Crystal structures of human IPP isomerase: new insights into the catalytic mechanism.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Molecular Biology

• Publication date

  2007-03-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.JMB.2006.10.092PMID 17137593
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Automated structure solution with autoSHARP.

  2007cited by this paper
• Structural Role for Tyr-104 in Escherichia coli Isopentenyl-diphosphate Isomerase

  2006cited by this paper
• Escherichia coli type I isopentenyl diphosphate isomerase: structural and catalytic roles for divalent metals.

  2006cited by this paper
• A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase.

  2005cited by this paper
• The Vγ2/Vδ2 T‐cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vγ2/Jγ1.2 subset

  2005cited by this paper
• Immune regulation of γδ T cell responses in mycobacterial infections

  2005cited by this paper
• Immune regulation of gammadelta T cell responses in mycobacterial infections.

  2005cited by this paper
• The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vgamma2/Jgamma1.2 subset.

  2005cited by this paper
• Post-prenylation-processing enzymes as new targets in oncogenesis

  2005cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.

  2004cited by this paper
• Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates.

  2004cited by this paper
• Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate.

  2004cited by this paper
• Crystal structure of the C67A mutant of isopentenyl diphosphate isomerase complexed with a mechanism‐based irreversible inhibitor

  2003cited by this paper
• Macromolecular TLS refinement in REFMAC at moderate resolutions.

  2003cited by this paper
• Catalytic Mechanism of Escherichia coli Isopentenyl Diphosphate Isomerase Involves Cys-67, Glu-116, and Tyr-104 as Suggested by Crystal Structures of Complexes with Transition State Analogues and Irreversible Inhibitors*

  2003cited by this paper
• Zinc is an essential cofactor for type I isopentenyl diphosphate:dimethylallyl diphosphate isomerase.

  2003cited by this paper
• Structure and mechanism of action of isopentenylpyrophosphate-dimethylallylpyrophosphate isomerase.

  2003cited by this paper
• Substructure solution with SHELXD.

  2002cited by this paper
• Phosphoantigen Presentation by Macrophages to Mycobacterium tuberculosis-Reactive Vγ9Vδ2+ T Cells: Modulation by Chloroquine

  2002cited by this paper
• Phosphoantigen presentation by macrophages to mycobacterium tuberculosis--reactive Vgamma9Vdelta2+ T cells: modulation by chloroquine.

  2002cited by this paper
• Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase

  2001cited by this paper
• T-Coffee: A novel method for fast and accurate multiple sequence alignment.

  2000cited by this paper
• Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway.

  1999cited by this paper
• Escherichia coli Open Reading Frame 696 Is idi, a Nonessential Gene Encoding Isopentenyl Diphosphate Isomerase

  1999cited by this paper
• Automated protein model building combined with iterative structure refinement

  1999cited by this paper
• ESPript: analysis of multiple sequence alignments in PostScript

  1999cited by this paper
• Creating Isoprenoid Diversity

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• MOLREP: an Automated Program for Molecular Replacement

  1997cited by this paper
• Cloning and Subcellular Localization of Hamster and Rat Isopentenyl Diphosphate Dimethylallyl Diphosphate Isomerase

  1997cited by this paper
• Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.

  1996cited by this paper
• Identification of Cys139 and Glu207 as catalytically important groups in the active site of isopentenyl diphosphate:dimethylallyl diphosphate isomerase.

  1994cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• Isopentenyl-diphosphate isomerase: irreversible inhibition by 3-methyl-3,4-epoxybutyl diphosphate.

  1992cited by this paper
• Hydrogen exchange during the enzyme-catalyzed isomerization of isopentenyl diphosphate and dimethylallyl diphosphate

  1990cited by this paper
• Isopentenyl-diphosphate isomerase: inactivation of the enzyme with active-site-directed irreversible inhibitors and transition-state analogues.

  1988cited by this paper
• Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate.

  1986cited by this paper
• Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

  1983cited by this paper
• Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate.

  1966cited by this paper
• Biosynthesis of terpenes. I. Chromatography of peppermint oil terpenes.

  1961cited by this paper
• Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase.

  1960cited by this paper
• Studies on the biosynthesis of cholesterol: V. C14-Cholesterol in the egg yolk and in the laying hen

  1953cited by this paper
• Electronic Reprint Biological Crystallography a Molecular Viewer for the Analysis of Tls Rigid-body Motion in Macromolecules Biological Crystallography a Molecular Viewer for the Analysis of Tls Rigid-body Motion in Macromolecules

  year unknowncited by this paper

• Functional Identification of the Isopentenyl Diphosphate Isomerase Gene from Fritillaria unibracteata

  2024cites this paper
• Lanosterol biosynthesis pathway in GtoPdb v.2023.1

  2023cites this paper
• Metalloenzymes involved in carotenoid biosynthesis in plants.

  2022cites this paper
• Lanosterol biosynthesis pathway (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• A novel plant enzyme with dual activity: an atypical Nudix hydrolase and a dipeptidyl peptidase III

  2017cites this paper
• Engineering the methylerythritol phosphate pathway in cyanobacteria for photosynthetic isoprene production from CO2

  2016cites this paper
• HbIDI, SlIDI and EcIDI: A comparative study of isopentenyl diphosphate isomerase activity and structure.

  2016cites this paper
• Mechanistic aspects of carotenoid biosynthesis.

  2014cites this paper
• Structural and biochemical perspectives in plant isoprenoid biosynthesis

  2013cites this paper
• Biosynthesis of Terpenoids

  2013cites this paper
• Regulation of the carotenoid biosynthetic pathway in petals of California poppy (Eschscholzia californica) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Biology at Massey University, Palmerston North, New Zealand

  2012cites this paper
• Isopentenyl diphosphate isomerase: A checkpoint to isoprenoid biosynthesis.

  2012cites this paper
• Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction.

  2012cites this paper
• Reducing of phorbol ester content in callus cultures of physic nut (Jatropha Curcas L.) using manganese chloride and n-ethylmaleimid

  2011cites this paper
• Molecular cloning and expression analysis of a new putative gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase from Salvia miltiorrhiza

  2011cites this paper
• Mevalonate Pathway in Bacteria and Archaea

  2010cites this paper
• Clonagem, caracterização e expressão de genes envolvidos na síntese de compostos isoprenóides em Eucalyptus grandis

  2010cites this paper
• 1.12 – Mevalonate Pathway in Bacteria and Archaea

  2010cites this paper
• The intermediate enzymes of isoprenoid metabolism as anticancer targets.

  2009cites this paper
• Cloning and molecular characterization of two complement Bf/C2 genes in large yellow croaker (Pseudosciaena crocea).

  2009cites this paper
• Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes.

  2008cites this paper
• Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms.

  2008cites this paper
• The Non-mevalonate Pathway of Isoprenoid Precursor Biosynthesis*

  2007cites this paper
• Identification and Functional Analysis of Two Novel Genes—Geranylgeranyl Pyrophosphate Synthase Gene ( AlGGPPS ) and Isopentenyl Pyrophosphate Isomerase Gene ( AlIDI )—from Aurantiochytrium limacinum Significantly Enhance De Novo β -Carotene Biosynthesis in Escherichia coli

  year unknowncites this paper
• Biological Chemistry 'just Accepted' Papers a Novel Plant Enzyme with Dual Activity: an Atypical Nudix Hydrolase and a Dipeptidyl Peptidase Iii New Plant Hydrolase with Ipp Dephosphorylation Ability New Plant Hydrolase with Ipp Dephosphorylation Ability Introduction

  year unknowncites this paper