Mitochondrial GPAT-derived LPA controls auxin-dependent embryonic and postembryonic development

Significance Lysophosphatidic acid (LPA) is an anionic bioactive phospholipid. In this study, we explored whether and how LPA signaling impacts plant growth and development and discovered that LPA-controlled membrane properties modulate the PIN-FORMED1 (PIN1) auxin efflux transporter, which is linked to the plasma membrane and polar auxin transport in plants. Our findings reveal a fundamental role of lipid metabolism in controlling embryonic and postembryonic development, as well as mechanistically interconnecting membrane LPA and PIN1 in the fine-tuned regulation of auxin signaling.

• Publication year

  2022

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2022-12-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1073/pnas.2212881119PMID 36454754PMCID 9894262
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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