Acetylation of Sirt2 by p300 attenuates its deacetylase activity.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2008-10-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbrc.2008.08.042PMID 18722353
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2006cited by this paper
• Zinc hydrolases: the mechanisms of zinc-dependent deacetylases.

  2005cited by this paper
• SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1*

  2005cited by this paper
• Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

  2004cited by this paper
• The Sir2 family of protein deacetylases.

  2004cited by this paper
• Mammalian SIRT1 represses forkhead transcription factors.

  2004cited by this paper
• Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases.

  2004cited by this paper
• Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300

  2004cited by this paper
• Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation.

  2003cited by this paper
• The Transcriptional Co-activators CREB-binding Protein (CBP) and p300 Play a Critical Role in Cardiac Hypertrophy That Is Dependent on Their Histone Acetyltransferase Activity*

  2003cited by this paper
• The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

  2003cited by this paper
• Biological role of p300 in cardiac myocytes

  2003cited by this paper
• Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.

  2002cited by this paper
• Acetylation control of the retinoblastoma tumour-suppressor protein

  2001cited by this paper
• Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

  2001cited by this paper
• Negative Control of p53 by Sir2 Promotes Cell Survival under Stress

  2001cited by this paper
• Negative control of p53 by Sir2alpha promotes cell survival under stress.

  2001cited by this paper
• Mutations truncating the EP300 acetylase in human cancers

  2000cited by this paper
• CBP/p300 in cell growth, transformation, and development.

  2000cited by this paper
• Acetylation: a regulatory modification to rival phosphorylation?

  2000cited by this paper
• Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2.

  1999cited by this paper
• Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.

  1997cited by this paper
• The transcriptional coactivators p300 and CBP are histone acetyltransferases.

  1996cited by this paper
• The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

  1996cited by this paper

• Dynamic global acetylation remodeling during the yeast heat shock response

  2025cites this paper
• Structural basis for sirtuin 2 activity and modulation: Current state and opportunities

  2025cites this paper
• Deacetylation of ANXA2 by SIRT2 desensitizes hepatocellular carcinoma cells to donafenib via promoting protective autophagy

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• Tubulin Acetylation: A Critical Regulator of Microtubule Function.

  2025cites this paper
• A High-Fat and High-Fructose Diet Exacerbates Liver Dysfunction by Regulating Sirtuins in a Murine Model

  2024cites this paper
• Serum metabolomics analysis combined with network pharmacology reveals possible mechanisms of postoperative cognitive dysfunction in the treatment of Mongolian medicine Eerdun Wurile basic formula.

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• HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape

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• S6K2 in Focus: Signaling Pathways, Post-Translational Modifications, and Computational Analysis

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• Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG

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• 2‐(Methyl(phenyl)amino)‐N‐(phenyloxyphenyl)acetamide structural motif representing a framework for selective SIRT2 inhibition

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• Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells

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• P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma

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  2023cites this paper
• Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations.

  2022cites this paper
• Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates

  2022cites this paper
• Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication

  2022cites this paper
• Post-translational Lysine Ac(et)ylation in Bacteria: A Biochemical, Structural, and Synthetic Biological Perspective

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• Chromatin Modifiers in Transcriptional Regulation: New Findings and Prospects

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• Post-translational lysine ac(et)ylation in health, ageing and disease

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• Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators

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• Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress

  2021cites this paper
• Experimental approaches toward histone acetyltransferase modulators as therapeutics

  2021cites this paper
• Oncometabolism Drives Autophagy Activation in Skeletal Muscle

  2020cites this paper
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  2020cites this paper
• SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma

  2020cites this paper
• Current role of mammalian sirtuins in DNA repair.

  2019cites this paper
• SIRT2: Controversy and multiple roles in disease and physiology.

  2019cites this paper
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  2018cites this paper
• Identifying the enzymes that regulate acetylation of sarco(endo)plasmic reticulum calcium ATPase 2a (SERCA2a)

  2018cites this paper
• Development of Activity-Based Chemical Probes for Human Sirtuins.

  2018cites this paper
• Genomics and proteomics approaches to identify resveratrol targets in cancer

  2017cites this paper
• Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development.

  2017cites this paper
• Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

  2017cites this paper
• Histone acetyltransferases: challenges in targeting bi-substrate enzymes

  2016cites this paper
• The growing landscape of tubulin acetylation: lysine 40 and many more.

  2016cites this paper
• Experimental Approaches Toward Histone Acetyltransferase Inhibitors as Therapeutics

  2016cites this paper
• Cardiac Autophagy and Its Regulation by Reversible Protein Acetylation

  2016cites this paper
• SIRT2 orchestrates the DNA damage response

  2016cites this paper
• Characterisation of Sirtuins in Parkinson's disease

  2016cites this paper
• Who watches the watchmen? Regulation of the expression and activity of sirtuins

  2016cites this paper
• Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases.

  2016cites this paper
• Targeting Dysregulated Epigenetic Enzymes for Prostate Cancer Treatment

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• Manipulation of the host protein acetylation network by human immunodeficiency virus type 1

  2015cites this paper
• Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation*

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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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• How Histone Deacetylases Control Myelination

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• Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates

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• Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity.

  2009cites this paper
• Sirtuins and p53.

  2009cites this paper