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The association between air pollutants, meteorological factors and tuberculosis cases in Beijing, China: A seven-year time series study.

Shan-hua Sun,Qinxue Chang,Junyu He,Xianyu Wei,Hailong Sun,Yuan-yong Xu,R. S. Soares Magalhães,Yuming Guo,Z. Cui,Wenyi Zhang

Published 2022 in Environmental Research

ABSTRACT

BACKGROUND Tuberculosis (TB) is a severe public health problem globally. Previous studies have revealed insufficient and inconsistent associations between air pollutants, meteorological factors and TB cases. Yet few studies have examined the associations between air pollutants, meteorological factors and TB cases in Beijing. OBJECTIVE The purpose of this study was to explore the impact of air pollutants and meteorological factors on TB in Beijing, and to provide novel insights into public health managers to formulate control strategies of TB in Beijing. METHODS Data on the daily case of TB in Beijing during 2014-2020 were obtained from Chinese tuberculosis information management system. Concurrent data on the daily PM10, PM2.5, SO2, NO2, CO and O3, were obtained from the online publication platform of the Chinese National Environmental Monitoring Center. Daily average temperature, average wind speed, relative humidity, sunshine duration and total precipitation were collected from the China Meteorological Science Data Sharing Service System. A distributed lag non-linear model was fitted to identify the non-linear exposure-response relationship and the lag effects between air pollution, meteorological factor exposures and TB cases in Beijing. RESULTS In the single-factor model, the excess risk (ER) of TB was significantly positively associated with every 10 μg/m3 increase in NO2 in lag 1 week (ER: 1.3%; 95% confidence interval [CI]: 0.4%, 2.3%) and every 0.1 m/s increase in average wind speed in lag 5 weeks (ER: 0.3%; 95% CI: 0.1%, 0.5%), and was negatively associated with every 10 μg/m3 increase in O3 in lag 1 week (ER: 1.2%; 95% CI: 1.8%, -0.5%), every 5 °C increase in average temperature (ER: 1.7%; 95% CI: 2.9%, -0.4%) and every 10% increase in average relative humidity (ER: 0.4%; 95% CI: 0.8%, -0.1%) in lag 10 weeks, respectively. In the multi-factor model, the lag effects between TB cases and air pollutants, meteorological factors were similar. The subgroup analysis suggests that the effects of NO2, O3, average wind speed and relative humidity on TB were greater in male or labor age subgroup, while the effect of CO was greater in the elderly. In addition, no significant associations were found between PM2.5, SO2, sunshine duration and TB cases. CONCLUSION Our findings provide a better understanding of air pollutants and meteorological factors driving tuberculosis occurrence in Beijing, which enhances the capacity of public health manager to target early warning and disease control policy-making.

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