Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Genetics

• Publication date

  2017-12-11

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1534/genetics.117.300422PMID 29233811PMCID PMC5788528
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cryptococcal dissemination to the central nervous system requires the vacuolar calcium transporter Pmc1

  2018cited by this paper
• Calcium Signaling and Transcriptional Regulation in Cardiomyocytes.

  2017cited by this paper
• Pheromone independent unisexual development in Cryptococcus neoformans

  2017cited by this paper
• Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans

  2017influential reference
• The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism.

  2017cited by this paper
• Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.

  2017cited by this paper
• The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases

  2016cited by this paper
• Cryptococcal therapies and drug targets: the old, the new and the promising

  2016cited by this paper
• Calcineurin Targets Involved in Stress Survival and Fungal Virulence

  2016influential reference
• Conserved and Diverged Functions of the Calcineurin-Activated Prz1 Transcription Factor in Fission Yeast

  2016cited by this paper
• Puf4 Regulates both Splicing and Decay of HXL1 mRNA Encoding the Unfolded Protein Response Transcription Factor in Cryptococcus neoformans

  2015influential reference
• Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host–pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides

  2015cited by this paper
• Calcineurin and glial signaling: neuroinflammation and beyond

  2014cited by this paper
• Calcineurin Controls Hyphal Growth, Virulence, and Drug Tolerance of Candida tropicalis

  2014cited by this paper
• Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides

  2013cited by this paper
• Genetic Circuits that Govern Bisexual and Unisexual Reproduction in Cryptococcus neoformans

  2013cited by this paper
• Unisexual and Heterosexual Meiotic Reproduction Generate Aneuploidy and Phenotypic Diversity De Novo in the Yeast Cryptococcus neoformans

  2013cited by this paper
• The CRZ1/SP1-like gene links survival under limited aeration, cell integrity and biofilm formation in the pathogenic yeast Cryptococcus neoformans.

  2013cited by this paper
• Congenic Strains of the Filamentous Form of Cryptococcus neoformans for Studies of Fungal Morphogenesis and Virulence

  2013cited by this paper
• The calcium transporter Pmc1 provides Ca2+ tolerance and influences the progression of murine cryptococcal infection

  2013cited by this paper
• Calcineurin Is Required for Pseudohyphal Growth, Virulence, and Drug Resistance in Candida lusitaniae

  2012cited by this paper
• The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

  2012cited by this paper
• Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata

  2012cited by this paper
• The Crz1/Sp1 Transcription Factor of Cryptococcus neoformans Is Activated by Calcineurin and Regulates Cell Wall Integrity

  2012cited by this paper
• Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus

  2011cited by this paper
• FungiDB: an integrated functional genomics database for fungi

  2011influential reference
• Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

  2011cited by this paper
• Calcineurin Controls Drug Tolerance, Hyphal Growth, and Virulence in Candida dubliniensis

  2011cited by this paper
• The C2 Domain Protein Cts1 Functions in the Calcineurin Signaling Circuit during High-Temperature Stress Responses in Cryptococcus neoformans

  2011cited by this paper
• A Tetrad Analysis of the Basidiomycete Fungus Cryptococcus neoformans

  2010cited by this paper
• The Vacuolar Ca2+ Exchanger Vcx1 Is Involved in Calcineurin-Dependent Ca2+ Tolerance and Virulence in Cryptococcus neoformans

  2010cited by this paper
• Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA

  2010cited by this paper
• Combining ChIP-chip and Expression Profiling to Model the MoCRZ1 Mediated Circuit for Ca2+/Calcineurin Signaling in the Rice Blast Fungus

  2010cited by this paper
• Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

  2009cited by this paper
• Signalling pathways in the pathogenesis of Cryptococcus

  2009cited by this paper
• Ca2+/calmodulin‐dependent transcriptional pathways: potential mediators of skeletal muscle growth and development

  2009cited by this paper
• Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

  2008cited by this paper
• Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections

  2007cited by this paper
• Virulence Attributes and Hyphal Growth of C. neoformans Are Quantitative Traits and the MATα Allele Enhances Filamentation

  2006influential reference
• Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

  2006cited by this paper
• CRZ1, a target of the calcineurin pathway in Candida albicans

  2006cited by this paper
• Calcineurin-Binding Protein Cbp1 Directs the Specificity of Calcineurin-Dependent Hyphal Elongation during Mating in Cryptococcus neoformans

  2005cited by this paper
• Sexual reproduction between partners of the same mating type in Cryptococcus neoformans

  2005influential reference
• Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

  2005cited by this paper
• Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor

  2005cited by this paper
• Calcineurin Is Required for Candida albicans To Survive Calcium Stress in Serum

  2005cited by this paper
• Identification of Factors Regulating Poly(A) Tail Synthesis and Maturation

  2004cited by this paper
• The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans

  2004cited by this paper
• Posttranscriptional Regulation of HO Expression by the Mkt1-Pbp1 Complex

  2004cited by this paper
• Calcineurin: a central controller of signalling in eukaryotes

  2004cited by this paper
• In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus

  2004cited by this paper
• Extensive Association of Functionally and Cytotopically Related mRNAs with Puf Family RNA-Binding Proteins in Yeast

  2004cited by this paper
• Calcineurin Is Essential for Virulence in Candida albicans

  2003cited by this paper
• Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates

  2003cited by this paper
• Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.

  2003cited by this paper
• Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence

  2003cited by this paper
• Phospholipid-Binding Protein Cts1 Controls Septation and Functions Coordinately with Calcineurin in Cryptococcus neoformans

  2003influential reference
• Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.

