Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Structure

• Publication date

  1998-03-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0969-2126(98)00036-7PMID 9551555
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Purification and Characterization of Bacillus subtilis PyrR, a Bifunctional pyr mRNA-binding Attenuation Protein/Uracil Phosphoribosyltransferase*

  1998cited by this paper
• Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli

  1998cited by this paper
• From genetic to structural characterization of a new class of RNA‐binding domain within the SacY/BglG family of antiterminator proteins

  1997influential reference
• Crystal structure of Escherichia coli xanthine phosphoribosyltransferase.

  1997influential reference
• [27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

  1997cited by this paper
• Interaction of Bacillus subtilis purine repressor with DNA

  1997cited by this paper
• Crystal structure of a new RNA‐binding domain from the antiterminator protein SacY of Bacillus subtilis

  1997influential reference
• A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.

  1997cited by this paper
• Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides.

  1997cited by this paper
• Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.

  1997cited by this paper
• Structure and expression of a pyrimidine gene cluster from the extreme thermophile Thermus strain ZO5

  1997cited by this paper
• Mutations in Bacillus subtilis PyrR, the pyr regulatory protein, with defects in regulation by pyrimidines.

  1996cited by this paper
• Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.

  1996cited by this paper
• Sequence analysis and identification of the pyrKDbF operon from Lactococcus lactis including a novel gene, pyrK, involved in pyrimidine biosynthesis

  1996cited by this paper
• An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae.

  1996cited by this paper
• Function of RNA secondary structures in transcriptional attenuation of the Bacillus subtilis pyr operon.

  1996cited by this paper
• Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop

  1996influential reference
• Characterization of cis-acting mutations in the first attenuator region of the Bacillus subtilis pyr operon that are defective in pyrimidine-mediated regulation of expression

  1996cited by this paper
• Different oligomeric states are involved in the allosteric behavior of uracil phosphoribosyltransferase from Escherichia coli.

  1996cited by this paper
• Transcriptional attenuation of the Bacillus subtilis pyr operon by the PyrR regulatory protein and uridine nucleotides in vitro

  1996cited by this paper
• Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.

  1996cited by this paper
• Structure and Function of the Glutamine Phosphoribosylpyrophosphate Amidotransferase Glutamine Site and Communication with the Phosphoribosylpyrophosphate Site*

  1996cited by this paper
• A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase.

  1996influential reference
• Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.

  1996cited by this paper
• Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.

  1995cited by this paper
• The structure of trp RNA-binding attenuation protein

  1995cited by this paper
• Structure determination of OppA at 2.3 A resolution using multiple-wavelength anomalous dispersion methods.

  1995cited by this paper
• Copyright � 1995, American Society for Microbiology Generation of Auxotrophic Mutants of Enterococcus faecalis

  1995cited by this paper
• Difference refinement: obtaining differences between two related structures.

  1995cited by this paper
• Two genes encoding uracil phosphoribosyltransferase are present in Bacillus subtilis

  1995cited by this paper
• Protein–protein interaction at crystal contacts

  1995cited by this paper
• Roles of the three transcriptional attenuators of the Bacillus subtilis pyrimidine biosynthetic operon in the regulation of its expression

  1995cited by this paper
• The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.

  1995cited by this paper
• Identification of the Bacillus subtilis pur operon repressor.

  1995cited by this paper
• Protein-RNA recognition.

  1995cited by this paper
• Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome.

  1995cited by this paper
• Molecular characterization of pyrimidine biosynthesis genes from the thermophile Bacillus caldolyticus.

  1994cited by this paper
• Structure of the allosteric regulatory enzyme of purine biosynthesis.

  1994cited by this paper
• Crystal structure of orotate phosphoribosyltransferase.

  1994influential reference
• Regulation of the Bacillus subtilis trp operon by an RNA‐binding protein

  1994cited by this paper
• Conserved structures and diversity of functions of RNA-binding proteins.

  1994cited by this paper
• AMoRe: an automated package for molecular replacement

  1994cited by this paper
• Three-dimensional structure of a hammerhead ribozyme

  1994cited by this paper
• Crystal structure of an RNA bacteriophage coat protein–operator complex

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Search designs for protein crystallization based on orthogonal arrays.

  1994cited by this paper
• The pyrimidine biosynthesis operon of the thermophile Bacillus caldolyticus includes genes for uracil phosphoribosyltransferase and uracil permease

  1994cited by this paper
• Regulation of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster by an autogenous transcriptional attenuation mechanism

  1994cited by this paper
• The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

  1994influential reference
• MtrB from Bacillus subtilis binds specifically to trp leader RNA in a tryptophan-dependent manner.

  1993cited by this paper
• Antibody-antigen interactions

  1993cited by this paper
• ALSCRIPT: a tool to format multiple sequence alignments.

