Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice

M. Englert,Katja Aurbach,Isabelle C. Becker,A. Gerber,T. Heib,L. M. Wackerbarth,C. Kusch,K. Mott,G. Araujo,A. Baig,Sebastian Dütting,U. Knaus,C. Stigloher,H. Schulze,B. Nieswandt,Irina Pleines,Z. Nagy

Published 2022 in Blood Advances

ABSTRACT

Key Points RhoB-deficient mice display microthrombocytopenia. RhoB exerts nonredundant functions in the megakaryocyte lineage compared with RhoA and regulates microtubule dynamics.

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