Recent advancements in synthetic biology: current status and challenges.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Gene

• Publication date

  2014-02-01

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1016/j.gene.2013.11.025PMID 24269673
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A new frontier in synthetic biology: automated design of small RNA devices in bacteria.

  2013cited by this paper
• Supplementary Material to: Biological signal processing with a genetic toggle switch

  2013cited by this paper
• Synthetic biology: advancing the design of diverse genetic systems.

  2013cited by this paper
• Synthetic circuits integrating logic and memory in living cells

  2013cited by this paper
• Amplifying Genetic Logic Gates

  2013cited by this paper
• Genetic programs constructed from layered logic gates in single cells

  2012cited by this paper
• Programmable single-cell mammalian biocomputers

  2012cited by this paper
• De novo automated design of small RNA circuits for engineering synthetic riboregulation in living cells

  2012cited by this paper
• Ribozyme-based insulator parts buffer synthetic circuits from genetic context

  2012cited by this paper
• Entrainment of a Population of Synthetic Genetic Oscillators

  2011cited by this paper
• Empirical model and in vivo characterization of the bacterial response to synthetic gene expression show that ribosome allocation limits growth rate.

  2011cited by this paper
• Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’

  2011cited by this paper
• A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

  2011cited by this paper
• A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms.

  2011cited by this paper
• Engineering the logical properties of a genetic AND gate.

  2011cited by this paper
• Automatic Design of Digital Synthetic Gene Circuits

  2011cited by this paper
• Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology

  2011cited by this paper
• Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

  2011cited by this paper
• AraC protein, regulation of the l-arabinose operon in Escherichia coli, and the light switch mechanism of AraC action.

  2010cited by this paper
• A tunable dual-promoter integrator for targeting of cancer cells

  2010cited by this paper
• Transcriptional switching in Escherichia coli during stress and starvation by modulation of sigma activity.

  2010cited by this paper
• Develop reusable and combinable designs for transcriptional logic gates

  2010cited by this paper
• A modular positive feedback-based gene amplifier

  2010cited by this paper
• Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

  2010cited by this paper
• Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

  2010cited by this paper
• A comparative analysis of synthetic genetic oscillators

  2010cited by this paper
• Allostery in the LacI/GalR family: variations on a theme.

  2009cited by this paper
• Termination structures in the Escherichia coli chromosome replication fork trap.

  2009cited by this paper
• A synchronized quorum of genetic clocks

  2009cited by this paper
• Synthetic protein scaffolds provide modular control over metabolic flux

  2009cited by this paper
• Building biological memory by linking positive feedback loops

  2009cited by this paper
• Synthetic Gene Networks That Count

  2009cited by this paper
• Automated Design of Synthetic Ribosome Binding Sites to Precisely Control Protein Expression

  2009cited by this paper
• Refinement and standardization of synthetic biological parts and devices

  2008cited by this paper
• Intron length increases oscillatory periods of gene expression in animal cells.

  2008cited by this paper
• A fast, robust, and tunable synthetic gene oscillator

  2008cited by this paper
• Design and Construction of a Double Inversion Recombination Switch for Heritable Sequential Genetic Memory

  2008cited by this paper
• Combinatorial transcriptional control of the lactose operon of Escherichia coli

  2007cited by this paper
• Noise and kinetics of LuxR positive feedback loops.

  2007cited by this paper
• Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

  2006cited by this paper
• Regulatory dynamics of synthetic gene networks with positive feedback.

  2006cited by this paper
• rRNA promoter regulation by nonoptimal binding of sigma region 1.2: an additional recognition element for RNA polymerase.

  2006cited by this paper
• Riboswitches as antibacterial drug targets

  2006cited by this paper
• Foundations for engineering biology

  2005cited by this paper
• The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors.

  2005cited by this paper
• Programmable ligand-controlled riboregulators of eukaryotic gene expression

  2005cited by this paper
• Tuning genetic control through promoter engineering.

  2005cited by this paper
• Riboswitches as versatile gene control elements.

  2005cited by this paper
• A synthetic multicellular system for programmed pattern formation

  2005cited by this paper
• The lac repressor.

  2005cited by this paper
• The regulation of bacterial transcription initiation

  2004cited by this paper
• Engineered riboregulators enable post-transcriptional control of gene expression

  2004cited by this paper
• Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms

  2003cited by this paper
• Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading.

  2003cited by this paper
• Reprogramming Control of an Allosteric Signaling Switch Through Modular Recombination

  2003cited by this paper
• Multiple sigma subunits and the partitioning of bacterial transcription space.

  2003cited by this paper
• Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli.

