Geometric Effects Position Renal Vesicles During Kidney Development

During kidney development, reciprocal signalling between the epithelium and the mesenchyme coordinates nephrogenesis with branching morphogenesis of the collecting ducts. The mechanism that positions the renal vesicles, and thus the nephrons, relative to the branching ureteric buds has remained elusive. By combining computational modelling and experiments, we show that geometric effects concentrate the key regulator, WNT9b, at the junctions between parent and daughter branches where renal vesicles emerge, even when uniformly expressed in the ureteric epithelium. This curvature effect might be a general paradigm to create non-uniform signalling in development.

• Publication year

  2023

• Venue

  bioRxiv

• Publication date

  2023-11-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/2022.08.30.505859PMID 38060445
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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