Effect of folate deficiency on placental DNA methylation in hyperhomocysteinemic rats.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Nutritional Biochemistry

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jnutbio.2008.01.010PMID 18547797
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• In utero physiology: role of folic acid in nutrient delivery and fetal development.

  2007cited by this paper
• Determining the global DNA methylation status of rat according to the identifier repetitive elements

  2007cited by this paper
• Folate and human reproduction.

  2006cited by this paper
• Roles for nutrients in epigenetic events.

  2005cited by this paper
• Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia.

  2005cited by this paper
• Inhibition of cephalic neural tube closure by 5-azacytidine in neurulating rat embryos in vitro

  2004cited by this paper
• Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats.

  2004cited by this paper
• Expression of various genes is controlled by DNA methylation during mammalian development

  2003cited by this paper
• Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

  2003cited by this paper
• Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.

  2002influential reference
• Reversed-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in mouse liver and the effect of methionine on their concentrations.

  2001cited by this paper
• Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice.

  2001cited by this paper
• Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy

  2000influential reference
• Folate affects apoptosis in human trophoblastic cells

  2000cited by this paper
• Folate and intrauterine growth retardation

  2000cited by this paper
• Influence of maternal nutrition on outcome of pregnancy: prospective cohort study

  1999cited by this paper
• Homocysteine metabolism.

  1999cited by this paper
• Homocysteine and vascular disease.

  1999cited by this paper
• Blood Folate Level Determined by a Microplate Reader and Folate Intake Measured by a Weighted Food Record

  1999cited by this paper
• Hyperhomocysteinemia - A risk factor for abruptio placentae

  1997cited by this paper
• Elevated Homocyst(e)ine Levels With Preeclampsia

  1997cited by this paper
• Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene.

  1997cited by this paper
• Hyperhomocysteinemia: a risk factor for placental abruption or infarction.

  1996cited by this paper
• Changes of some vitamin levels during and after normal pregnancy.

  1995cited by this paper
• Homocysteine metabolism in pregnancies complicated by neural-tube defects.

  1995cited by this paper
• Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss.

  1993cited by this paper
• Intrauterine growth retardation, perinatal death, and maternal homocysteine levels.

  1992cited by this paper
• Presence of the French Canadian deletion in a French patient with familial hypercholesterolemia.

  1992cited by this paper
• Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.

  1992cited by this paper
• Presence of the French Canadian deletion in a French patient with familial hypercholesterolemia.

  1992cited by this paper
• Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets.

  1989influential reference
• Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection.

  1987cited by this paper

• In vitro exposure to the SARS-CoV-2 Spike protein subunit S1 leads to changes in several functional characteristics of human trophoblast cells.

  2026cites this paper
• Mechanisms of genome instability from cellular folate stress.

  2025cites this paper
• Micro-nutrient sufficiency in mothers and babies: management of deficiencies while avoiding overload during pregnancy

  2025cites this paper
• The epigenetic impact of lifestyle factors on metabolic syndrome: A systematic review

  2025cites this paper
• Metformin and insulin exacerbate one‐carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas

  2025cites this paper
• Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population

  2024cites this paper
• Placenta-Related Parameters at Delivery in Relation to Folic Acid Supplementation in Different Pregnancies

  2024cites this paper
• SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3

  2023cites this paper
• Epigenetic Mechanisms Involved in the Effects of Maternal Hyperhomocysteinemia on the Functional State of Placenta and Nervous System Plasticity in the Offspring

  2023influential citation
• Impact of Methyl-Donor Micronutrient Supplementation on DNA Methylation Patterns: A Systematic Review and Meta-Analysis of in vitro, Animal, and Human Studies

  2023cites this paper
• Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus

  2023cites this paper
• Epigenetic mechanisms of the maternal hyperhomocysteinemia influence on the placenta functional state and the offspring nervous system plasticity

  2023cites this paper
• Homocysteine Metabolism in Pregnancy and Developmental Impacts

  2022cites this paper
• Prenatal epigenetic factors are predisposing for neurodevelopmental disorders—Considering placenta as a model

  2022cites this paper
• Пренатальный стресс при материнской гипергомоцистеинемии: нарушения развития нервной системы плода и функционального состояния плаценты

  2021cites this paper
• Prenatal Stress in Maternal Hyperhomocysteinemia: Impairments in the Fetal Nervous System Development and Placental Function

  2021cites this paper
• Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study

  2021cites this paper
• A narrative review on the role of folate-mediated one-carbon metabolism and its associated gene polymorphisms in posing risk to preeclampsia

  2021cites this paper
• Increased homocysteine mediated oxidative stress as key determinant of hepatitis E virus (HEV) infected pregnancy complication and outcome: A study from Northeast India.

