NHERF (Na+/H+ Exchanger Regulatory Factor) gene mutations in human breast cancer

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Oncogene

• Publication date

  2004-11-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1207962PMID 15467753
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Estrogen use and cancer risk: a review.

  2009cited by this paper
• NHERF‐1 uniquely transduces the cAMP signals that inhibit sodium–hydrogen exchange in mouse renal apical membranes

  2003influential reference
• Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse

  2003cited by this paper
• Allelotype of 28 human breast cancer cell lines and xenografts

  2003cited by this paper
• Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer.

  2003cited by this paper
• Syk, a Protein-tyrosine Kinase, Suppresses the Cell Motility and Nuclear Factor κB-mediated Secretion of Urokinase Type Plasminogen Activator by Inhibiting the Phosphatidylinositol 3′-Kinase Activity in Breast Cancer Cells*

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• Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation.

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• Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

  2002cited by this paper
• Hypoxia — a key regulatory factor in tumour growth

  2002cited by this paper
• NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas.

  2001cited by this paper
• Hypermethylation leads to silencing of the SYK gene in human breast cancer.

  2001cited by this paper
• NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3.

  2000influential reference
• Causes and consequences of tumour acidity and implications for treatment.

  2000cited by this paper
• The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

  2000influential reference
• Estrogen receptor regulation of the Na+/H+ exchange regulatory factor.

  1999cited by this paper
• Yes-Associated Protein 65 Localizes P62c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50

  1999cited by this paper
• 17q21-q25 aberrations in breast cancer: combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification

  1999cited by this paper
• Estrogen Receptor Regulation of the Na+/H+ Exchanger Regulatory Factor.

  1999cited by this paper
• The Genetic Basis of Human Cancer

  1999cited by this paper
• The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.

  1998cited by this paper
• The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

  1998cited by this paper
• Peptide binding consensus of the NHE‐RF‐PDZ1 domain matches the C‐terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)

  1998cited by this paper
• NHE-RF, a Regulatory Cofactor for Na+-H+Exchange, Is a Common Interactor for Merlin and ERM (MERM) Proteins*

  1998influential reference
• Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

  1997cited by this paper
• Multistep carcinogenesis of breast cancer and tumour heterogeneity

  1997cited by this paper
• Four regions of allelic imbalance on 17q12‐qter associated with high‐grade breast tumors

  1997cited by this paper
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• The Genetic Basis of Human Cancer

  1997cited by this paper
• A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors

  1997cited by this paper
• Detailed deletion analysis of sporadic breast tumors defines an interstitial region of allelic loss on l7q25

  1996cited by this paper
• Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers

  1995cited by this paper
• Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis.

  1995cited by this paper
• Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers.

  1994cited by this paper
• Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types

  1994cited by this paper
• A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

  1993cited by this paper
• Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

  1993cited by this paper

• Pathophysiological role of ion channels and transporters in HER2-positive breast cancer

  2022cites this paper
• New roles of the Na/H exchange regulatory factor 1 scaffolding protein: a mini review.

  2020cites this paper
• Cancer-Associated Fibroblasts: Epigenetic Regulation and Therapeutic Intervention in Breast Cancer

  2020cites this paper
• NHERF1 Loss Upregulates Enzymes of the Pentose Phosphate Pathway in Kidney Cortex

  2020cites this paper
• Alteration in the sensitivity to crizotinib by Na+/H+ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers

  2020cites this paper
• NHERF1 is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland.

  2019cites this paper
• Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.

  2019cites this paper
• Identifying genetic loci for metabolic disorders affecting the renal tract

  2019cites this paper
• Computational Model for Predicting the Relationship Between Micro-RNAs and Their Target Messenger RNAs in Breast and Colon Cancers

  2018cites this paper
• NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling.

  2017cites this paper
• The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2

  2017cites this paper
• Study on Effects of NHERF-1 on Proliferation and Migration of Human Umbilical Vein Endothelial Cells

  2017cites this paper
• Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation

  2017cites this paper
• Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance

  2017cites this paper
• A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression.

  2017cites this paper
• NHERF1 Enhances Cisplatin Sensitivity in Human Cervical Cancer Cells

  2017cites this paper
• 8 Podocalyxin in the Diagnosis and Treatment of Cancer *

  2017cites this paper
• NHERF1 Suppresses Lung Cancer Cell Migration by Regulation of Epithelial-Mesenchymal Transition.

  2017cites this paper
• A Novel NHERF1 Mutation in Human Breast Cancer Inactivates Inhibition by NHERF1 Protein in EGFR Signaling.

  2016cites this paper
• The cell surface mucin podocalyxin regulates collective breast tumor budding

  2016cites this paper
• The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer

  2016cites this paper
• THE ROLE OF NHERF1/EBP50 IN WNT SIGNALING IN THE EPITHELIUM

  2015influential citation
• A novel splicing mutation in the SLC9A3R1 gene in tumors from ovarian cancer patients.

  2015influential citation
• The potential predictive role of nuclear NHERF1 expression in advanced gastric cancer patients treated with epirubicin/oxaliplatin/capecitabine first line chemotherapy

  2015cites this paper
• SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells

  2015cites this paper
• A critical role of CXCR2 PDZ-mediated interactions in endothelial progenitor cell homing and angiogenesis.

