SCIENCE@home

Peripheral Blood Monocyte Abundance Predicts Outcomes in Patients with Breast Cancer

M. Axelrod,Yu Wang,Yaomin Xu,Xiaopeng Sun,C. Bejan,P. Gonzalez-Ericsson,S. Nunnery,Riley E. Bergman,J. Donaldson,A. Guerrero-Zotano,C. Massa,B. Seliger,M. Sanders,I. Mayer,J. Balko

Published 2022 in Cancer Research Communications

ABSTRACT

Biomarkers of response are needed in breast cancer to stratify patients to appropriate therapies and avoid unnecessary toxicity. We used peripheral blood gene expression and cell-type abundance to identify biomarkers of response and recurrence in neoadjuvant chemotherapy–treated patients with breast cancer. We identified a signature of IFN and complement response that was higher in the blood of patients with pathologic complete response. This signature was preferentially expressed by monocytes in single-cell RNA sequencing. Monocytes are routinely measured clinically, enabling examination of clinically measured monocytes in multiple independent cohorts. We found that peripheral monocytes were higher in patients with good outcomes in four cohorts of patients with breast cancer. Blood gene expression and cell type abundance biomarkers may be useful for prognostication in breast cancer. Significance: Biomarkers are needed in breast cancer to identify patients at risk for recurrence. Blood is an attractive site for biomarker identification due to the relative ease of longitudinal sampling. Our study suggests that blood-based gene expression and cell-type abundance biomarkers may have clinical utility in breast cancer.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-29 of 29 references · Page 1 of 1

CITED BY

Showing 1-9 of 9 citing papers · Page 1 of 1