  2021cites this paper
• Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates β-catenin in the Brain of Male Mouse Offspring.

  2021cites this paper
• Folic acid supplementation in the gestational phase of female rats improves age-related memory impairment and neuroinflammation in their adult and aged offspring.

  2020cites this paper
• Neurodevelopment outcomes

  2020cites this paper
• Elimination of human folypolyglutamate synthetase alters programming and plasticity of somatic cells

  2019cites this paper
• Prenatal air pollution and childhood IQ: Preliminary evidence of effect modification by folate.

  2019cites this paper
• One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms

  2019cites this paper
• Micronutrients Intake and Status during Pregnancy and Lactation

  2019influential citation
• Genome-wide DNA methylation changes in placenta tissues associated with small for gestational age newborns; cohort study in the Chinese population.

  2019cites this paper
• Balanced Essential Micronutrients during Pregnancy: High Concern

  2018cites this paper
• The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta

  2018cites this paper
• Maternal Red Blood Cell Folate and Infant Vitamin B12 Status Influence Methylation of Genes Associated with Childhood Acute Lymphoblastic Leukemia

  2018cites this paper
• Transgenerational effects of prenatal restricted diet on gene expression and histone modifications in the rat

  2018cites this paper
• Placental Defects: An Epigenetic Perspective

  2018cites this paper
• Citation: McKay, Jill, Williams, Elizabeth A. and Mathers, John C. (2011) Effect of Maternal and Post-Weaning Folate Supply on Gene-Specific DNA Methylation in the Small Intestine of Weaning and Adult Apc+/Min and Wild

  2018cites this paper
• Effects of micronutrients on placental function: evidence from clinical studies to animal models.

  2018cites this paper
• Targeted metabolomics analysis reveals the association between maternal folic acid supplementation and fatty acids and amino acids profiles in rat pups.

  2018cites this paper
• Homocysteine activates autophagy by inhibition of CFTR expression via interaction between DNA methylation and H3K27me3 in mouse liver

  2018cites this paper
• Associative role of TYMS6bpdel polymorphism and resulting hyperhomocysteinemia in the pathogenesis of preterm delivery and associated complications: A study from Northeast India.

  2017cites this paper
• Endocrine-disrupting chemicals and fatty liver disease

  2017cites this paper
• Maternal vitamin D, DNA methylation at imprint regulatory regions, and offspring weight at birth, 1 year, and 3 years

  2017cites this paper
• Analysis of genome instability biomarkers in children with non-syndromic orofacial clefts

  2017cites this paper
• Neurotrophic Factors and Maternal Nutrition During Pregnancy.

  2017cites this paper
• 7 DNA Methylation in Development

  2017cites this paper
• Maternal Vitamin B Deficiency and Epigenetic Changes of Genes Involved in the Alzheimerâ s Disease Pathogenesis

  2017cites this paper
• Effects of maternal folic acid supplementation on gene methylation and being small for gestational age.

  2016cites this paper
• The Effect of Paternal Folic Acid Supplementation on Folate Concentrations and DNA Methylation of the Offspring in a Mouse Model

  2016cites this paper
• The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming

  2016cites this paper
• Effect of Maternal and Paternal Nutrition on DNA Methylation in the Offspring: A Systematic Review of Human and Animal Studies

  2016cites this paper
• Effects of Stress Throughout the Lifespan on the Brain and Behavior

  2016cites this paper
• Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes

  2015cites this paper
• The role of active vitamin B12 (holotranscobalamin) in the development of anemia of pregnancy

  2015cites this paper
• Folic Acid Supplementation during Pregnancy Induces Sex-Specific Changes in Methylation and Expression of Placental 11β-Hydroxysteroid Dehydrogenase 2 in Rats

  2015cites this paper
• Proposing interactions between maternal phospholipids and the one carbon cycle: A novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life.