  2003cited by this paper
• Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression

  2002cited by this paper
• Combinatorial Synthesis of Genetic Networks

  2002cited by this paper
• Homogeneous expression of the P(BAD) promoter in Escherichia coli by constitutive expression of the low-affinity high-capacity AraE transporter.

  2001cited by this paper
• Regulation of the L-arabinose operon of Escherichia coli.

  2000cited by this paper
• A synthetic oscillatory network of transcriptional regulators

  2000cited by this paper
• Construction of a genetic toggle switch in Escherichia coli

  2000cited by this paper
• Activities of constitutive promoters in Escherichia coli.

  1999cited by this paper
• New Unstable Variants of Green Fluorescent Protein for Studies of Transient Gene Expression in Bacteria

  1998cited by this paper
• Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential.

  1997cited by this paper
• Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements.

  1997cited by this paper
• Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

  1996cited by this paper
• The role of general initiation factors in transcription by RNA polymerase II.

  1996cited by this paper
• Proximity probing of Tet repressor to tet operator by dimethylsulfate reveals protected and accessible functions for each recognized base-pair in the major groove.

  1995cited by this paper
• Promoter structure, promoter recognition, and transcription activation in prokaryotes.

  1994cited by this paper
• Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.

  1994cited by this paper
• A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase.

  1993cited by this paper
• The three operators of the lac operon cooperate in repression.

  1990cited by this paper
• Recognition of nucleotide sequences at the Escherichia coli galactose operon P1 promoter by RNA polymerase.

  1989cited by this paper
• Regulation of the Escherichia coli L-arabinose operon studied by gel electrophoresis DNA binding assay.

  1984cited by this paper
• Compilation and analysis of Escherichia coli promoter DNA sequences.

  1983cited by this paper
• Mechanism of araC autoregulation and the domains of two overlapping promoters, Pc and PBAD, in the L-arabinose regulatory region of Escherichia coli.

  1981cited by this paper
• Determinant of cistron specificity in bacterial ribosomes

  1975cited by this paper
• Genetic regulatory mechanisms in the synthesis of proteins.

  1961cited by this paper

• Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases.

  2025cites this paper
• Bioremediation Techniques: Harnessing the Power of Microorganisms for Environmental Restoration

  2023cites this paper
• Synthetic biology-inspired cell engineering in diagnosis, treatment and drug development

  2023cites this paper
• Protein Splicing of Inteins: A Powerful Tool in Synthetic Biology

  2022cites this paper
• CRISPR-assisted strategies for futuristic phytoremediation

  2022cites this paper
• Designing synthetic transcription factors: A structural perspective.

  2022cites this paper
• Introductory Chapter: From BioBricks to Synthetic Genomes

  2022cites this paper
• Understanding and application of Bacillus nitrogen regulation: A synthetic biology perspective

  2022cites this paper
• Systematic engineering of Bacillus amyloliquefaciens for efficient production of poly-γ-glutamic acid from crude glycerol.

  2022cites this paper
• Streptomyces alkaliterrae sp . nov . , isolated from an alkaline soil , and emended 1 descriptions of Streptomyces alkaliphilus , Streptomyces calidiresistens and Streptomyces 2 durbertensis 3

  2021cites this paper
• An introduction to microbial cell factories for production of biomolecules

  2021cites this paper
• Genetic engineering approaches for detecting environmental pollutants

  2020cites this paper
• Recent Advances, Challenges, and Opportunities in Synthetic Genomes

  2020cites this paper
• CRISPR technology for genome editing

  2020cites this paper
• Genome Mining as New Challenge in Natural Products Discovery

  2020cites this paper
• Gene regulation across scales – how biophysical constraints shape evolution

  2020cites this paper
• System metabolic engineering strategies for cell factories construction

  2020cites this paper
• Synthetic biology approaches for bioremediation

  2020cites this paper
• An Introduction to Design of Microbial Strain using Synthetic Biology Toolboxes for Production of Biomolecules

  2020cites this paper
• Streptomyces alkaliterrae sp. nov., isolated from an alkaline soil, and emended descriptions of Streptomyces alkaliphilus, Streptomyces calidiresistens and Streptomyces durbertensis.

