Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Developmental Biology

• Publication date

  2007-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.YDBIO.2007.01.013PMID 17300776PMCID PMC1950278
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inactivation of NADPH oxidase organizer 1 results in severe imbalance.

  2006cited by this paper
• Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish.

  2006cited by this paper
• The synaptic vesicle: cycle of exocytosis and endocytosis.

  2006cited by this paper
• Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development.

  2006cited by this paper
• The role of extracellular calcium in exo- and endocytosis of synaptic vesicles at the frog motor nerve terminals.

  2006cited by this paper
• Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae.

  2005influential reference
• Na+ influx triggers bleb formation on inner hair cells.

  2005cited by this paper
• Interactions of the Extracellular Matrix Proteoglycans Decorin and Biglycan with C1q and Collectins1

  2005cited by this paper
• Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition Published, JLR Papers in Press, December 1, 2004. DOI 10.1194/jlr.M400253-JLR200

  2005cited by this paper
• Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.

  2004cited by this paper
• Gravity receptor function in mice with graded otoconial deficiencies.

  2004cited by this paper
• Mutated otopetrin 1 affects the genesis of otoliths and the localization of Starmaker in zebrafish

  2004cited by this paper
• Immunohistochemical localization of two otolith matrix proteins in the otolith and inner ear of the rainbow trout, Oncorhynchus mykiss: comparative aspects between the adult inner ear and embryonic otocysts

  2004influential reference
• Does theory inform practice in health promotion in Australia?

  2004cited by this paper
• Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice.

  2004cited by this paper
• Benign paroxysmal positional vertigo: diagnosis and treatment.

  2004cited by this paper
• Development of the utricular macula in the mouse

  2004cited by this paper
• Control of Crystal Size and Lattice Formation by Starmaker in Otolith Biomineralization

  2003cited by this paper
• A mathematical model for top-shelf vertigo: the role of sedimenting otoconia in BPPV.

  2003cited by this paper
• Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.

  2003cited by this paper
• First steps of otolith formation of the zebrafish: role of glycogen?

  2002cited by this paper
• Fish otolith contains a unique structural protein, otolin-1.

  2002influential reference
• Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome.

  2001cited by this paper
• Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion

  2001influential reference
• The otoconia of the guinea pig utricle: internal structure, surface exposure, and interactions with the filament matrix.

  2000cited by this paper
• Targeted disruption of Otog results in deafness and severe imbalance

  2000cited by this paper
• Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals.

  1999influential reference
• Phospholipase A2 Modification of Low Density Lipoproteins Forms Small High Density Particles with Increased Affinity for Proteoglycans and Glycosaminoglycans*

  1999cited by this paper
• Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15.

  1999cited by this paper
• Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL/6JEi-het mice.

  1999cited by this paper
• Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes.

  1998cited by this paper
• Phenotypic and biochemical consequences of collagen X mutations in mice and humans.

  1998cited by this paper
• Balance and Hearing Deficits in Mice with a Null Mutation in the Gene Encoding Plasma Membrane Ca2+-ATPase Isoform 2*

  1998cited by this paper
• Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2.

  1998influential reference
• Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner ear.

  1997influential reference
• Identification of a structural constituent and one possible site of postembryonic formation of a teleost otolithic membrane.

  1997cited by this paper
• Molecular biology of matrix vesicles.

  1995influential reference
• Biological characteristics of the globular substance in the otoconial membrane of the guinea pig.

  1995influential reference
• The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix.

  1995cited by this paper
• Visualization of newt aragonitic otoconial matrices using transmission electron microscopy.

  1995cited by this paper
• Localization of osteopontin in the otoconial organs of adult rats.

  1994cited by this paper
• Histochemical detection of glycogen and glycoconjugates in the inner ear with modified concanavalin A-horseradish peroxidase procedures

  1994cited by this paper
• Otoconin-22, the major protein of aragonitic frog otoconia, is a homolog of phospholipase A2.

  1993influential reference
• Localization of pyroantimonate-precipitable calcium in the vestibular organs of the rat and guinea pig.

  1991influential reference
• Glycoconjugates in the otolithic organ of the developing chick embryo.

  1991cited by this paper
• A contribution with review to the description of mineralization of bone and other calcified tissues in vivo

  1991cited by this paper
• Macromolecular organization of chicken type X collagen in vitro

  1991cited by this paper
• Each otoconia polymorph has a protein unique to that polymorph.

  1991cited by this paper
• Immunohistochemistry and histochemistry of the inner ear gelatinous membranes and statoconia of the chick (Gallus domesticus).

  1990cited by this paper
• Characterization of the collagen in the hexagonal lattice of Descemet's membrane: its relation to type VIII collagen

  1990cited by this paper
• Aberrant elemental composition of otoconia in the dancer mouse mutant with a semidominant gene causing a morphogenetic type of inner ear defect.

  1988cited by this paper
• The behavior and vestibular nuclear morphology of otoconia-deficient pallid mutant mice.