  1993cited by this paper
• Reconstitution of Bacillus subtilis trp attenuation in vitro with TRAP, the trp RNA-binding attenuation protein.

  1993cited by this paper
• X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

  1992cited by this paper
• Specificity determinants and structural features in the RNA target of the bacterial antiterminator proteins of the BglG/SacY family.

  1992cited by this paper
• Modulation of the dimerization of a transcriptional antiterminator protein by phosphorylation.

  1992cited by this paper
• Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops.

  1991cited by this paper
• Sparse matrix sampling: a screening method for crystallization of proteins

  1991cited by this paper
• Structural aspects of metal liganding to functional groups in proteins.

  1991cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Ligand binding: proteinase-protein inhibitor interactions

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• Transcriptional antitermination in the bgl operon of E. coli is modulated by a specific RNA binding protein.

  1990cited by this paper
• The structure of protein-protein recognition sites.

  1990cited by this paper
• Mounting of crystals for macromolecular crystallography in a free-standing thin film

  1990cited by this paper
• Induction of levansucrase in Bacillus subtilis: an antitermination mechanism negatively controlled by the phosphotransferase system

  1990cited by this paper
• The sacT gene regulating the sacPA operon in Bacillus subtilis shares strong homology with transcriptional antiterminators

  1990cited by this paper
• Antibody-antigen complexes.

  1988cited by this paper
• Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

  1981cited by this paper
• On the treatment of negative intensity observations

  1978cited by this paper

• Pyrimidine sufficiency is required for Sae two-component system signaling in Staphylococcus aureus

  2025cites this paper
• A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism

  2025cites this paper
• Pyrimidine sufficiency is required for Sae two-component system signaling in Staphylococcus aureus

  2025cites this paper
• Functions of small RNAs in Lactobacillus casei-Pediococcus group of lactic acid bacteria using fragment analysis.

  2020cites this paper
• Posttranscription Initiation Control of Gene Expression Mediated by Bacterial RNA-Binding Proteins.

  2019cites this paper
• The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence

  2018cites this paper
• The Transcriptional landscape of Streptococcus pneumoniae reveals a complex operon architecture and abundant riboregulation critical for growth and virulence

  2018cites this paper
• The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity

  2018cites this paper
• Spontaneous non-canonical assembly of CcmK hexameric components from β-carboxysome shells of cyanobacteria

  2017cites this paper
• Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements

  2017cites this paper
• Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance

  2016cites this paper
• Structure and mapping of spontaneous mutational sites of PyrR from Mycobacterium tuberculosis.

  2016cites this paper
• Symmetry-adapted digital modeling I. Axial symmetric proteins.

  2016cites this paper
• Trigger Enzymes: Coordination of Metabolism and Virulence Gene Expression

  2015cites this paper
• Allosteric Regulation of the First Enzyme in Histidine Biosynthesis

  2015cites this paper
• Evolution of oligomeric state through allosteric pathways that mimic ligand binding

  2014cites this paper
• Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT

  2013cites this paper
• PRTFDC1 Is a Genetic Modifier of HPRT-Deficiency in the Mouse

  2011cites this paper
• Identification of novel non-coding small RNAs from Streptococcus pneumoniae TIGR4 using high-resolution genome tiling arrays

  2010cites this paper
• Tunnels and Intermediates in the Glutamine-Dependent Amidotransferases

  2010cites this paper
• Uracil salvage is necessary for early Arabidopsis development.

  2009cites this paper
• Regulation of Pyrimidine Biosynthetic Gene Expression in Bacteria: Repression without Repressors

  2008cites this paper
• pyr RNA binding to the Bacillus caldolyticus PyrR attenuation protein – characterization and regulation by uridine and guanosine nucleotides

  2008cites this paper
• Expression, purification and preliminary X-ray diffraction studies of the transcriptional factor PyrR from Bacillus halodurans.

  2008cites this paper
• The JMJD2 members of histone demethylase revisited

  2008cites this paper
• Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression

  2007cites this paper
• Structural insights into histone demethylation by JMJD2 family members.

  2006cites this paper
• Expression of the pyr Operon of Lactobacillus plantarum Is Regulated by Inorganic Carbon Availability through a Second Regulator, PyrR2, Homologous to the Pyrimidine-Dependent Regulator PyrR1

  2006cites this paper
• Uracil Salvage Pathway in Lactobacillus plantarum: Transcription and Genetic Studies

  2006cites this paper
• Metabolic enzymes that bind RNA: yet another level of cellular regulatory network?

