like Cells

  2011cited by this paper
• Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up.

  2011cited by this paper
• The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

  2011cited by this paper
• Phenotypic plasticity and epithelial‐mesenchymal transitions in cancer and normal stem cells?

  2011cited by this paper
• Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

  2011cited by this paper
• Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030

  2011cited by this paper
• Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells

  2010cited by this paper
• Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation

  2010cited by this paper
• Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

  2010cited by this paper
• CD90/THY1 is over-expressed in prostate cancer-associated fibroblasts and could serve as a cancer biomarker

  2010cited by this paper
• Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44

  2009cited by this paper
• Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.

  2009cited by this paper
• KLF17 is a negative regulator of epithelial–mesenchymal transition and metastasis in breast cancer

  2009cited by this paper
• EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.

  2009cited by this paper
• Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells

  2009cited by this paper
• Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance

  2009cited by this paper
• DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.

  2009cited by this paper
• Current Status and Issues in Cancer Stem Cell Study

  2008cited by this paper
• Significance of CD90+ cancer stem cells in human liver cancer.

  2008cited by this paper
• CD133+CD44+ Population Efficiently Enriches Colon Cancer Initiating Cells

  2008cited by this paper
• PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.

  2008cited by this paper
• Identification and expansion of human colon-cancer-initiating cells

  2007cited by this paper
• Identification and characterization of tumorigenic liver cancer stem/progenitor cells.

  2007cited by this paper
• Beyond tumorigenesis: cancer stem cells in metastasis

  2007cited by this paper
• Phenotypic characterization of human colorectal cancer stem cells

  2007cited by this paper
• Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

  2007cited by this paper
• Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

  2007cited by this paper
• ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

  2007cited by this paper
• Models, mechanisms and clinical evidence for cancer dormancy

  2007cited by this paper
• The genetics of human longevity.

  2004cited by this paper
• Self-renewal and solid tumor stem cells

  2004cited by this paper
• Identification of human brain tumour initiating cells

  2004cited by this paper
• Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

  2004cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• Prospective identification of tumorigenic breast cancer cells

  2003cited by this paper
• WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

  2000cited by this paper

• No citing papers are available for this paper.