  2015cites this paper
• Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling.

  2015cites this paper
• The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer

  2014cites this paper
• PDGF receptor signaling networks in normal and cancer cells.

  2014cites this paper
• Exploring the Role of EBP50 in Vascular Inflammation

  2013cites this paper
• Breast cancer‐derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet‐derived growth factor receptor signaling

  2013influential citation
• EBP50 phosphorylation by Cdc2/Cyclin B kinase affects actin cytoskeleton reorganization and regulates functions of human breast cancer cell line MDA-MB-231

  2013cites this paper
• Podocalyxin in the Diagnosis and Treatment of Cancer

  2012cites this paper
• NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains

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• MAP17, a ROS-dependent oncogene

  2012cites this paper
• Ezrin-anchored Protein Kinase A Coordinates Phosphorylation-dependent Disassembly of a NHERF1 Ternary Complex to Regulate Hormone-sensitive Phosphate Transport*

  2012cites this paper
• NHERF1/EBP50 controls lactation by establishing basal membrane polarity complexes with prolactin receptor

  2012cites this paper
• A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ‐domains

  2012cites this paper
• Cell Cycle Dependent Association of EBP50 with Protein Phosphatase 2A in Endothelial Cells

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• Novel bioactivity of NHERF1 in corneal neovascularization

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• Prognostic value of acquired uniparental disomy (aUPD) in primary breast cancer

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• Na( (cid:1) )/H( (cid:1) ) Exchanger Regulatory Factor 1 (NHERF1) Is Required for the Estradiol-Dependent Increase of Phosphatase and Tensin Homolog (PTEN) Protein Expression

  2011cites this paper
• Regulation of G Protein-Coupled Receptor Function by Na+/H+ Exchange Regulatory Factors

  2011influential citation
• PDZ domains: the building blocks regulating tumorigenesis.

  2011cites this paper
• Immunohistochemical analysis of ezrin-radixin-moesin-binding phosphoprotein 50 in prostatic adenocarcinoma

  2011cites this paper
• Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) is required for the estradiol-dependent increase of phosphatase and tensin homolog (PTEN) protein expression.

  2011cites this paper
• Loss of Tumor Suppressor Merlin in Advanced Breast Cancer Is due to Post-translational Regulation*

  2011cites this paper
• Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance

  2011cites this paper
• Evidence for alteration of calpain/calpastatin system in PBMC of cystic fibrosis patients.

  2011cites this paper
• Case of Breast Cancer in a Neurofibromatosis 2 Patient

  2011influential citation
• Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour

  2011cites this paper
• Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance

  2011cites this paper
• NHERF1/EBP50 in Breast Cancer: Clinical Perspectives

  2010cites this paper
• Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation.

  2010cites this paper
• PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.

  2010cites this paper
• Dysfunctional AMPA Receptor Trafficking in Traumatic Brain Injury

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• NHERF1 – New Modifier of Colorectal Cancer Progression

  2010cites this paper
• Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

  2010cites this paper
• Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity

  2010cites this paper
• EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity

  2010influential citation
• brane in Glioblastoma Contributes to PTEN Inactivation

  2010cites this paper
• Biological role of NHERF1 protein expression in breast cancer

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• MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells

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• Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

  2009cites this paper
• Roles of NHERF1/EBP50 in cancer.

  2008cites this paper
• NHERF1: molecular brake on the PI3K pathway in breast cancer

  2008cites this paper
• Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.

  2008cites this paper
• Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells

  2008cites this paper
• NHERF1/EBP50 Head-to-Tail Intramolecular Interaction Masks Association with PDZ Domain Ligands

  2007cites this paper
• The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.

  2007influential citation
• NHERFs, NEP, MAGUKs, and more: Interactions that regulate PTEN

  2007cites this paper
• Cortical stabilization of β-catenin contributes to NHERF1/EBP50 tumor suppressor function

  2007cites this paper
• The Role of Tumour Suppressor Tyrosine Kinase SYK in Glioblastoma and Breast Cancer

  2007cites this paper
• Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin.

  2007cites this paper
• Expression and clinicopathological significance of oestrogen‐responsive ezrin–radixin–moesin‐binding phosphoprotein 50 in breast cancer

  2007cites this paper
• Protein Kinase C Phosphorylation Disrupts Na+/H+ Exchanger Regulatory Factor 1 Autoinhibition and Promotes Cystic Fibrosis Transmembrane Conductance Regulator Macromolecular Assembly*

  2007cites this paper
• Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)

  2006cites this paper
• Targeting PDZ domain proteins for treating NMDA receptor-mediated excitotoxicity.

  2006cites this paper
• Na+/H+ Exchanger Regulatory Factor‐1 Is a Hematopoietic Ligand for a Subset of the CD34 Family of Stem Cell Surface Proteins

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• The Syk tyrosine kinase: a new negative regulator in tumor growth and progression.

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• Ezrin Controls the Macromolecular Complexes Formed between an Adapter Protein Na+/H+ Exchanger Regulatory Factor and the Cystic Fibrosis Transmembrane Conductance Regulator*

  2005cites this paper
• The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells

  2005cites this paper