Cholesterol inhibits autophagy in RANKL-induced osteoclast differentiation through activating the PI3K/AKT/mTOR signaling pathway

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Molecular Biology Reports

• Publication date

  2022-07-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11033-022-07747-wPMID 35881223
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Systemic effects of abnormal bone resorption on muscle, metabolism, and cognition.

  2021cited by this paper
• Signaling pathways in human osteoclasts differentiation: ERK1/2 as a key player

  2021cited by this paper
• Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism

  2021cited by this paper
• Hydrogen sulphide promotes osteoclastogenesis by inhibiting autophagy through the PI3K/AKT/mTOR pathway

  2020cited by this paper
• Matrine induces apoptosis and autophagy in human lung adenocarcinoma cells via upregulation of Cavin3 and suppression of PI3K/AKT pathway.

  2020cited by this paper
• Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

  2020cited by this paper
• Ecdysone controlled cell and tissue deletion

  2019cited by this paper
• IL-17A modulates osteoclast precursors' apoptosis through autophagy-TRAF3 signaling during osteoclastogenesis.

  2019influential reference
• AP‐1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors

  2019cited by this paper
• Autophagy plays an essential role in bone homeostasis

  2019cited by this paper
• Autophagy-Mediated Cholesterol Trafficking Controls Steroid Production.

  2019cited by this paper
• miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway

  2019cited by this paper
• State of the art in osteoporosis risk assessment and treatment

  2019cited by this paper
• miR-363-3p is activated by MYB and regulates osteoporosis pathogenesis via PTEN/PI3K/AKT signaling pathway

  2019cited by this paper
• GABARAP promotes bone marrow mesenchymal stem cells‐based the osteoarthritis cartilage regeneration through the inhibition of PI3K/AKT/mTOR signaling pathway

  2019cited by this paper
• Interleukin-17A facilitates osteoclast differentiation and bone resorption via activation of autophagy in mouse bone marrow macrophages

  2019cited by this paper
• Autophagy regulates steroid production by mediating cholesterol trafficking in endocrine cells

  2019cited by this paper
• Strontium promotes osteogenic differentiation by activating autophagy via the the AMPK/mTOR signaling pathway in MC3T3-E1 cells

  2019cited by this paper
• Notch signaling inhibition protects against LPS mediated osteolysis.

  2019cited by this paper
• JNK1 regulates RANKL‐induced osteoclastogenesis via activation of a novel Bcl‐2‐Beclin1‐autophagy pathway

  2019cited by this paper
• RETRACTED ARTICLE: MicroRNA-183 affects the development of gastric cancer by regulating autophagy via MALAT1-miR-183-SIRT1 axis and PI3K/AKT/mTOR signals

  2019cited by this paper
• Swainsonine induces autophagy via PI3K/AKT/mTOR signaling pathway to injure the Renal Tubular Epithelial cells.

  2019cited by this paper
• Eldecalcitol effects on osteoblastic differentiation and function in the presence or absence of osteoclastic bone resorption

  2019cited by this paper
• Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands

  2019cited by this paper
• Autophagy in bone homeostasis and the onset of osteoporosis

  2019cited by this paper
• Combination therapies in the treatment of osteoporosis.

  2019cited by this paper
• The Regulation of Bone Metabolism and Disorders by Wnt Signaling

  2019cited by this paper
• SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells.

  2019cited by this paper
• The critical interplay between bone resorbing and bone forming cells.

  2019cited by this paper
• Protection Effect of Curcumin for Macrophage-Involved Polyethylene Wear Particle-Induced Inflammatory Osteolysis by Increasing the Cholesterol Efflux

  2019cited by this paper
• RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation

  2018cited by this paper
• PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis.

  2018cited by this paper
• EGFR‐mediated signaling pathway influences the sensitivity of oral squamous cell carcinoma to JQ1

  2018cited by this paper
• Interferon‐stimulated gene 15 promotes cholesterol efflux by activating autophagy via the miR‐17‐5p/Beclin‐1 pathway in THP‐1 macrophage‐derived foam cells

  2018cited by this paper
• Osteoprotegerin inhibit osteoclast differentiation and bone resorption by enhancing autophagy via AMPK/mTOR/p70S6K signaling pathway in vitro

  2018cited by this paper
• BMAL1 regulates balance of osteogenic–osteoclastic function of bone marrow mesenchymal stem cells in type 2 diabetes mellitus through the NF-κB pathway

  2018cited by this paper
• Osteoporosis and autophagy: What is the relationship?

  2017cited by this paper
• Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β‐Catenin and RANKL/OPG

  2016cited by this paper
• High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

  2015cited by this paper
• 17-Hydroxy-jolkinolide A inhibits osteoclast differentiation through suppressing the activation of NF-κB and MAPKs.

  2015cited by this paper
• miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway

  2015cited by this paper
• Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway.

  2014cited by this paper
• The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice

  2014cited by this paper
• The Phosphoinositide 3-Kinase Isoform PI 3 K Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice

  2014cited by this paper
• MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K/Akt signaling pathway.

  2014cited by this paper
• Class IA phosphatidylinositol 3‐kinase regulates osteoclastic bone resorption through protein kinase B–mediated vesicle transport

  2012cited by this paper
• Hypercholesterolemia promotes an osteoporotic phenotype.

  2012cited by this paper
• p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy*

  2012cited by this paper
• Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy.

  2011cited by this paper
• Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins

  2004cited by this paper
• Involvement of cholesterol in osteoclast-like cell formation via cellular fusion.

  1998cited by this paper

• Sclerostin-targeted delivery of PCSK9 siRNA reverses osteoporosis in OVX mice.

  2026cites this paper
• Regulation of osteoclast-mediated bone resorption by lipids.

  2025cites this paper
• Research on the role and mechanism of the PI3K/Akt/mTOR signalling pathway in osteoporosis

  2025cites this paper
• ERK inhibits osteoclast differentiation in RAW 264.7 cells through the osteoprotegerin-mediated autophagy.

  2025cites this paper
• Research progress on the role of autophagy in the development of varicocele.

  2024cites this paper
• Crosstalk between Lipid Metabolism and Bone Homeostasis: Exploring Intricate Signaling Relationships

  2024cites this paper
• [Akt2 inhibitor promotes M2 macrophage polarization in rats with periapical inflammation by reducing miR-155-5p expression].

  2023cites this paper
• Cumulative exposure to remnant cholesterol and the risk of fragility fractures: a longitudinal cohort study

  2023cites this paper
• Brevilin A inhibits RANKL-induced osteoclast differentiation and bone resorption.

  2023cites this paper
• mTOR Signaling Pathway in Bone Diseases Associated with Hyperglycemia

  2023cites this paper
• The Potential of Natural Compounds Regulating Autophagy in the Treatment of Osteoporosis

  2023cites this paper
• The role of circadian rhythm in osteoporosis; a review

  2022cites this paper