Comprehensive Review on the Bis–heterocyclic Compounds and their Anticancer Efficacy

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Journal of Molecular Structure

• Publication date

  2022-08-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/j.molstruc.2022.133970
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel spiroheterocycles containing a 1,3,4-thiadiazole unit: Synthesis and spectroscopic characterization

  2022cited by this paper
• Analysis and prediction pathways of natural products and their cytotoxicity against HeLa cell line protein using docking, molecular dynamics and ADMET

  2021cited by this paper
• Ionic interaction of tri-armed structure based on benzene ring: synthesis and characterization

  2021cited by this paper
• Study of Selected Flavonoid Structures and Their Potential Activity as Breast Anticancer Agents

  2021cited by this paper
• Design, one-pot green synthesis and antimicrobial evaluation of novel imidazopyridine bearing pyran bis-heterocycles

  2020cited by this paper
• Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates

  2020cited by this paper
• The role of SIRT2 in cancer: A novel therapeutic target

  2020cited by this paper
• Facile one‐pot, three‐component synthesis of novel bis(heterocycles) incorporating thieno[2,3‐b]thiophenes via Michael addition reaction

  2020cited by this paper
• Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

  2020cited by this paper
• Synthesis and Biological Evaluation of Some Novel Bis-Thiadiazoles as Antimicrobial and Antitumor Agents

  2020cited by this paper
• ZnO nanoparticles catalyzed synthesis of bis- and poly(imidazoles) as potential anticancer agents

  2020cited by this paper
• One‐Pot Construction of Bis‐Heterocycles through Isocyanide Based Multicomponent Reactions

  2020cited by this paper
• An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities

  2020cited by this paper
• Encapsulation of Nedaplatin in Novel PEGylated Liposomes Increases Its Cytotoxicity and Genotoxicity against A549 and U2OS Human Cancer Cells

  2020cited by this paper
• Rosuvastatin Myotoxicity After Starting Canagliflozin Treatment: A Case Report

  2020cited by this paper
• Ruthenium complexes with mono- or bis-heterocyclic chelates: DNA/BSA binding, antioxidant and anticancer studies

  2020cited by this paper
• Synthesis, Molecular Docking and Antitumor Activity of New Dithiazoles

  2019cited by this paper
• Contrasting the impact of cytotoxic and cytostatic drug therapies on tumour progression

  2019cited by this paper
• Rhodanine‐Furan Bis‐Heterocyclic Frameworks Synthesis via Green One‐Pot Sequential Six‐Component Reactions: A Synthetic and Computational Study

  2019cited by this paper
• Polynuclear Ag(I)-N-heterocyclic carbene complexes: synthesis, electrochemical and in vitro anticancer study against human breast cancer and colon cancer

  2019cited by this paper
• N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.

  2019cited by this paper
• Intramolecular Ring Transformation of Bis-oxadiazoles to Bis-thiadiazoles and Investigation of Their Anticancer Activities

  2018cited by this paper
• Mechanisms of cancer resistance in long-lived mammals

  2018cited by this paper
• Synthesis, characterization, and bioactivity of new bisamidrazone derivatives as possible anticancer agents

  2018cited by this paper
• An Overview of Cancer Treatment Modalities

  2018cited by this paper
• Synthesis andIn VitroAnticancer Evaluation of Symmetrically Bridged 1,3-thiazine Derivatives

  2018cited by this paper
• Novel Nano-sizedbis-indoline Derivatives as Antitumor Agents

  2018cited by this paper
• Malononitrile dimer as a privileged reactant in design and skeletal diverse synthesis of heterocyclic motifs

  2018cited by this paper
• Synthesis, Molecular Docking, and Biological Evaluation of Some Novel Bis‐heterocyclic Compounds Based N , N ′‐([1,1′‐biphenyl]‐4,4′‐diyl)bis(2‐cyanoacetamide) as Potential Anticancer Agents

  2018cited by this paper
• A Review: Biological Importance of Heterocyclic Compounds

  2017cited by this paper
• A review on the effects of current chemotherapy drugs and natural agents in treating non–small cell lung cancer

  2017cited by this paper
• Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes

  2017cited by this paper
• New Bis(dihydropyridine‐3,5‐dicarbonitrile) Derivatives: Green Synthesis and Cytotoxic Activity Evaluation

  2017cited by this paper
• Recent Approaches to Platinum(IV) Prodrugs: A Variety of Strategies for Enhanced Delivery and Efficacy.

