Effect of Excessive Serotonin on Pharmacokinetics of Cephalexin after Oral Administration: Studies with Serotonin-Excessive Model Rats

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Pharmaceutical Research

• Publication date

  2022-07-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s11095-022-03325-8PMID 35799082
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Re-writing Oral Pharmacokinetics Using Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models

  2022influential reference
• Possible regulation of P-glycoprotein function by adrenergic agonists in a vascular-luminal perfused preparation of small intestine.

  2021cited by this paper
• The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the Epithelium

  2019cited by this paper
• Potentiated serotonin signaling in serotonin re‐uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function

  2019cited by this paper
• Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD

  2019influential reference
• Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine.

  2019cited by this paper
• 5-HT1F receptor regulates mitochondrial homeostasis and its loss potentiates acute kidney injury and impairs renal recovery.

  2018cited by this paper
• Non-conventional features of peripheral serotonin signalling — the gut and beyond

  2017cited by this paper
• Development of the intrinsic and extrinsic innervation of the gut.

  2016influential reference
• Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine

  2016cited by this paper
• The role of serotonin and its receptors in activation of immune responses and inflammation

  2015cited by this paper
• 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract

  2013cited by this paper
• A 5-hydroxytryptamine receptor antagonist, sarpogrelate, reduces renal tubulointerstitial fibrosis by suppressing PAI-1.

  2013cited by this paper
• Differential signal pathway activation and 5-HT function: the role of gut enterochromaffin cells as oxygen sensors.

  2012cited by this paper
• Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

  2011cited by this paper
• Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.

  2011cited by this paper
• Expression of 5-HT1A and 5-HT7 receptors in Caco-2 cells and their role in the regulation of serotonin transporter activity.

  2009cited by this paper
• An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine

  2009influential reference
• Transcriptional regulation of the human Na+/H+ exchanger NHE3 by serotonin in intestinal epithelial cells.

  2009cited by this paper
• Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells.

  2009cited by this paper
• Quantitative Evaluation of PEPT1 Contribution to Oral Absorption of Cephalexin in Rats

  2008influential reference
• Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug.

  2008cited by this paper
• Serotonin and GI clinical disorders.

  2008cited by this paper
• Pharmaceutical and pharmacological importance of peptide transporters

  2008cited by this paper
• Enteric nervous system abnormalities in inflammatory bowel diseases

  2008cited by this paper
• Serotonin pharmacology in the gastrointestinal tract: a review

  2008cited by this paper
• Quantitative prediction of oral absorption of PEPT1 substrates based on in vitro uptake into Caco-2 cells.

  2008cited by this paper
• Function, expression, and characterization of the serotonin transporter in the native human intestine.

  2008cited by this paper
• Augmented brain 5‐HT crosses the blood–brain barrier through the 5‐HT transporter in rat

  2008cited by this paper
• 5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4 receptors in conscious mice.

  2007cited by this paper
• Gene expression and regulation of drug transporters in the intestine and kidney.

  2007cited by this paper
• Novel therapeutic targets for enteric nervous system disorders.

  2007cited by this paper
• Serotonin catabolism in the central and enteric nervous systems of rats upon induction of serotonin syndrome

  2007cited by this paper
• Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure

  2006cited by this paper
• Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome.

  2006cited by this paper
• Serotonin inhibits Na+/H+ exchange activity via 5-HT4 receptors and activation of PKC alpha in human intestinal epithelial cells.

  2005cited by this paper
• Up-Regulation of P-Glycoprotein Expression in Small Intestine under Chronic Serotonin-Depleted Conditions in Rats

  2005cited by this paper
• The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats.

  2004cited by this paper
• 5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca2+-dependent signaling pathways and 5-HT4 receptors in mice.

  2004cited by this paper
• Regulation of drug absorption from small intestine by enteric nervous system I: a poorly absorbable drug via passive diffusion.

  2004cited by this paper
• Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome.

  2004cited by this paper
• Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

  2003cited by this paper
• Cholinergic inhibition of electrogenic sodium absorption in the guinea pig distal colon.

  2003cited by this paper
• Altered Diurnal Rhythm of Intestinal Peptide Transporter by Fasting and Its Effects on the Pharmacokinetics of Ceftibuten

  2003cited by this paper
• Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways.

  2003cited by this paper
• Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells.

  2002cited by this paper
• Diurnal rhythm of H+-peptide cotransporter in rat small intestine.

