Cancer risk associated with alpha-1-antitrypsin deficiency: only large registries will give us the answer

Alpha-1-antitrypsin (AAT) is a serine proteinase inhibitor, the main function of which is to inhibit neutrophil elastase (NE) activity, but it also regulates several immune and inflammatory responses [1]. Deficiency of the protein (alpha-1-antitrypsin deficiency or AATD) is a well-known genetic condition associated with an increased risk of developing pulmonary emphysema and liver disease [2, 3]. It has been hypothesised that it is associated with other respiratory diseases, such as asthma or bronchiectasis [4], and it has also been linked with a potential increase of the risk of some types of cancer, although the information available is sparse [5]. Alpha-1-antitrypsin deficiency has been linked with a potential increase of the risk of some types of cancer; international prospective registries are key to shed light on this important aspect https://bit.ly/3AIApov

• Publication year

  2022

• Venue

  European Respiratory Journal

• Publication date

  2022-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1183/13993003.01289-2022PMID 36302522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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