Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1

Inhibitory phosphorylation of Cdh1 by CDK and Polo kinase has been proposed to inactivate APC-Cdh1. Through an exact gene replacement approach, we find CDK, but not Polo, phosphorylation of Cdh1 to be a critical regulatory mechanism. APC-Cdh1 inhibits multiple aspects of spindle morphogenesis, and its activity is modulated by endogenous ACM1.

• Publication year

  2010

• Venue

  Molecular Biology of the Cell

• Publication date

  2010-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E09-10-0901PMID 20089834PMCID 2836972
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008influential reference
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  2006influential reference
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  2002influential reference
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  2002cited by this paper
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  2002influential reference
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  2001influential reference
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  2001influential reference
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  1999cited by this paper
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  1999cited by this paper
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  1998influential reference
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  1998cited by this paper
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  1997influential reference
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1993influential reference
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  1992cited by this paper
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  1986cited by this paper

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  2016influential citation
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