  2017cited by this paper
• Bis-Hydrazonoyl chloride as precursors for synthesis of novel polysubstituted bis-azoles

  2017cited by this paper
• DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity.

  2016cited by this paper
• Heterocyclisation of 2,5-diacetyl-3,4-disubstituted-thieno[2,3-b]Thiophene Bis-Thiosemicarbazones Leading to Bis-Thiazoles and Bis-1,3,4-thiadiazoles as Anti-breast Cancer Agents

  2016cited by this paper
• Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents

  2016cited by this paper
• Cost-effectiveness of sofosbuvir-based treatments for chronic hepatitis C in the US

  2015cited by this paper
• Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box

  2015cited by this paper
• Aripiprazole (ABILIFY MAINTENA®): A Review of Its Use as Maintenance Treatment for Adult Patients with Schizophrenia

  2014cited by this paper
• Cancer and Radiation Therapy: Current Advances and Future Directions

  2012cited by this paper
• Heterocycles in drugs and drug discovery

  2012cited by this paper
• Combinatorial libraries of bis-heterocyclic compounds with skeletal diversity.

  2008cited by this paper
• DNA repair pathways as targets for cancer therapy

  2008cited by this paper
• Cytotoxic T cells.

  2006cited by this paper
• Why we're losing the war on cancer (and how to win it).

  2004cited by this paper

• Efficient one-pot synthesis of bis-benzothiazoles from dicarboxylic acids: A metal-free benzotriazole strategy

  2026cites this paper
• Synthesis, Antimicrobial Activity, and Molecular Docking Studies of New Quinoxaline‐Heterocycle Hybrids

  2026cites this paper
• Synthesis, antibacterial activities, and molecular docking of bis(1,3,4a,9-tetraza-4H-fluoren-2-amines) derivatives bearing aliphatic or aromatic spacers via (phenoxy) linkages

  2026cites this paper
• Enantioselective rapid assembly of bis-heterocycles by sequential palladium-catalyzed aza-Heck cyclization coupling reaction

  2026cites this paper
• Synthesis and Application of MOF(Fe)-TUR as a New H-Bond Catalyst for Synthesis of New Nicotinonitriles and Chromeno[4,3-b] Pyridines

  2025cites this paper
• Heterocyclic Coumarin Derivatives as Multifunctional Biosafe Candidates: Bridging Synthetic Chemistry with In Vitro and In Silico Evaluations

  2025cites this paper
• Reevaluating 1,3‐Thiazolidinone Reports: Deciphering the Authentic 1,3‐Thiazolidinone Frameworks via Synthetic and Spectroscopic Insights

  2025cites this paper
• Synthesis, characterization and cytotoxic effect of 2-((E)-((E)-2-(5-chloro-3,3-dimethylindolin-2-ylidene)-3-oxopropylidene) amino) benzoic acid on the MCF7 cancer cell line

  2025cites this paper
• Design, synthesis, and in-Silco ADME prediction of some novel bis(1,3,4-thiadiazoles) encapsulated lipid chitosan nano capsule decorative with magnetic nanoparticles and their potential anti-helicobacter pylori activity.

  2025cites this paper
• Chiral Oxazoline-Triazole-Benzothiazole Molecular Triads: Photoactive Sensors for Enantioselective Carbohydrate Recognition in Solution

  2025cites this paper
• Microwave-assisted synthesis and in vitro and in silico studies of pyrano[3,2-c]quinoline-3-carboxylates as dual acting anti-cancer and anti-microbial agents and potential topoisomerase II and DNA-gyrase inhibitors

  2025cites this paper
• One-pot synthesis of novel 5-(azidomethyl)-2-aryloxazole derivatives from propargylamide through Cu-catalyzed C–N bond formation

  2025cites this paper
• Ylide-Induced Ring Contraction of Coumarins to Benzofurans: Applications to the Synthesis of Bis-Heterocycles.

