Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Protein & Cell

• Publication date

  2011-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s13238-011-1049-7PMID 21637962PMCID PMC4875338
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mouse Rad1 deletion enhances susceptibility for skin tumor development

  2010cited by this paper
• Rad9 Is Required for B Cell Proliferation and Immunoglobulin Class Switch Recombination*

  2010cited by this paper
• Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation.

  2009cited by this paper
• Crystal structure of the human rad9-hus1-rad1 clamp.

  2009cited by this paper
• Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint Complex*

  2009cited by this paper
• Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration

  2009cited by this paper
• The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining

  2008cited by this paper
• Human Embryonic Stem Cells Have Enhanced Repair of Multiple Forms of DNA Damage

  2008cited by this paper
• DNA repair in murine embryonic stem cells and differentiated cells.

  2008cited by this paper
• Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development.

  2008cited by this paper
• Genome Maintenance Defects in Cultured Cells and Mice following Partial Inactivation of the Essential Cell Cycle Checkpoint Gene Hus1

  2007cited by this paper
• Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene.

  2005cited by this paper
• Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality

  2004cited by this paper
• Disruption of the Rad9/Rad1/Hus1 (9–1–1) complex leads to checkpoint signaling and replication defects

  2004influential reference
• Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.

  2004cited by this paper
• Analysis of the mammalian cell cycle by flow cytometry.

  2004influential reference
• Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex.

  2004cited by this paper
• Critical Role for Mouse Hus1 in an S-Phase DNA Damage Cell Cycle Checkpoint

  2003influential reference
• Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

  2003cited by this paper
• Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

  2003cited by this paper
• Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9‐1‐1 and Rad17‐RFC

  2002cited by this paper
• Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) Chromatin Association Is an Early Checkpoint Signaling Event*

  2002cited by this paper
• Purification and characterization of human DNA damage checkpoint Rad complexes

  2001cited by this paper
• Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.

  2001influential reference
• Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex*

  2001influential reference
• The Human Checkpoint Protein hRad17 Interacts with the PCNA-like Proteins hRad1, hHus1, and hRad9*

  2000cited by this paper
• Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression.

  2000cited by this paper
• Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress.

  2000influential reference
• HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene.

  1998influential reference
• A Human Homologue of the Schizosaccharomyces pombe rad1 + Checkpoint Gene Encodes an Exonuclease*

  1998cited by this paper
• Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.

  1998influential reference
• ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage.

  1998cited by this paper
• G2 / M checkpoint genes of Saccharomyces cerevisiae : further evidence for roles in DNA replication and / or repair

  1997cited by this paper
• The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

  1997cited by this paper
• A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage.

  1995cited by this paper
• Checkpoint controls in Schizosaccharomyces pombe: rad1.

  1992influential reference
• Molecular cloning and analysis of Schizosaccharomyces pombe rad9, a gene involved in DNA repair and mutagenesis

  1992influential reference
• DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

  1992influential reference
• Fission yeast genes involved in coupling mitosis to completion of DNA replication.

  1992influential reference
• Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe

  1991influential reference
• Checkpoints: controls that ensure the order of cell cycle events.

  1989cited by this paper

• Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia

  2023cites this paper
• Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC).

  2020cites this paper
• ArticleRadiation Response of Murine Embryonic Stem CellsChristine E. Hellweg 1**

  2020cites this paper
• Radiation Response of Murine Embryonic Stem Cells

  2020cites this paper
• Alternative Splicing of OsRAD1 Defines C-Terminal Domain Essential for Protein Function in Meiosis

  2020cites this paper
• Novel Cellular Activities of The Cell Cycle Checkpoint Protein Rad1 Revealed by a New High-quality anti-Rad1 Antibody

  2016cites this paper
• The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues

  2015cites this paper
• ATM, BRCA1, and Aurora A: Mechanisms of G2/M Checkpoint Control in Human Embryonic Stem Cells

  2014cites this paper
• Effect of DNA repair deficiencies on the cytotoxicity of drugs used in cancer therapy - a review.

  2014cites this paper
• Computer System for Analysis of Molecular Evolution Modes (SAMEM): Analysis of molecular evolution modes at deep inner branches of the phylogenetic tree

  2012cites this paper
• Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis

  2012cites this paper
• Effects of Simulated Microgravity on Embryonic Stem Cells

  2011influential citation