  2006influential citation
• Crystal structure of a predicted phosphoribosyltransferase (TT1426) from Thermus thermophilus HB8 at 2.01 Å resolution

  2005cites this paper
• Repression of the pyr Operon in Lactobacillus plantarum Prevents Its Ability To Grow at Low Carbon Dioxide Levels

  2005cites this paper
• Strongly correlated structure of axial-symmetric proteins. I. Orthorhombic, tetragonal, trigonal and hexagonal symmetries.

  2005cites this paper
• Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: a persistence gene and protein drug target.

  2005cites this paper
• Structure of the Nucleotide Complex of PyrR, the pyr Attenuation Protein from Bacillus caldolyticus, Suggests Dual Regulation by Pyrimidine and Purine Nucleotides

  2005influential citation
• Structural bioinformatic approaches to the discovery of new antimycobacterial drugs.

  2004cites this paper
• Crystal structure of activated HutP; an RNA binding protein that regulates transcription of the hut operon in Bacillus subtilis.

  2004cites this paper
• Crystallization and preliminary X-ray diffraction studies of the metal-ion-mediated ternary complex of the HutP protein with L-histidine and its cognate RNA.

  2004cites this paper
• The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition.

  2004cites this paper
• Kinetic Studies of the Uracil Phosphoribosyltransferase Reaction Catalyzed by the Bacillus subtilis Pyrimidine Attenuation Regulatory Protein PyrR*

  2003cites this paper
• The Purine Repressor of Bacillus subtilis: a Novel Combination of Domains Adapted for Transcription Regulation

  2003cites this paper
• Betaine-homocysteine methyltransferase: zinc in a distorted barrel.

  2002cites this paper
• Control of transcription termination in bacteria by RNA-binding proteins that modulate RNA structures

  2002cites this paper
• Characterization of the Interaction of Bacillus subtilis PyrR with pyr mRNA by Site-Directed Mutagenesis of the Protein

  2002cites this paper
• Transcription attenuation.

  2002cites this paper
• RNA recognition by transcriptional antiterminators of the BglG/SacY family: mapping of SacY RNA binding site.

  2002cites this paper
• Purine, pyrimidine and pyridine nucleotide metabolism

  2002cites this paper
• Attenuation Of Transcription

  2002cites this paper
• The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase

  2002cites this paper
• Molecular recognition of pyr mRNA by the Bacillus subtilis attenuation regulatory protein PyrR.

  2001cites this paper
• The regulatory roles of PyrR and Crc in pyrimidine metabolism in Pseudomonas aeruginosa

  2001cites this paper
• Structural characteristics of protein binding sites for calcium and lanthanide ions

  2001cites this paper
• The PRT protein family.

  2001cites this paper
• The Pyrimidine Operon pyrRPB-carA fromLactococcus lactis

  2001cites this paper
• cis‐Acting regulatory sequences for antitermination in the transcript of the Bacillus subtilis hut operon and histidine‐dependent binding of HutP to the transcript containing the regulatory sequences

  2000cites this paper
• Characterization of novel proteins based on known protein structures.

  2000cites this paper
• Transcription termination control in bacteria.

  2000cites this paper
• Purification, crystallization and preliminary X-ray crystallographic analysis of ATP-phosphoribosyltransferase from Escherichia coli.

  2000cites this paper
• Transcription Attenuation: Once Viewed as a Novel Regulatory Strategy

  2000cites this paper
• Regulation of the Bacillus subtilis pyrimidine biosynthetic operon by transcriptional attenuation: control of gene expression by an mRNA-binding protein.

  1999cites this paper
• Forming and inhibiting PRT active sites.

  1999cites this paper
• Forming and inhibiting PRT active sites

  1999cites this paper
• RNA-protein complexes.

  1999cites this paper
• RNA Recognition by Transcriptional Antiterminators of the BglG/SacY Family: Functional and Structural Comparison of the CAT Domain from SacY and LicT

  1999cites this paper
• Structure of the trp RNA-binding attenuation protein, TRAP, bound to RNA

  1999cites this paper
• The three-dimensional structures of nicotinate mononucleotide:5,6- dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9 A resolution.

  1999cites this paper
• RNA recognition by transcriptional antiterminators of the BglG/SacY family: functional and structural comparison of the CAT domain from SacY and LicT.

  1999cites this paper
• CobB, a New Member of the SIR2 Family of Eucaryotic Regulatory Proteins, Is Required to Compensate for the Lack of Nicotinate Mononucleotide:5,6-Dimethylbenzimidazole Phosphoribosyltransferase Activity in cobT Mutants during Cobalamin Biosynthesis inSalmonella typhimurium LT2*

  1998cites this paper
• Glutamine PRPP amidotransferase: snapshots of an enzyme in action.

  1998cites this paper
• Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.

  1998cites this paper
• Loyola eCommons Loyola eCommons

  year unknowncites this paper