  2025cites this paper
• Development of heterocyclic-based anticancer agents: A comprehensive review

  2025cites this paper
• GCMS, phytochemical analysis, biological potential of dichloromethane extract of Yucca elephantipes regel roots: in vitro and in silico studies.

  2025cites this paper
• Thiazolopyrimidine, a privileged scaffold: Recent updates on synthetic and pharmacological perspective in drug discovery

  2025cites this paper
• Synthesis and Evaluation of Isosteviol Derivatives: Promising Anticancer Therapies for Colon Cancer

  2025cites this paper
• Modern Strategies of Drug Therapy: Multi-Target Drug Delivery, Bioimaging, Diagnostics

  2025cites this paper
• Synthesis of Novel Isoindolinones: Carbonic Anhydrase Inhibition Profiles, Antioxidant Potential, Antimicrobial Effect, Cytotoxicity and Anticancer Activity

  2025cites this paper
• Electrochemically Promoted Multicomponent Approach for the Synthesis of trans‐2,3‐Dihydrobenzofuran Derivatives and Study of Their DNA Cleavage and Anticancer Activity

  2025cites this paper
• Novel Hybrid Heterocycles Based on 1,4-Diphenylpiperazine Moiety: Synthesis via Hantzsch and Biginelli Reactions, Molecular Docking Simulation, and Antimicrobial Activities

  2025cites this paper
• Palladium/Xu‐Phos‐Catalyzed Enantioselective Cascade Heck/Intermolecular Direct Heteroarylation Reaction

  2025cites this paper
• Eco-friendly Biginelli reaction via copper–chitosan catalyst

  2025cites this paper
• Enantioselective Palladium-Catalyzed Domino Carboetherification Reaction: Access to Isoxazoline-Linked Bis-Heterocycles.

  2025cites this paper
• Bisquinoline as a promising scaffold in anti-infective drug discovery: the current state of the art and future prospects

  2025cites this paper
• One-Pot Synthesis of 3-Tetrazolylmethyl-4H-Chromen-4-Ones via Ugi-Azide Reaction

  2025cites this paper
• Palladium-catalyzed tandem cyclization reaction: access to isoxazoline-benzofuran bis-heterocycles.

  2025cites this paper
• Synthesis, molecular modeling and harnessing the antimicrobial activity of new pyrazine-thiadiazole hybrids

  2025cites this paper
• Regioisomeric polyether-linked bis-hydrazothiazoles: architecture as cancer terminators in liver carcinoma via apoptosis.

  2025cites this paper
• One-pot synthesis of new bis(2,4′-bipyridine), bis(pyrrole), and bis(benzo[f]chromene) derivatives: Antimicrobial evaluation, molecular docking, DFT, and ADME profiling

  2025cites this paper
• Synthesis of Novel Hybrid Heterocycles Tethered 2,3‐Diphenoxyquinoxaline Moiety via Hantzsch, Michael, and Biginelli Reactions: Antimicrobial Activities and Molecular Docking Simulation

  2025cites this paper
• Exploring the optoelectronic and photovoltaic potential of Spiro-OMeTAD derivatives through quantum chemical investigations

  2025cites this paper
• Preparation, spectral characterization, in silico ADME studies, molecular docking, and antioxidant activity of some derivatives of the Oxazepine symmetrical dimers

  2025cites this paper
• Novel bis-Thiazolidinone -based chalcones with pyridine linker: Eco-friendly synthesis, cholinesterase and beta-amyloid inhibition potency, and molecular docking studies.

