Platelets Exposed to Elevated Levels of Endogenous Thrombopoietin In Vivo Have a Reduced Response to Megakaryocyte Growth and Development Factor In Vitro

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Thrombosis and Haemostasis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1055/s-0037-1612918PMID 11204567
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantitative analysis of thrombopoietin receptors on human megakaryocytes

  1998cited by this paper
• Proliferative properties of human umbilical cord blood megakaryocyte progenitor cells to human thrombopoietin.

  1998cited by this paper
• Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice.

  1998cited by this paper
• Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera.

  1998cited by this paper
• Binding and regulation of thrombopoietin to human megakaryocytes

  1998cited by this paper
• Reactivity of Platelets from Healthy Individuals and from Patients with Hematologic Diseases following Incubation with Pegylated RecombinantHuman Megakaryocyte Gr owth and Development Factor in vitro

  1998cited by this paper
• Thrombocytopenia with absent radii syndrome: studies on serum thrombopoietin levels and megakaryopoiesis in vitro.

  1998cited by this paper
• Metabolism of thrombopoietin (TPO) in vivo: determination of the binding dynamics for TPO in mice.

  1997cited by this paper
• Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia.

  1997cited by this paper
• Serum Thrombopoietin Level Is Not Regulated by Transcription but by the Total Counts of both Megakaryocytes and Platelets during Thrombocytopenia and Thrombocytosis

  1997cited by this paper
• Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin.

  1997cited by this paper
• Influence of thrombopoietin on platelet activation in myeloproliferative disorders

  1997cited by this paper
• Improvement of thrombocytopenia following bone marrow transplantation by pegylated recombinant human megakaryocyte growth and development factor in mice

  1997cited by this paper
• Human platelets as a model for the binding and degradation of thrombopoietin.

  1997cited by this paper
• Human platelets display high-affinity receptors for thrombopoietin.

  1997cited by this paper
• Action of thrombopoietin at the megakaryocyte progenitor level is critical for the subsequent proplatelet production.

  1997cited by this paper
• Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin.

  1997cited by this paper
• Thrombopoietin in patients with congenital thrombocytopenia and absent radii: elevated serum levels, normal receptor expression, but defective reactivity to thrombopoietin.

  1997cited by this paper
• Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro

  1997cited by this paper
• Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists.

  1996cited by this paper
• Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy.

  1996cited by this paper
• Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.

  1996cited by this paper
• Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation.

  1996cited by this paper
• Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets.

  1996cited by this paper
• Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3.

  1996cited by this paper
• Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates.

  1996cited by this paper
• Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets.

  1996influential reference
• GpIIb/IIIa+ subpopulation of rat megakaryocyte progenitor cells exhibits high responsiveness to human thrombopoietin.

  1996cited by this paper
• Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2.

  1996cited by this paper
• The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells.

  1996cited by this paper
• Effects of recombinant human megakaryocyte growth and development factor on platelet activation.

  1996cited by this paper
• Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy‐induced thrombocytopenia

  1996cited by this paper
• In Vivo Effects of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor on Hematopoiesis in Normal Mice

  1996cited by this paper
• Relative reactivity of platelets from thrombopoietin- and interleukin-6-treated dogs.

  1996cited by this paper
• Effects of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor on Thrombocytopenia Induced by a New Myelosuppressive Chemotherapy Regimen in Mice

  1996cited by this paper
• Megakaryocyte growth and development factor (MGDF) moderately enhances in-vitro platelet aggregation.

  1995cited by this paper
• Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin.

  1995cited by this paper
• Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

  1995cited by this paper
• Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia.

  1995cited by this paper
• Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro.

  1995cited by this paper
• Purification and characterization of thrombopoietin.

  1995cited by this paper
• Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors.

  1995cited by this paper
• Modulation of Platelet Activation In Vitro by Thrombopoietin

  1995influential reference
• Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates.

  1995cited by this paper
• Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets.

  1995influential reference
• Automated measurement of reticulated platelets in estimating thrombopoiesis

  1995cited by this paper
• Thrombopoietin, c‐Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists‐induced aggregation in platelets in vitro

  1995influential reference
• The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl (*)

  1995cited by this paper
• Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice.

  1995cited by this paper
• Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

  1994cited by this paper
• The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.

  1994cited by this paper
• Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

  1994cited by this paper
• Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

  1994cited by this paper
• Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

  1994cited by this paper
• Proteasome and its novel endogeneous activator in human platelets.

  1991cited by this paper
• Flow cytometric analysis of thiazole orange uptake by platelets: a diagnostic aid in the evaluation of thrombocytopenic disorders.

  1990cited by this paper
• Demonstration of Secondary Lysosomes in Bovine Megakaryocytes and Platelets Using Acid Phosphatase Cytochemistry with Cerium as a Trapping Agent

  1990cited by this paper
• Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

  1962cited by this paper

• Thrombopoietin as Biomarker and Mediator of Cardiovascular Damage in Critical Diseases

  2012cites this paper
• Hepatocyte growth factor accelerates thrombopoiesis in transgenic mice

  2007cites this paper
• Transgene Insertion in Proximity to the c- myb Gene Disrupts Erythroid-Megakaryocytic Lineage Bifurcation (cid:1)

  2006cites this paper
• Transgene Insertion in Proximity to thec-myb Gene Disrupts Erythroid-Megakaryocytic Lineage Bifurcation

  2006cites this paper
• Thrombopoietin contributes to enhanced platelet activation in patients with unstable angina.

  2006cites this paper
• Decreased prothrombotic effects of pegylated recombinant human megakaryocyte growth and development factor in thrombocytopenic state in a rat thrombosis model

  2005cites this paper
• Ticlopidine Inhibits the Prothrombotic Effects of Thrombopoietin and Ameliorates Survival after Supralethal Total Body Irradiation

  2002cites this paper
• Marked improvement of thrombocytopenia in a murine model of idiopathic thrombocytopenic purpura by pegylated recombinant human megakaryocyte growth and development factor.

  2002cites this paper