  2020cites this paper
• Repudiating the Fourth Industrial Revolution Discourse: A New Episteme of Technological Progress

  2020cites this paper
• Chapter 2 Gene Expression Engineering

  2019cites this paper
• Engineering Escherichia coli for autoinducible production of L-valine: An example of an artificial positive feedback loop in amino acid biosynthesis

  2019cites this paper
• Challenges and Opportunities at the Interface of Synthetic Biology, Microbiology, and Intellectual Property Rights

  2019cites this paper
• Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems

  2019cites this paper
• Exploring the Potential and Opportunities of Current Tools for Removal of Hazardous Materials From Environments

  2019cites this paper
• Recent Advances, Challenges, and Opportunities in Bioremediation of Hazardous Materials

  2019cites this paper
• Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology

  2019cites this paper
• Engineering Strategies in Microorganisms for the Enhanced Production of Squalene: Advances, Challenges and Opportunities

  2019cites this paper
• Exploring the Potential of Cell-Free Protein Synthesis for Extending the Abilities of Biological Systems

  2019cites this paper
• Microbial Production of Flavonoids: Engineering Strategies for Improved Production

  2019cites this paper
• Calibrating Transcriptional Activity Using Constitutive Synthetic Promoters in Mutants for Global Regulators in Escherichia coli

  2018cites this paper
• Synthetic small RNAs: Current status, challenges, and opportunities

  2018cites this paper
• Images of synthetic life: Mapping the use and function of metaphors in the public discourse on synthetic biology

  2018cites this paper
• New insight into the control of peptic ulcer by targeting the histamine H2 receptor

  2018cites this paper
• Advances and Tools in Engineering Yeast for Pharmaceutical Production

  2018cites this paper
• Riboswitch-Based Reversible Dual Color Sensor.

  2017cites this paper
• Stabil och antibiotikafri läkemedelsproduktion i rekombinant Escherichia coli

  2017cites this paper
• Synthetic biology as an emerging science for biotechnological applications

  2017cites this paper
• Enhanced heterologous protein productivity by genome reduction in Lactococcus lactis NZ9000

  2017cites this paper
• Exploring the potential of genome editing CRISPR-Cas9 technology.

  2017cites this paper
• The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast

  2017cites this paper
• Book Review: Systems and Synthetic Biology

  2017cites this paper
• Control of synthetic gene networks and its applications

  2017cites this paper
• Gene Expression Engineering

  2016cites this paper
• Dual control system – A novel scaffolding architecture of an inducible regulatory device for the precise regulation of gene expression

  2016cites this paper
• Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories

  2016cites this paper
• Rlm1 mediates positive autoregulatory transcriptional feedback that is essential for Slt2-dependent gene expression

  2016cites this paper
• Synthetic Biology of Natural Products.

  2016cites this paper
• Role of Microbes in Food and Industrial Microbiology

  2016cites this paper
• Error control in bacterial quorum communications

  2016cites this paper
• Biodegradable Three-Layered Micelles and Injectable Hydrogels.

  2016cites this paper
• Synthetic Biology Standards and Methods of DNA Assembly

  2016cites this paper
• Declaration of Authorship

  2016cites this paper
• Recent advances in synthetic biology

  2015cites this paper
• Exploring the Potential of Small Regulatory RNA towards Microbial Engineering

  2015cites this paper
• Improvement of a photoautotrophic chassis robustness for Synthetic Biology applications

  2015cites this paper
• Prosthetic gene networks as an alternative to standard pharmacotherapies for metabolic disorders.

  2015cites this paper
• Recent advances and versatility of MAGE towards industrial applications

  2015cites this paper
• The synthetic biology puzzle: a qualitative study on public reflections towards a governance framework

  2015cites this paper
• Engineering Synthetic cis-Regulatory Elements for Simultaneous Recognition of Three Transcriptional Factors in Bacteria.

  2015cites this paper
• Biotechnologie von Morgen: metabolisch optimierte Zellen für die bio‐basierte Produktion von Chemikalien und Treibstoffen, Materialien und Gesundheitsprodukten

  2015cites this paper
• Synthetic biology for pharmaceutical drug discovery

  2015cites this paper
• Functional living biointerfaces to direct cell-material interaction

  2015cites this paper
• Synthetic biology advances for pharmaceutical production

  2015cites this paper
• Nuclear quantum tunnelling in enzymatic reactions--an enzymologist's perspective.

  2015cites this paper
• Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products.

  2015cites this paper
• Genome reduction boosts heterologous gene expression in Pseudomonas putida

  2015cites this paper
• The development and characterization of synthetic minimal yeast promoters

  2015cites this paper
• Translational Research: From Biological Discovery to Public Benefit (or Not)

  2014cites this paper
• Yeast synthetic biology for high-value metabolites.

  2014cites this paper
• Production of D-xylonate and organic acid tolerance in yeast

  2014cites this paper
• Recent advances and opportunities in synthetic logic gates engineering in living cells

  2014cites this paper