Direct T-cell Presentation by cDC1: The Key Feature for Cancer Vaccine Success?

Margaux Hubert,C. Caux,J. Valladeau-Guilemond

Published 2022 in Cancer immunology research

ABSTRACT

In this issue of Cancer Immunology Research, Ferris and colleagues demonstrate that type 1 conventional DC (cDC1) vaccines drive tumor rejection through direct antigen presentation, without the need of endogenous cDC1. This suggests that cDC1-based vaccines could represent an optimal strategy to induce antitumor immunity in patients. See related article by Ferris et al., (7).

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