  2003cited by this paper
• Calcineurin Is Essential for Candida albicans Survival in Serum and Virulence

  2003cited by this paper
• Genome-wide Analysis of Gene Expression Regulated by the Calcineurin/Crz1p Signaling Pathway in Saccharomyces cerevisiae *

  2002cited by this paper
• Calcineurin phosphatase in signal transduction: lessons from fission yeast

  2002cited by this paper
• A PCR-based strategy to generate integrative targeting alleles with large regions of homology.

  2002cited by this paper
• Calcineurin is essential for survival during membrane stress in Candida albicans

  2002cited by this paper
• Good fungi gone bad: The corruption of calcineurin

  2002cited by this paper
• Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans

  2001influential reference
• Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in Cryptococcus neoformans

  2001cited by this paper
• Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

  2000cited by this paper
• Comparison of the Roles of Calcineurin in Physiology and Virulence in Serotype D and Serotype A Strains ofCryptococcus neoformans

  2000cited by this paper
• Fluconazole plus Cyclosporine: a Fungicidal Combination Effective against Experimental Endocarditis Due to Candida albicans

  2000cited by this paper
• Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.

  1999cited by this paper
• Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae.

  1997cited by this paper
• Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast.

  1997cited by this paper
• Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

  1997cited by this paper
• Calcineurin is required for virulence of Cryptococcus neoformans

  1997influential reference
• Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae

  1996cited by this paper
• The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF‐4B, have RNA annealing activity.

  1995cited by this paper
• NF-AT components define a family of transcription factors targeted in T-cell activation

  1994cited by this paper
• Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA

  1993cited by this paper
• Genetic association of mating types and virulence in Cryptococcus neoformans

  1992cited by this paper
• Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

  1992cited by this paper
• Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

  1991cited by this paper
• TheSaccharomyces cerevisiae genes (CMP1 andCMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B

  1991cited by this paper
• Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

  1991cited by this paper
• Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

  1991cited by this paper
• Calcofluor white alters the assembly of chitin fibrils in Saccharomyces cerevisiae and Candida albicans cells.

  1983cited by this paper
• Discovery of A Ca2+‐and calmodulin‐dependent protein phosphatase

  1982cited by this paper
• Use of Congo red-polysaccharide interactions in enumeration and characterization of cellulolytic bacteria from the bovine rumen

  1982cited by this paper
• Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

  1979influential reference
• Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans.

  1976cited by this paper
• Serveur Académique Lausannois SERVAL serval.unil.ch

  year unknowncited by this paper

• Inhibition of respiration prompts commitment to unisexual reproduction in Cryptococcus deneoformans.

  2025cites this paper
• The pre-mRNA splicing modulator pladienolide B inhibits Cryptococcus neoformans germination and growth

  2025cites this paper
• Myostatin promotes proliferation of bovine muscle satellite cells through activating TRPC4/Ca2+/Calcineurin/NFATc3 pathway

  2024cites this paper
• Roles of Different Signaling Pathways in Cryptococcus neoformans Virulence

  2024cites this paper
• Loss of the putative Rab GTPase, Ypt7, impairs the virulence of Cryptococcus neoformans

  2024cites this paper
• Combating increased antifungal drug resistance in Cryptococcus, what should we do in the future?

  2023cites this paper
• Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi

  2023cites this paper
• TFEB: a double-edged sword for tumor metastasis

  2023cites this paper
• Tacrolimus inhibits stress responses and hyphal formation via the calcineurin signaling pathway in Trichosporon asahii

  2022cites this paper
• A Velvet Transcription Factor Specifically Activates Mating through a Novel Mating-Responsive Protein in the Human Fungal Pathogen Cryptococcus deneoformans

  2022cites this paper
• Nanosheet-Facilitated Spray Delivery of dsRNAs Represents a Potential Tool to Control Rhizoctonia solani Infection

  2022cites this paper
• A critical role of calcineurin in stress responses, hyphal formation, and virulence of the pathogenic fungus Trichosporon asahii

  2022cites this paper
• Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen

  2022cites this paper
• Transcription Factor Crz1 from Cryptococcus humicola Conferred Aluminum Resistance and Interacted with Calcineurin

  2022cites this paper
• Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome

  2021cites this paper
• Cryptococcus neoformans: Sex, morphogenesis, and virulence.

  2021cites this paper
• HOG1 has an essential role in the stress response, virulence and pathogenicity of Cryptococcus gattii

  2021cites this paper
• Calcium: a central player in Cryptococcus biology

  2021cites this paper
• Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans

  2021cites this paper
• The monothiol glutaredoxin Grx4 influences thermotolerance, cell wall integrity, and Mpk1 signaling in Cryptococcus neoformans

  2021cites this paper
• Interplay of Protein Phosphatases with Cytoskeleton Signaling in Response to Stress Factors in Plants

  2020cites this paper
• Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans

  2020cites this paper
• RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans

  2020cites this paper
• Ser/Thr protein phosphatases in fungi: structure, regulation and function

  2019cites this paper
• Life Cycle of Cryptococcus neoformans.

  2019cites this paper
• Transient receptor potential vanilloid 4 is a critical mediator in LPS mediated inflammation by mediating calcineurin/NFATc3 signaling.

  2019cites this paper
• The Cys2His2 zinc finger protein Zfp1 regulates sexual reproduction and virulence in Cryptococcus neoformans.

  2019cites this paper
• Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans

  2019cites this paper
• Pbp1-Interacting Protein Mkt1 Regulates Virulence and Sexual Reproduction in Cryptococcus neoformans

  2019cites this paper
• Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens.

  2019cites this paper