  2002cited by this paper
• Active bicarbonate-dependent secretion evoked by 5-hydroxytryptamine in porcine ileal mucosa is mediated by opioid-sensitive enteric neurons.

  2002cited by this paper
• Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers.

  2002cited by this paper
• Analysis and prediction of absorption behavior for theophylline orally administered as powders based on gastrointestinal-transit-absorption (Gita) model.

  2002influential reference
• Model of rapid gastrointestinal transit in dogs: effects of muscarinic antagonists and a nitric oxide synthase inhibitor

  2002cited by this paper
• Serotonergic modulating drugs for functional gastrointestinal diseases.

  2002influential reference
• Progress in understanding the structure-activity relationships of P-glycoprotein.

  2002cited by this paper
• Enteric nerve stimulation evokes a premature colonic migrating motor complex in mouse

  2002cited by this paper
• Evaluation of absorption kinetics of orally administered theophylline in rats based on gastrointestinal transit monitoring by gamma scintigraphy.

  2001cited by this paper
• COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum.

  2001cited by this paper
• Risperidone counteracts lethality in an animal model of the serotonin syndrome

  2000cited by this paper
• Impaired synthesis or cellular storage of norepinephrine, dopamine and 5-hydroxytryptamine in inflammatory bowel disease

  2000cited by this paper
• Neural control of intestinal ion transport and paracellular permeability is altered by nutritional status.

  2000cited by this paper
• a 2-Adrenergic Receptors Stimulate Oligopeptide Transport in a Human Intestinal Cell Line 1

  2000cited by this paper
• Membrane transporters.

  2000influential reference
• Types of neurons in the enteric nervous system.

  2000cited by this paper
• The enteric nervous system and regulation of intestinal motility.

  1999cited by this paper
• Gastrointestinal transit of pellets in rats: effect of size and density.

  1999cited by this paper
• Regulation of the high‐affinity H+/peptide cotransporter in renal LLC‐PK1 cells

  1999influential reference
• Segment-specific effects of epinephrine on ion transport in the colon of the rat.

  1998cited by this paper
• Ionizing radiation stimulates muscarinic regulation of rat intestinal mucosal function.

  1998cited by this paper
• Ionizing radiation stimulates muscarinic regulation of rat intestinal mucosal function.

  1998cited by this paper
• Segment-specific effects of epinephrine on ion transport in the colon of the rat.

  1998cited by this paper
• Absorption behavior of orally administered drugs in rats treated with propantheline.

  1998cited by this paper
• Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation.

  1997cited by this paper
• An isocratic assay for norepinephrine, dopamine, and 5-hydroxytryptamine using their native fluorescence by high-performance liquid chromatography with fluorescence detection in discrete brain areas of rat.

  1997cited by this paper
• Prediction of the Plasma Concentration Profiles of Orally Administered Drugs in Rats on the Basis of Gastrointestinal Transit Kinetics and Absorbability

  1997cited by this paper
• 5-Hydroxytryptamine, angiotensin and bradykinin transiently increase intracellular calcium concentrations and PKC-alpha activity, but do not induce mitogenesis in human vascular smooth muscle cells.

  1997influential reference
• Indirect gastrointestinal transit monitoring and absorption of theophylline

  1996cited by this paper
• Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo.

  1993cited by this paper
• Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended-Release (ER) Tablets

  1993cited by this paper
• Intestinal motility changes in rats after enteric serotonergic neuron destruction.

  1991cited by this paper
• The influence of density on the gastrointestinal transit of pellets

  1990cited by this paper
• Transit of pharmaceutical dosage forms through the small intestine.

  1986cited by this paper
• Relation between antral motility and gastric emptying of solids and liquids in humans.

  1985cited by this paper
• A pharmacokinetic analysis program (multi) for microcomputer.

  1981cited by this paper
• A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline transport systems.

  1978cited by this paper
• Canine gastric emptying of solids and liquids.

  1977cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970influential reference
• The isolation of a brush border membrane fraction from rat kidney.

  1970cited by this paper
• The Motility of the Small Intestine

  1961cited by this paper

• Establishment of a novel in vitro co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs.

  2023cites this paper
• Mechanisms of Nanoparticle Transport across Intestinal Tissue: An Oral Delivery Perspective.

  2023cites this paper
• Possible Regulation of P-glycoprotein Function by Adrenergic Agonists II: Study with isolated rat jejunal sheets and Caco-2 cell monolayers.

  2023cites this paper