Does topical minoxidil at concentrations higher than 5% provide additional clinical benefit?

Minoxidil solution is used for the treatment of androgenetic alopecia (AGA). Minoxidil 5% solution has been shown to have superior efficacy to minoxidil 2% solution, it is unknown whether concentrations of minoxidil > 5% provide additional clinical benefit. We performed a review of the literature to examine the evidence on the efficacy and safety of higher concentrations of minoxidil in AGA. A search of the PubMed database was performed using the keywords ‘minoxidil’, ‘androgenic alopecia’ and ‘pattern hair loss’. Relevant articles, including clinical trials, other clinical studies, case series and case reports published in English were considered for review. In addition, relevant references from the bibliography section of the retrieved articles were also reviewed.

• Publication year

  2022

• Venue

  Clincal and Experimental Dermatology

• Publication date

  2022-07-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/ced.15338PMID 35881665
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Minoxidil-Coated Lysozyme-Shelled Microbubbes Combined With Ultrasound for the Enhancement of Hair Follicle Growth: Efficacy In Vitro and In Vivo

  2021cited by this paper
• Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

  2020cited by this paper
• Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss

  2020cited by this paper
• The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review

  2019cited by this paper
• Efficacy and safety of a new 10% topical minoxidil versus 5% topical minoxidil and placebo in the treatment of male androgenetic alopecia: a trichoscopic evaluation

  2019cited by this paper
• Minoxidil and its use in hair disorders: a review

  2019cited by this paper
• Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil treatment in Brazilian female pattern hair loss patients

  2019cited by this paper
• Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil.

  2016cited by this paper
• Topical Minoxidil: Systematic Review and Meta-Analysis of Its Efficacy in Androgenetic Alopecia.

  2015cited by this paper
• Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride

  2015cited by this paper
• Formulation and In Vitro Evaluation of Minoxidil Topical Gel

  2014cited by this paper
• Randomized clinical trial comparing 5% and 1% topical minoxidil for the treatment of androgenetic alopecia in Japanese men

  2009cited by this paper
• Is topical minoxidil solution effective on androgenetic alopecia in routine daily practice?

  2007cited by this paper
• A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men.

  2002cited by this paper
• The Pharmacokinetics of 2.5‐ to 10‐mg Oral Doses of Minoxidil in Healthy Volunteers

  1989cited by this paper
• Topical tretinoin for hair growth promotion.

  1986cited by this paper

• Enhanced Clinical Outcomes and Treatment Adherence in Patients Using Compounded Topical Minoxidil to Treat Androgenetic and Traction Alopecia.

  2025cites this paper
• A questionnaire-based survey among Indian dermatologists regarding the management of androgenetic alopecia with a novel formulation containing alcohol-free minoxidil, procapil and finasteride

  2025cites this paper
• Consensus Recommendations for the Management of Androgenetic Alopecia in Egypt: A Modified Delphi Study

  2025cites this paper
• Secondary Cutis Verticis Gyrata Induced by Long-Term Use of High-Dose Topical Minoxidil

  2024cites this paper
• Tolerance and safety profile of sublingual minoxidil in the treatment of androgenic alopecia.

  2024cites this paper
• Effect of cyclosporine A - Tempol topical gel for the treatment of alopecia and anti-inflammatory disorders.

  2023cites this paper
• Schizochytrium sp. Extracted Lipids Prevent Alopecia by Enhancing Antioxidation and Inhibiting Ferroptosis of Dermal Papilla Cells

  2023cites this paper
• Nanotechnology-based techniques for hair follicle regeneration.

  2023cites this paper
• Efficacy and safety of combinational therapy using topical minoxidil and microneedling for the treatment of androgenetic alopecia: a systematic review and meta-analysis

  2023cites this paper
• CASE AND

  year unknowncites this paper
• CASE AND RESEARCH

  year unknowncites this paper