Development and validation of a combined ferroptosis- and pyroptosis-related gene signatures for the prediction of clinical outcomes in lung adenocarcinoma.

No abstract is available for this paper.

• Publication year

  2022

• Venue

  American Journal of Cancer Research

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 36119825PMCID PMC9442029
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pyroptosis and pyroptosis-inducing cancer drugs

  2022cited by this paper
• Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma

  2022cited by this paper
• Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons

  2022cited by this paper
• Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer.

  2022cited by this paper
• Ferroptosis: A New Promising Target for Lung Cancer Therapy

  2021cited by this paper
• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

  2021cited by this paper
• Immune Resistance in Lung Adenocarcinoma

  2021cited by this paper
• Mechanisms of Neoantigen-Targeted Induction of Pyroptosis and Ferroptosis: From Basic Research to Clinical Applications

  2021cited by this paper
• Prognostic significance of pyroptosis-related factors in lung adenocarcinoma

  2021cited by this paper
• Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

  2021cited by this paper
• The mechanisms and therapeutic targets of ferroptosis in cancer

  2021cited by this paper
• RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11.

  2021cited by this paper
• Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

  2021cited by this paper
• Ferroptosis: mechanisms, biology and role in disease

  2021cited by this paper
• Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11

  2021cited by this paper
• Identification of the pyroptosis‑related prognostic gene signature and the associated regulation axis in lung adenocarcinoma

  2021cited by this paper
• Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis.

  2021cited by this paper
• Combination of tumor mutation burden and immune infiltrates for the prognosis of lung adenocarcinoma.

  2021cited by this paper
• Ferroptosis: an iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy

  2021cited by this paper
• Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

  2020cited by this paper
• Combination of Immune Checkpoint Inhibitors with Chemotherapy in Lung Cancer

  2020cited by this paper
• Gasdermin E suppresses tumor growth by activating anti-tumor immunity

  2020cited by this paper
• Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis

  2020cited by this paper
• BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining

  2020cited by this paper
• Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

  2020cited by this paper
• CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy

  2019cited by this paper
• The tumor suppressor protein p53 and the ferroptosis network

  2019cited by this paper
• The Role of Metabolic Remodeling in Macrophage Polarization and Its Effect on Skeletal Muscle Regeneration

  2019cited by this paper
• Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

  2019cited by this paper
• Diverging inflammasome signals in tumorigenesis and potential targeting

  2019cited by this paper
• Targeting Ferroptosis to Iron Out Cancer.

  2019cited by this paper
• A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System.

  2019cited by this paper
• The role of pyroptosis in cancer: pro-cancer or pro-“host”?

  2019cited by this paper
• STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.

  2019cited by this paper
• The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis

  2019cited by this paper
• Immune checkpoint inhibitors in cancer therapy: a focus on T‐regulatory cells

  2018cited by this paper
• M1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomas

  2018cited by this paper
• Iron Metabolism in Cancer

  2018cited by this paper
• Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non-small cell lung cancer

  2018cited by this paper
• IFN-&ggr;–related mRNA profile predicts clinical response to PD-1 blockade

  2017cited by this paper
• Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

  2017cited by this paper
• Targeting mutant p53 for efficient cancer therapy

  2017cited by this paper
• NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

  2017cited by this paper
• Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression.

  2016cited by this paper
• Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma.

  2016cited by this paper
• Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

  2016cited by this paper
• Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

  2015cited by this paper
• The non-small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome.

  2015cited by this paper
• Regulation of inflammasome activation

  2015cited by this paper
• Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

  2015cited by this paper
• Caspase substrates and cellular remodeling.

  2011cited by this paper
• The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer

  2011cited by this paper
• Inflammatory Stimuli Regulate Caspase Substrate Profiles*

  2010cited by this paper

• Identification and verification of a combined ferroptosis- and pyroptosis-related signature for a prognostic classifier and immunosuppressive targets in colorectal cancer.

  2025cites this paper
• Prognostic Significance of Systemic Immune-Inflammation Index in Patients with de Novo non‑M3 Acute Myeloid Leukemia

  2025cites this paper
• Ferroptosis in sepsis induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS): a potential therapeutic strategy

  2025cites this paper
• Systematic integration of machine learning algorithms to develop immune escape-related signatures to improve clinical outcomes in lung adenocarcinoma patients

  2023cites this paper