Phytochemical and pharmacological investigation of some medicinal plants for the treatment of hepatoprotective & antioxidant activity

The plant Luffa acutangula var. Amara is used by native practitioners. Presently, it is planned to make petroleum ether, alcohol, and aqueous extracts of this plant's fruits before undertaking blind screening trials to examine the antidiabetic, hepatoprotective, and antibacterial effects of the fruits and validate native practitioners' claims. The powdered whole fruits were extracted with petroleum ether, alcohol and chloroform water. The LD50 values for all these extracts were found to be 70 mg/kg, 500 mg/kg, and 15g/kg respectively. Alloxan-induced diabetes in 150-200g albino rats was tested for antidiabetic effects and compared to glibenclamide. Albino rats treated with CCl4, a liver toxicant, had increased SGOT, SGPT, SALP, direct and total bilirubin, serum cholesterol, and serum triglyceride levels. Compared to CCl4-treated group, findings were significant. In a CCl4 hepatotoxic model, alcoholic and aqueous extracts significantly decreased wet liver weight and volume, indicating hepatoprotective action. Histopathological abnormalities (fatty infiltration, necrosis, etc.) were normalised in aqueous and alcoholic extract groups.

• Publication year

  2022

• Venue

  International Journal of Health Sciences

• Publication date

  2022-06-30

• Fields of study

  Not labeled

• Identifiers
  DOI 10.53730/ijhs.v6ns5.10035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti-Cancer Cyclodextrin Nanocapsules Based Formulation Development for Lung Chemotherapy

  2021cited by this paper
• Health and treatment of diabetes mellitus

  2021cited by this paper
• Effect of Extraction Method on Antimicrobial Activity Against Staphylococcus Aureus of Tapak Liman (Elephantopus Scaber L.) Leaves

  2020cited by this paper
• Glipizide versus tolbutamide, an open trial

  2005cited by this paper
• Drug-induced hepatotoxicity.

  2003cited by this paper
• Luffangulin, a novel ribosome inactivating peptide from ridge gourd (Luffa acutangula) seeds.

  2002cited by this paper
• Nephropathy in patients with type 2 diabetes mellitus.

  1999cited by this paper
• Goodman and Gilman 's: The pharmacological basis of therapeutics

  1996cited by this paper
• Hepatic injury due to drugs and toxin

  1994cited by this paper
• Studies on the constituents of Luffa acutangula Roxb. I. Structures of acutosides A--G, oleanane-type triterpene saponins isolated from the herb.

  1991cited by this paper
• Isolation, macromolecular properties, and combining site of a chito-oligosaccharide-specific lectin from the exudate of ridge gourd (Luffa acutangula).

  1986cited by this paper
• THE LIVER

  1968cited by this paper
• Principles of Anatomy and Physiology

  1911cited by this paper

• No citing papers are available for this paper.