  2025cites this paper
• PIDA-Mediated Synthesis of Symmetrical 1,2,4,5-Tetrazine Using N -Tosylhydrazones

  2025cites this paper
• Synthesis and Anticancer Activity Study of New Bis‐1,3‐Oxazole‐5‐Sulfonylamides

  2025cites this paper
• Recent progress on anti-cancer activity of thiadiazoles: A review

  2024cites this paper
• Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions

  2024cites this paper
• Synthesis, molecular docking, and antimicrobial activity of novel scaffolds based on bis-thiazole linked to 2-phenoxy-N-arylacetamide as new hybrid molecules

  2024cites this paper
• (1E,3E)-1,4-Dinitro-1,3-butadiene—Synthesis, Spectral Characteristics and Computational Study Based on MEDT, ADME and PASS Simulation

  2024cites this paper
• Bis(2-cyanoacetamide) in Heterocyclic Synthesis: Synthesis of Some Bis[2-oxopyridine, 2-iminochromene, Chromeno[3,4-c]pyridine, Benzochromeno[3,4-c]pyridine] Derivatives

  2024cites this paper
• Synthesis, Crystal Structure, Hirshfeld Surface Analysis, Computational Investigations and Molecular Docking Studies of (Z)-3-N-(methyl)-2-N’-(4-methoxyphenylimino) thiazolidin-4-one dihydrate

  2024cites this paper
• Revisiting methotrexate and phototrexate Zinc15 library-based derivatives using deep learning in-silico drug design approach

  2024cites this paper
• Synthesis and computational insights of hybrid heterocyclic bis-chalcone compounds and their cytotoxic effects against breast cancer cells

  2024cites this paper
• Synthesis and Anti‐Bacterial Evaluation of Novel Scaffolds Based on Bis‐Thiazole or bis‐1,3,4‐Thiadiazole Linked to Thieno[2,3‐b]Thiophene as New Hybrid Molecules

  2024cites this paper
• Synthesis, molecular docking, in silico study, and evaluation of bis-thiazole-based curcumin derivatives as potential antimicrobial agents

  2024cites this paper
• Novel bis([triazolo[3,4-b]thiadiazoles and bis([triazolo[3,4-b][thiadiazines) with antioxidant activity

  2024cites this paper
• Novel heterocyclic coumarin annulates: synthesis and figuring their roles in biomedicine, bench-to-bedside investigation

  2024cites this paper
• Synthesis, molecular structure, Hirshfeld surface analysis, NCI-RDG, spectral characterization analysis, Nonlinear optical properties, and in silico molecular docking of (E)-3-(3-(2-methoxyphenyl)-4-methylthiazol-2(3H)-ylidene) benzo[4,5] imidazo [1,2-c] thiazole-1(3H)-thione

  2024cites this paper
• Exploring quinoxaline derivatives: An overview of a new approach to combat antimicrobial resistance.

  2024cites this paper
• Identification and in silico screening of natural phloroglucinols as potential PI3Kα inhibitors: A computational approach for drug discovery

  2024cites this paper
• Advances in cyclizative dimerization of alkynes and allenes for the complex bis-heterocyclic compounds synthesis

  2024cites this paper
• Development of a new heterogeneous catalyst based on triple superphosphate for the one-pot multicomponent synthesis via green strategy, accompanied by a critical assessment of environmental sustainability metrics applied to the synthesis of 2,4,5-tri and 1,2,4,5-tetra substituted imidazole heterocyc

  2024cites this paper
• Pyrazoline Spiro-oxindole tethered 1,2,3-triazole hybrids: Design, synthesis, antimicrobial efficacy and molecular modelling studies

  2024cites this paper
• Accumulation Characteristics of Natural Ophiocordyceps sinensis Metabolites Driven by Environmental Factors

  2024cites this paper
• One-pot three-component synthesis of 2,4-dimethoxy-5,8,9,10-tetrahydropyrimido[4,5-b]quinolinone derivatives along with in silico and in vitro investigation of their antimalarial activity

  2024cites this paper
• The synthesis and study of antimicrobial activity of 5-oxo-1-(thiazol-2-yl)pyrrolidine-3-carboxylic acids

  2024cites this paper
• Unexpected Course of Reaction Between (1E,3E)-1,4-Dinitro-1,3-butadiene and N-Methyl Azomethine Ylide—A Comprehensive Experimental and Quantum-Chemical Study