  2015cites this paper
• DNA Methylation:: An Epigenetic Marker of Breast Cancer Influenced by Nutrients Acting as an Environmental Factor

  2015cites this paper
• From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

  2015cites this paper
• Folic Acid Uptake and Its Regulation in the Placenta

  2015cites this paper
• Methylation and Atherosclerosis

  2015cites this paper
• Interaction of Polyphenols with the Intestinal and Placental Absorption of some Nutrients and other Compounds

  2014cites this paper
• Inflammation, advancing age and nutrition

  2014cites this paper
• Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet.

  2014cites this paper
• Connecting Phytochemicals, Epigenetics, and Healthy Aging

  2014cites this paper
• Effect of Vitamin B Deprivation during Pregnancy and Lactation on Homocysteine Metabolism and Related Metabolites in Brain and Plasma of Mice Offspring

  2014cites this paper
• Transcriptomic modifications and epigenetic control induced by a hypercaloric diet and the supplementation with methyl donors: perinatal effects and during adult life

  2013cites this paper
• DOES FOLIC ACID SUPPLEMENTATION PREVENT NICOTINE-INDUCED BETA CELL DYSFUNCTION?

  2013cites this paper
• Lessons from the one-carbon metabolism: passing it along to the next generation.

  2013cites this paper
• Epigenetic alterations in folate transport genes in placental tissue from fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia

  2013cites this paper
• Estimativa de folato na dieta de gestantes: o papel da fortificação de farinhas e do suplemento dietético

  2013cites this paper
• Metabolic alterations induced by high maternal BMI and gestational diabetes in maternal, placental and neonatal outcomes

  2013cites this paper
• Study on the Dietary Factors of Esophageal Cancer

  2012cites this paper
• Embryology - Updates and Highlights on Classic Topics

  2012cites this paper
• Folate and DNA Methylation

  2012cites this paper
• DNA methylation in development

  2012cites this paper
• Esophageal Cancer - Cell and Molecular Biology, Biomarkers, Nutrition and Treatment

  2012influential citation
• Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes.

  2012cites this paper
• Diet, epigenetics, and cancer.

  2012cites this paper
• Folic Acid Transport to the Human Fetus Is Decreased in Pregnancies with Chronic Alcohol Exposure

  2012cites this paper
• Blood as a surrogate marker for tissue-specific DNA methylation and changes due to folate depletion in post-partum female mice.

  2011cites this paper
• Sheep as an experimental model for human ART: novel insights on phenotypic alterations in ART-derived sheep conceptuses.

  2011cites this paper
• Phytochemicals and Cancer Chemoprevention: Epigenetic Friends or Foe?

  2011cites this paper
• Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects.

  2011cites this paper
• Nutritional influences on epigenetics and age-related disease

  2011influential citation
• Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut.

  2011cites this paper
• Diet induced epigenetic changes and their implications for health

  2011cites this paper
• Effect of Maternal and Post-Weaning Folate Supply on Gene-Specific DNA Methylation in the Small Intestine of Weaning and Adult Apc+/Min and Wild Type Mice

  2011influential citation
• Epigenetics and lifestyle.

  2011cites this paper
• Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring

  2011cites this paper
• Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats

  2011cites this paper
• Effect of paternal folate deficiency on placental folate content and folate receptor α expression in rats

  2011cites this paper
• Homocysteine is transported by the microvillous plasma membrane of human placenta

  2011cites this paper
• DNA Methylation and Essential Hypertension: A Review*: DNA Methylation and Essential Hypertension: A Review*

  2010cites this paper
• Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders.

  2010cites this paper
• Perinatal folate supply: relevance in health outcome parameters.

  2010cites this paper
• Effects of Dietary Folic Acid on the Expression of Myelin Basic Protein in the Brain and Spinal Cord of Pregnant and Lactating Rats

  2010cites this paper
• Expression of folate transporters in human placenta and implications for homocysteine metabolism.

  2010cites this paper
• Nutrition, Epigenetic Mechanisms, And Human Disease

  2010cites this paper
• REVIEWS: CURRENT TOPICS DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging ☆

  2009cites this paper
• DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging.

  2009cites this paper
• Nephrogenesis in malnutrition

  year unknowncites this paper