ROS mediate proapoptotic and antisurvival activity of oleanane triterpenoid CDDO-Me in ovarian cancer cells.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Anticancer Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 23267148PMCID PMC3711076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-κB/mTOR signaling.

  2011cited by this paper
• Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism.

  2010cited by this paper
• CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells

  2009cited by this paper
• 4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-kappaB signaling pathways.

  2008cited by this paper
• The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents.

  2008cited by this paper
• Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-κB and Notch1 signaling

  2007cited by this paper
• The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-κB activation through direct inhibition of IκB kinase β

  2006cited by this paper
• The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta.

  2006cited by this paper
• The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

  2005cited by this paper
• The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells

  2005cited by this paper
• A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis

  2005cited by this paper
• The tor pathway: a target for cancer therapy

  2004cited by this paper
• The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Caspase-Dependent and -Independent Apoptosis in Acute Myelogenous Leukemia

  2004cited by this paper
• Cell respiration and formation of reactive oxygen species: facts and artefacts.

  2003cited by this paper
• Redox signaling and the MAP kinase pathways

  2003cited by this paper
• Cellular response to oxidative stress: Signaling for suicide and survival *

  2002cited by this paper
• Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

  2001cited by this paper
• Exploratory phase III study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancer.

  2000cited by this paper
• The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance.

  2000cited by this paper
• First line chemotherapy with carboplatin plus paclitaxel in advanced ovarian cancer--a new standard of care?

  1999cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Superoxide and hydrogen peroxide in relation to mammalian cell proliferation.

  1995cited by this paper
• Molecular genetics for the clinician

  1993cited by this paper
• Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds.

  1988cited by this paper
• Cancer,Facts and Figures about.

  year unknowncited by this paper

• Exploring the therapeutic potential of oleanolic acid and its derivatives in cancer treatment: a comprehensive review

  2025cites this paper
• Bardoxolone Methyl: A Comprehensive Review of Its Role as a Nrf2 Activator in Anticancer Therapeutic Applications

  2025cites this paper
• Current Research on the Control Mechanisms of Cell Survival and Proliferation as Potential Interaction Sites with Pentacyclic Triterpenoids in Ovarian Cancer

  2025cites this paper
• Bardoxolone methyl suppressed colorectal cancer cells in vitro by inhibiting the PI3K signaling pathway

  2025cites this paper
• Effects of leptin on the viability of human ovarian cancer cells and changes in cytokine expression levels

  2023cites this paper
• Cimigenoside Affects Cell Viability, Apoptosis and Metastasis Of A549 Cells Via The NF-κB Pathway

  2022cites this paper
• The role of nanomaterials in enhancing natural product translational potential and modulating endoplasmic reticulum stress in the treatment of ovarian cancer

  2022cites this paper
• Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

  2021cites this paper
• Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound: Effect of organobismuth(III) compound on NRF2 signaling.

  2020cites this paper
• Role of therapeutic agents on repolarisation of tumour-associated macrophage to halt lung cancer progression

  2020cites this paper
• ZhenQi FuZheng Formula Improves Mouse Hematopoietic Function after Cyclophosphamide-Induced Damage via Enhancing Macrophage Colony-Stimulating Factor Concentrations

  2020cites this paper
• The role of natural products in revealing NRF2 function.

  2020cites this paper
• The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2

  2020cites this paper
• Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy

  2019cites this paper
• Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids

  2019cites this paper
• Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis

  2019cites this paper
• New Challenges to Study Heterogeneity in Cancer Redox Metabolism

  2017cites this paper
• Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses

  2017cites this paper
• Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma

  2017cites this paper
• ViscumTT induces apoptosis and alters IAP expression in osteosarcoma in vitro and has synergistic action when combined with different chemotherapeutic drugs

  2017cites this paper
• Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy

  2017cites this paper
• Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut-brain-adipose axis

  2017influential citation
• Inhibitory Effects of 1-[2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oyl] Methyl Ester (CDDO-Me) and Curcumin on Multiple Myeloma Cell Growth

  2017cites this paper
• CDDO-Me reveals USP7 as a novel target in ovarian cancer cells

  2016cites this paper
• Oleanolic acid derivatives for pharmaceutical use: a patent review

  2016cites this paper
• Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

  2016cites this paper
• Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

  2015cites this paper
• Mechanisms of CDDO-imidazolide-mediated cytoprotection against acrolein-induced neurocytotoxicity in SH-SY5Y cells and primary human astrocytes.

  2015cites this paper
• Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells.

  2015cites this paper
• A Natural Combination Extract of Viscum album L. Containing Both Triterpene Acids and Lectins Is Highly Effective against AML In Vivo

  2015cites this paper
• Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me–induced apoptosis in breast cancer cells

  2015cites this paper
• Protection of HepG2 cells against acrolein toxicity by 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide via glutathione-mediated mechanism

  2015cites this paper
• Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

  2015cites this paper
• Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma.

  2015cites this paper
• induction of apoptosis and autophagy via sirtuin1-and Pi3K/akt/mTOr-mediated pathways by plumbagin in human prostate cancer cells

  2015cites this paper
• Targeting Nrf2 in inflammation and cancer

  2014cites this paper
• Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties

  2014cites this paper
• Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment

  2014cites this paper
• Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.

  2014cites this paper
• Triterpenoids as reversal agents for anticancer drug resistance treatment.

  2014cites this paper
• SPEEN, ADAM M., M.S. Enhancement of Endogenous Glutathione and NQO1 by Triterpenoid CDDO-Im in SH-SY5Y Cells: Protection Against Neurotoxicant-

  2013cites this paper
• Protection of HepG2 cells from acrolein toxicity by CDDO-Im via glutathione-mediated mechanism

  2013cites this paper