  2024cites this paper
• Caffeine-catalyzed green synthesis of biscoumarins

  2024cites this paper
• Exploring heterocyclic scaffolds in carbonic anhydrase inhibition: a decade of structural and therapeutic insights

  2024cites this paper
• Synthesis, antimicrobial, DNA binding, and computational studies of some bis- and poly(4-methyl-2H-chromen-2-one) derivatives

  2024cites this paper
• C–H Functionalization of Imidazo[1,5-a]pyridines: A Metal-Free Approach for Methylene Insertion to Access C(sp2)–C(sp3)–H–C(sp2) Bond Formation

  2024cites this paper
• Synthesis, identification and application of a new ionic liquid based on 1-vinylimidazole, immobilized on graphene oxide nanosheets

  2024cites this paper
• Synthesis, Biological Activity, and Molecular Docking Study of New Triazoline Derivatives Using 2-Amino-5-p-subtituted Phenyl-1,3,4-thiadiazoles

  2024cites this paper
• New symmetric 1,1′-bipyrrolidine-2,2′-diones as products of recyclization of itaconimides with hydrazine

  2024cites this paper
• Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers

  2023cites this paper
• Molecular modeling and cytotoxic activity of new thiadiazole-pyrazole hybridized with thiazole

  2023cites this paper
• A novel imidazole-based azo molecule: synthesis, characterization, quantum chemical calculations, molecular docking, molecular dynamics simulations and ADMET properties

  2023cites this paper
• Novel mitochondrial and DNA damaging fluorescent Calix[4]arenes bearing isatin groups as aromatase inhibitors: Design, synthesis and anticancer activity.

  2023cites this paper
• Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets.

  2023cites this paper
• New bis-heterocyclic structures: Synthesis, characterization and biological activity

  2023cites this paper
• Unsymmetrical Bis‐Coumarin Based on o‐Hydroxy Aldehydes and 4‐Hydroxy Coumarin: Expedient Synthesis, Single Crystal X‐rays and DFT Studies

  2023cites this paper
• Rapid Assembly of Unsymmetrically Linked Bis-heterocycles via Palladium Domino Catalysis.

  2023cites this paper
• Pictet–Spengler-Based Multicomponent Domino Reactions to Construct Polyheterocycles

  2023cites this paper
• Synthesis of Schiff Bases Based on Chitosan and Heterocyclic Moiety: Evaluation of Antimicrobial Activity

  2023cites this paper
• Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy-N-arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations

  2023cites this paper
• Novel diphenyl ether-heterocycles hybrids: Synthesis via Hantzsch and Biginelli reactions, molecular docking simulation, and antimicrobial activities

  2023cites this paper
• Surface modification of chitosan with Ni(II) Schiff base complex: A new heterogeneous catalyst for the synthesis of xanthones.

  2023cites this paper
• Fe3O4@SiO2@BHA-Cu(II) as a new, effective, and magnetically recoverable catalyst for the synthesis of polyhydroquinoline and tetrazole derivatives

  2023cites this paper
• Pyrazolo[5,1‐b]quinazolines and Their Bis‐analogues Linked to Different Spacers: Regioselective Synthesis, Antibacterial Screening and SwissADME Prediction Study

  2023cites this paper
• Straightforward synthesis of quinoxaline-furan bis-heterocyclic structures via a multicomponent reaction

  2023cites this paper
• Syntheses and Antioxidant Activity of 1-Isonicotinoyl-4-phenylthiosemicarbazide and Crystal Structures of N-Phenyl-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amine Hydrochloride and 4-Phenyl-3-(pyridin-4-yl)-1H-1,2,4-triazole-5(4H)-thione derived from 1 Isonicotinoyl-4-phenylthiosemicarbazide

  2022cites this paper
• Original Research Article Synthesis of Dioxane-fused Coumarins as a new class of biosafe multifunctional therapeutic candidates: A journey from In Vitro to In Silico prediction

  year unknowncites this paper