  1983cited by this paper
• Pathology of neuroepithelial suprastructures of the human inner ear.

  1982cited by this paper
• Hereditary deafness with hydrops and anomalous calcium phosphate deposits.

  1981cited by this paper
• Crystal structure refinements of magnesite, calcite, rhodochrosite, siderite, smithonite, and dolomite, with discussion of some aspects of the stereochemistry of calcite type carbonates

  1981cited by this paper
• Development of otoconia.

  1980influential reference
• An electron microscope study of crystal calcium carbonate formation in the mouse otolith

  1979cited by this paper
• Formation area of the statoconia.

  1979cited by this paper
• A CRYSTALLOGRAPHIC STUDY OF VERTEBRATE OTOLITHS

  1963cited by this paper
• Macrophage-specific overexpression of group IIa sPLA 2 increases atherosclerosis and enhances collagen deposition

  year unknowncited by this paper

• Characterization of inner ear granular bodies by polarization-resolved second harmonic generation microscopy

  2026cites this paper
• Vestibular Otolithic Receptors: Association Between Molecular Mechanism of Degeneration and Benign Paroxysmal Positional Vertigo

  2025cites this paper
• Parental exposure to CdSe/ZnS QDs affects otolith development and locomotor behavior in rare minnow (Gobiocypris rarus) offspring.

  2025cites this paper
• SpacGPA: annotating spatial transcriptomes through de novo interpretable gene programs

  2025cites this paper
• A New Perspective to Interpret How the Vestibular Efferent System Correlates the Complexity of Routine Balance Maintenance with Management of Emergency Fall Prevention Strategies

  2024cites this paper
• NADPH Oxidase 3: Beyond the Inner Ear

  2024cites this paper
• Serum Otoconin-90 and Otolin-1 Concentrations in Benign Paroxysmal Positional Vertigo

  2024cites this paper
• Otolin-1 as a biomarker for the evaluation of the effectiveness of betahistine treatment for benign paroxysmal positional vertigo

  2023cites this paper
• Structure and Physiology of Human Ear Involved in Hearing

  2023cites this paper
• Vestibular Deficits in Deafness: Clinical Presentation, Animal Modeling, and Treatment Solutions

  2022cites this paper
• Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear

  2022cites this paper
• Advances in otolith-related protein research

  2022cites this paper
• Vitamin D Supplementation for Benign Paroxysmal Positional Vertigo: A Systematic Review

  2022cites this paper
• N'-terminal- and Ca2+-induced stabilization of high-order oligomers of full-length Danio rerio and Homo sapiens otolin-1.

  2022cites this paper
• Vitamin D Insufficiency/Deficiency in Patients with Recurrent Benign Paroxysmal Positional Vertigo

  2022cites this paper
• Second harmonic generation microscopy of otoconia.

  2022cites this paper
• Functional cooperation between two otoconial proteins Oc90 and Nox3

  2021influential citation
• Development and evolution of the vestibular apparatuses of the inner ear

  2021cites this paper
• Morphological Effect of Vitamin D Deficiency on Globular Substances in Mice

  2021cites this paper
• Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels.

  2021cites this paper
• Proceedings of the 2020 Classic Examples in Toxicologic Pathology XXVII

  2021cites this paper
• Natural Mutations Affect Structure and Function of gC1q Domain of Otolin-1

  2021cites this paper
• Relation between vitamin D deficiency and benign paroxysmal positional vertigo

  2021cites this paper
• Molecular Mediators of Estrogen Reduction-induced Otolith Shedding

  2021cites this paper
• Otoconia Structure After Short- and Long-Duration Exposure to Altered Gravity

  2021cites this paper
• A mouse model for benign paroxysmal positional vertigo with genetic predisposition for displaced otoconia

  2020cites this paper
• Molecular Basis of Vestibular Organ Formation During Ontogeny

  2020cites this paper
• Evaluation of the structure of the otoconial layer using micro-computed tomography.

  2020cites this paper
• Functional derivatives of human dentin matrix protein 1 modulate morphology of calcium carbonate crystals

  2020cites this paper
• Nanostructure of mouse otoconia.

  2020cites this paper
• Roles of secreted phospholipase A2 group IIA in inflammation and host defense.

  2019cites this paper
• Zebrafish Otolith Biomineralization Requires Polyketide Synthase

  2019cites this paper
• Inner Ear Proteins as Potential Biomarkers.

  2019cites this paper
• Otolith Biochemistry—A Review

  2019cites this paper
• Otopetrin-2 Immunolocalization in the Human Macula Utricle

  2019cites this paper
• Expression and function of lncRNA MALAT-1 in the embryonic development of zebrafish.

