SOX2 suppresses osteoblast differentiation of MC3T3-E1 cells through activating the transcription of LGR4

No abstract is available for this paper.

• Publication year

  2022

• Venue

  In Vitro Cellular & Developmental Biology - Animal

• Publication date

  2022-12-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11626-022-00740-4PMID 36547788
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Emerging Roles for LGR4 in Organ Development, Energy Metabolism and Carcinogenesis

  2022cited by this paper
• Rspo1–LGR4 axis in BMSCs protects bone against radiation‐induced injury through the mTOR‐dependent autophagy pathway

  2021cited by this paper
• DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells

  2021cited by this paper
• RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

  2021cited by this paper
• Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β‐catenin pathway

  2021influential reference
• LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families

  2021cited by this paper
• The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens

  2021cited by this paper
• Type H blood vessels in bone modeling and remodeling

  2020cited by this paper
• LGRs in Skeletal Tissues: An Emerging Role for Wnt‐Associated Adult Stem Cell Markers in Bone

  2020cited by this paper
• Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway

  2019cited by this paper
• The effect of Activin‐A on periodontal ligament fibroblasts‐mediated osteoclast formation in healthy donors and in patients with fibrodysplasia ossificans progressiva

  2018cited by this paper
• Sox2 is required for tumor development and cancer cells proliferation in osteosarcoma

  2018cited by this paper
• Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis

  2018cited by this paper
• Bone morphogenetic protein-2 enhances the osteogenic differentiation capacity of mesenchymal stromal cells derived from human bone marrow and umbilical cord

  2017cited by this paper
• Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways

  2016cited by this paper
• LGR4 and Its Role in Intestinal Protection and Energy Metabolism

  2015cited by this paper
• Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2

  2015cited by this paper
• SIRT1 Directly Regulates SOX2 to Maintain Self‐Renewal and Multipotency in Bone Marrow‐Derived Mesenchymal Stem Cells

  2014cited by this paper
• SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage.

  2013cited by this paper
• Serum response factor regulates bone formation via IGF‐1 and Runx2 signals

  2012cited by this paper
• SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis

  2010cited by this paper
• Nitric oxide and bone

  2010cited by this paper
• The transcription factor Sox2 is required for osteoblast self-renewal

  2010cited by this paper
• Regulation of Stem Cell Pluripotency and Differentiation Involves a Mutual Regulatory Circuit of the Nanog, OCT4, and SOX2 Pluripotency Transcription Factors With Polycomb Repressive Complexes and Stem Cell microRNAs

  2009cited by this paper
• PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.

  2009cited by this paper
• Signaling and transcriptional regulation in osteoblast commitment and differentiation.

  2007influential reference
• Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation

  2005cited by this paper
• A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.

  2002cited by this paper
• Nitric oxide and bone

  2001cited by this paper

• Evaluation of the prognostic role of SOX2 as a tumor stem cell marker in odontogenic cysts and tumors: clinical, radiographic and immunohistochemical correlation

  2025cites this paper
• Spheroids as a 3D in vitro model to study bone and bone mineralization.

  2023cites this paper