New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: frontiers for new pharmaceutical therapies to lower cardiovascular disease risk.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Canadian Journal of Cardiology

• Publication date

  2011-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.cjca.2010.12.020PMID 21459267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1988cited by this paper
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  1984cited by this paper
• Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.

  1980cited by this paper
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  1978cited by this paper
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  1971cited by this paper
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