  2019cites this paper
• Otopetrin-2 Immunolocalization in the Human Macula Utricle

  2019cites this paper
• Mechanism Underlying the Effects of Estrogen Deficiency on Otoconia

  2018cites this paper
• Zebrafish Otolith Biomineralization Requires Polyketide Synthase

  2018cites this paper
• Estradiol deficiency is a risk factor for idiopathic benign paroxysmal positional vertigo in postmenopausal female patients

  2018cites this paper
• Formation of the inner ear during embryonic and larval development of the cichlid fish (Oreochromis mossambicus)

  2017cites this paper
• DECIPHERING THE INDUCTION AND PATTERNING OF THE CONJUNCTIVAL PAPILLAE IN THE CHICKEN, GALLUS GALLUS

  2017cites this paper
• Effect of calcium ions on structure and stability of the C1q‐like domain of otolin‐1 from human and zebrafish

  2017cites this paper
• Spatiotemporal differences in otoconial gene expression

  2016influential citation
• Not All Inner Ears are the Same: Otolith Matrix Proteins in the Inner Ear of Sub‐Adult Cichlid Fish, Oreochromis Mossambicus, Reveal Insights Into the Biomineralization Process

  2016influential citation
• The zebrafish homologs of SET/I2PP2A oncoprotein: expression patterns and insights into their physiological roles during development.

  2016cites this paper
• Spatial Expression of Otolith Matrix Protein‐1 and Otolin‐1 in Normally and Kinetotically Swimming Fish

  2015cites this paper
• Mineralization in Health and Mechanism of Kidney Stone Formation

  2015cites this paper
• Identification and characterization of mouse otic sensory lineage genes

  2015cites this paper
• Mechanisms of otoconia and otolith development

  2015influential citation
• Biological Materials of Marine Origin

  2015cites this paper
• Vestibular dysfunction, altered macular structure and trait localization in A/J inbred mice

  2015cites this paper
• A new era of secreted phospholipase A2

  2015cites this paper
• Biocomposites and Mineralized Tissues

  2015cites this paper
• Genetics of peripheral vestibular dysfunction: lessons from mutant mouse strains.

  2014cites this paper
• In Vitro Calcite Crystal Morphology Is Modulated by Otoconial Proteins Otolin-1 and Otoconin-90

  2014cites this paper
• Principles of Calcite Dissolution in Human and Artificial Otoconia

  2014cites this paper
• Effect of Otoconial Proteins Fetuin A, Osteopontin, and Otoconin 90 on the Nucleation and Growth of Calcite

  2014cites this paper
• The vestibuloocular reflex of tadpoles (Xenopus laevis) after knock-down of the isthmus-related transcription factor XTcf-4

  2013cites this paper
• Vitamin D deficiency and benign paroxysmal positioning vertigo.

  2013cites this paper
• Otolithic Membrane Damage in Patients With Endolymphatic Hydrops and Drop Attacks

  2012cites this paper
• Proteins Involved in Otoconia Formation and Maintenance

  2012cites this paper
• Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of otoconia, and pathogenesis of benign positional vertigo.

  2012influential citation
• Bone and the Ear

  2012cites this paper
• Crystal Growth of Calcium Carbonate in Hydrogels as a Model of Biomineralization

  2012cites this paper
• Secreted phospholipase A2 revisited.

  2011cites this paper
• Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

  2011cites this paper
• Cell Type–Specific Transcriptome Analysis Reveals a Major Role for Zeb1 and miR-200b in Mouse Inner Ear Morphogenesis

  2011influential citation
• Significance of tertiary conformation of otoconial matrix proteins – clinical implications

  2011cites this paper
• Matrix Recruitment and Calcium Sequestration for Spatial Specific Otoconia Development

  2011influential citation
• Mammalian Otolin: A Multimeric Glycoprotein Specific to the Inner Ear that Interacts with Otoconial Matrix Protein Otoconin-90 and Cerebellin-1

  2010influential citation
• Autophagy is essential for mouse sense of balance.

  2010cites this paper
• In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure.

  2010influential citation
• Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.

  2010cites this paper
• Expression, functional, and structural analysis of proteins critical for otoconia development

  2010cites this paper
• Calcium Oxalate Stone Formation in the Inner Ear as a Result of an Slc26a4 Mutation*♦

  2010cites this paper
• Biomineralization in humans: making the hard choices in life.

  2009cites this paper
• MOLECULAR DETERMINATION OF NOVEL GENES AND PATHWAYS REQUIRED FOR VESTIBULAR MORPHOGENESIS IN ZEBRAFISH

  2008cites this paper
• Otoconin-90 deletion leads to imbalance but normal hearing: a comparison with other otoconia mutants.

  2008influential citation
• Otoc1: A novel otoconin‐90 ortholog required for otolith mineralization in zebrafish

  2008cites this paper
• Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development

  2008cites this paper
• Osteopontin is not Critical for Otoconia Formation or Balance Function

  2008cites this paper
• Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice.

  2008cites this paper
• Sparc Protein Is Required for Normal Growth of Zebrafish Otoliths

  2008cites this paper
• Shaping the mammalian auditory sensory organ by the planar cell polarity pathway.

  2007cites this paper